Preface | p. ix |
Nonproprietary and Brand Names of Drugs in Text and Illustrations | p. xiii |
Definition of Symbols | p. xix |
Basic Considerations | |
Therapeutic Relevance | p. 3 |
Fundamental Concepts and Terminology | p. 17 |
Exposure and Response after a Single Dose | |
Kinetics Following an Intravenous Bolus Dose | p. 49 |
Membranes and Distribution | p. 73 |
Elimination | p. 111 |
Kinetics Following an Extravascular Dose | p. 159 |
Absorption | p. 183 |
Response Following a Single Dose | p. 217 |
Therapeutic Regimens | |
Therapeutic Window | p. 245 |
Constant-Rate Input | p. 259 |
Multiple-Dose Regimens | p. 293 |
Individualization | |
Variability | p. 333 |
Genetics | p. 357 |
Age, Weight, and Gender | p. 373 |
Disease | p. 403 |
Nonlinearities | p. 445 |
Drug Interactions | p. 483 |
Initiating and Managing Therapy | p. 527 |
Supplemental Topics | |
Distribution Kinetics | p. 561 |
Metabolites and Drug Response | p. 603 |
Protein Drugs | p. 633 |
Prediction and Refinement of Human Kinetics from In Vitro, Preclinical, and Early Clinical Data | p. 663 |
Appendices | |
Assessment of AUC | p. 687 |
Ionization and the pH Partition Hypothesis | p. 691 |
Distribution of Drugs Extensively Bound to Plasma Proteins | p. 695 |
Plasma-to-Blood Concentration Ratio | p. 703 |
Well-stirred Model of Hepatic Clearance | p. 705 |
Absorption Kinetics | p. 709 |
Wagner-Nelson Method | p. 713 |
Mean Residence Time | p. 717 |
Amount of Drug in Body on Accumulation to Plateau | p. 723 |
Answers to Study Problems | p. 727 |
Index | p. 819 |
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