Combinatorial Chemistry : A Practical Approach

by Editor: Willi Bannwarth (Universität Freiburg, Germany); Editor: Eduard Felder (Novartis Pharma AG, Basel, Switzerland); Series Editor: Raimund Mannhold (Univ. of Düsseldorf, Germany); Series Editor: Hugo Kubinyi (BASF AG, Ludwigshafen, Germany);

• ISBN13: 9783527301867
• ISBN10: 3527301860
• Format: Hardcover
• Copyright: 2000-09-01
• Publisher: Wiley-VCH

Summary

As we enter the new millennium, combinatorial chemistry is providing significant impetus to new innovations in synthetic chemistry. Combinatorial chemistry has rapidly become the rising star among research methods, allowing scientists to efficiently test the feasibility of a multitude of new compounds.The pursuit of new drugs is but one challenging field in which these combinatorial methods are particularly advantageous, helping researchers meet the modern-day demands of a highly competitive environment.This book emphasises that modern combinatorial synthesis is possible not only in the solid phase, but also in solutions. Moreover, it discusses computer-assisted methods as well as the apparatus and instrumentation required for the combinatorial method. Successful and experienced researchers in the leading pharmaceutical companies and most renowned research institutes offer a solid insight and perspective into this diverse field.A 'must' for every scientist in the area of pharmaceutical research.

Table of Contents

General Introduction (W. Bannwarth).

Combinatorial Chemistry in Solution (W. Bannwarth).

Solid-Phase Chemistry (W. Bannwarth).

Polymer-Supported Reagents: Preparation and Use in Parallel Organic Synthesis (B. Hinzen).

Encoding Strategies for Combinatorial Libraries (B. Hinzen).

Automation and Devices for Combinatorial Chemistry and Parallel Organic Synthesis (C. Zechel).

Computer-Assisted Library Design (A. Dominik).

Organic Reactions on Solid Phase - A Survey of the Literature from 1970 to 1998 (A. Scannell-Lansky & C. Zechel).

References.

Index.