Clinical MR Spectroscopy: Techniques and Applications

by Peter B. Barker , Alberto Bizzi , Nicola De Stefano , Rao Gullapalli , Doris D. M. Lin

• ISBN13: 9780521868983
• ISBN10: 052186898X
• Edition: 1st
• Format: Hardcover
• Copyright: 2009-12-14
• Publisher: Cambridge University Press

Summary

In vivo magnetic resonance spectrosopy (MRS) is increasingly being used in the clinical setting, particularly for neurological disorders. Clinical MR Spectroscopy - Techniques and Applications explains both the underlying physical principles of MRS and provides a perceptive review of clinical MRS applications. Topics covered include an introduction to MRS physics, information content of spectra from different organ systems, spectral analysis methods, recommended protocols and localization techniques, and normal age- and region-related spectral variations in the brain. Clinical applications in the brain are discussed for brain tumors, hypoxic and ischemic injury, infectious, inflammatory and demyelinating diseases, epilepsy, neurodegenerative disorders, trauma and metabolic diseases. Outside of the brain, techniques and applications are discussed for MRS in the musculosketal system, breast and prostate. Written by leading MRS experts, this is an invaluable guide for anyone interested in in vivo MRS, including radiologists, neurologists, neurosurgeons, oncologists and medical researchers.

Author Biography

Peter B. Barker is Professor of Radiology and Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. Nicola De Stefano is Associate Professor of Neurology, University of Siena, Siena, Italy. Alberto Bizzi is a Neuroradiologist at the Fondazione IRCCS Istituto Neurologico, Carlo Besta in Milan, Italy. Rao Gullapalli is Associate Professor of Radiology and Director, Core for Translational Research in Imaging at Maryland (C-TRIM), University of Maryland, Baltimore, MD, USA. Doris D. M. Lin is Assistant Professor of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Table of Contents

Preface	p. vii
Acknowledgments	p. viii
Abbreviations	p. ix
Introduction to MR spectroscopy in vivo	p. 1
Pulse sequences and protocol design	p. 19
Spectral analysis methods, quantitation, and common artifacts	p. 34
Normal regional variations: brain development and aging	p. 51
MRS in brain tumors	p. 61
MRS in stroke and hypoxic-ischemic encephalopathy	p. 91
MRS in infectious, inflammatory, and demyelinating lesions	p. 110
MRS in epilepsy	p. 131
MRS in neurodegenerative disease	p. 144
MRS in traumatic brain injury	p. 161
MRS in cerebral metabolic disorders	p. 180
MRS in prostate cancer	p. 212
MRS in breast cancer	p. 229
MRS in musculoskeletal disease	p. 243
Index	p. 256
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