Clinical Pharmacokinetics and Pharmacodynamics Concepts and Applications

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  • Edition: 4th
  • Format: Hardcover
  • Copyright: 2010-02-05
  • Publisher: LWW

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Formerly "Clinical Pharmacokinetics: Concepts and Clinical Applications, " this fully updated Fourth Edition has been retitled "Pharmacokinetics and Pharmacodynamics: Concepts and Clinical Applications" to reflect the increasing body of knowledge linking the two concepts that explain the relationship between drug administration and drug response. This revised edition also reflects the explosion in our understanding at the molecular and mechanistic levels of all the processes controlling the pharmacokinetics of drugs. The text is authored by two leading international experts on the clinical aspects of pharmacokinetics/pharmacodynamics and is widely considered one of the authoritative texts on the subject.

Table of Contents

Prefacep. ix
Nonproprietary and Brand Names of Drugs in Text and Illustrationsp. xiii
Definition of Symbolsp. xix
Basic Considerations
Therapeutic Relevancep. 3
Fundamental Concepts and Terminologyp. 17
Exposure and Response after a Single Dose
Kinetics Following an Intravenous Bolus Dosep. 49
Membranes and Distributionp. 73
Eliminationp. 111
Kinetics Following an Extravascular Dosep. 159
Absorptionp. 183
Response Following a Single Dosep. 217
Therapeutic Regimens
Therapeutic Windowp. 245
Constant-Rate Inputp. 259
Multiple-Dose Regimensp. 293
Variabilityp. 333
Geneticsp. 357
Age, Weight, and Genderp. 373
Diseasep. 403
Nonlinearitiesp. 445
Drug Interactionsp. 483
Initiating and Managing Therapyp. 527
Supplemental Topics
Distribution Kineticsp. 561
Metabolites and Drug Responsep. 603
Protein Drugsp. 633
Prediction and Refinement of Human Kinetics from In Vitro, Preclinical, and Early Clinical Datap. 663
Assessment of AUCp. 687
Ionization and the pH Partition Hypothesisp. 691
Distribution of Drugs Extensively Bound to Plasma Proteinsp. 695
Plasma-to-Blood Concentration Ratiop. 703
Well-stirred Model of Hepatic Clearancep. 705
Absorption Kineticsp. 709
Wagner-Nelson Methodp. 713
Mean Residence Timep. 717
Amount of Drug in Body on Accumulation to Plateaup. 723
Answers to Study Problemsp. 727
Indexp. 819
Table of Contents provided by Ingram. All Rights Reserved.

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