9780470903230

Control of Biological and Drug-Delivery Systems for Chemical, Biomedical, and Pharmaceutical Engineering

by
  • ISBN13:

    9780470903230

  • ISBN10:

    0470903236

  • Format: Hardcover
  • Copyright: 2013-01-04
  • Publisher: Wiley

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Supplemental Materials

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Summary

This book combines knowledge of process dynamics and basic control theory to analyze a range of bioprocesses and drug-release devices. The book addresses issues and solves problems that dominate both fields (i.e., biological sciences and release devices.) Many of the textbooks written on this topic usually focus on specific topics (e.g., systems biology, control of fermentation processes), as a result, undergraduate chemical engineering students are not exposed to a range of diversified problems in biological sciences. This book builds on the new focus of providing problems in the biological area. In addition, unified theories and step-by-step problem solving procedures are provided. A unique feature of the book is the application of control theory to analyze controlled-release devices. An expected outcome of the proposed perspective is an enrichment of fundamental concepts and the development of an application-oriented environment. For example pharmaceutical companies, specializing in the production of therapeutics using biological processes, are the first beneficiaries. A qualified labor force, with competencies in process analysis, design and control will assure that the target quantity and quality of the end-products are met and in line with federal and state regulations.

Author Biography

LAURENT SIMON, PhD, is Associate Professor of Chemical Engineering and Associate Director of the Pharmaceutical Engineering Program at New Jersey Institute of Technology. His research and teaching interests focus on modeling, analysis, and control of drug delivery systems. Dr. Simon is the author of Laboratory Online, a series of educational and interactive modules that help engineers build a strong understanding of drug delivery technologies and their underlying engineering principles. During his time at NJIT, Dr. Simon has received the Excellence in Teaching Award, Master Teacher Designation, and Newark College of Engineering Saul K. Fenster Innovation in Engineering Education Award.

Table of Contents

Introduction
The Role of Process Dynamics and Control in Branches of Biology
The Role of Process Dynamics and Control in Drug-Delivery Systems
Instrumentation
Summary
Mathematical Models
Background
Dynamics of Bioreactors
One- and Two-Compartment Models
Enzyme Kinetics
Summary
Linearization and Deviation Variables
Computer Simulations
Linearization of Systems
Glycolytic Oscillation
Hodgkin-Huxley Model
Summary
Stability Considerations
Definition of Stability
Steady-State Conditions and Equilibrium Points
Phase-Plane Diagrams
Population Kinetics
Dynamics of Bioreactors
Glycolytic Oscillation
Hodgkin-Huxley Model
Summary
Laplace Transforms of Linear Systems
Definitions of Laplace Transforms
Properties of Laplace Transforms
Laplace Transforms of Functions, Derivatives and Integrals
Laplace Transforms of Linear Ordinary and Partial Differential Equations
Continuous Fermentation
Two-Compartment Models
Gene Regulation
Summary
Inverse Laplace Transforms
Heaviside Expansions
Residue Theorem
Continuous Fermentation
Degradation of Plasmid DNA
Constant-Rate Intravenous Infusion
Transdermal Drug-Delivery Systems
Summary
Transfer Functions
Input-Output Models
Derivation of Transfer Functions
One- and Two-Compartment Models: Michaelis-Menten Kinetics
Controlled-Release Systems
Summary
Dynamic Behaviors of Typical Plants
First-, Second- and Higher-Order Systems
Reduced-Order Models
Transcendental Transfer Functions
Time Responses of Systems with Rational Transfer Functions
Time Responses of Systems with Transcendental Transfer Functions
Bone Regeneration
Nitric Oxide Transport to Pulmonary Arterioles
Transdermal Drug Delivery
Summary
Closed-Loop Responses with P, PI and PID Controllers
Block Diagram of Closed-Loop Systems
Proportional Control
Proportional-Integral Control
Proportional-Integral-Derivative Control
Total Sugar Concentration in a Glutamic Acid Production
Temperature Control of Fermentations
Dissolved Oxygen Concentration
Summary
Frequency Response Analysis
Frequency Response for Linear Systems
Bode Diagrams
Nyquist Plots
Transdermal Drug Delivery
Compartmental Models
Summary
Stability Analysis of Feedback Systems
Routh-Hurwitz Stability Criterion
Root Locus Analysis
Bode Stability Criterion
Nyquist Stability Criterion
Cheyne-Stokes Respiration
Regulation of Biological Pathways
Pupillary Light Reflex
Summary
Design of Feedback Controllers
Tuning Methods for Feedback Controllers
Regulation of Glycemia
Dissolved Oxygen Concentration
Control of Biomass in a Chemostat
Controlled Infusion of Vasoactive Drugs
Bone Regeneration
Fed-Batch Biochemical Processes
Summary
Feedback Control of Dead-Time Systems
Smith Predictor-Based Methods
Control of Biomass
Zymomonas Mobilis Fermentation for Ethanol Production
Fed-batch Cultivation of Acinetobacter Calcoaceticus RAG-1
Regulation of Glycemia
Summary
Cascade and Feedforward Control Strategies
Cascade Control
Feedforward Control
Insulin Infusion
A Gaze Control System
Control of pH
Summary
Effective Time Constant
Linear Second-Order Ordinary Differential Equations
Sturm-Liouville Eigenvalue Problems
Relaxation Time Constant
Implementation in Mathematica?
Controlled-Release Devices
Summary
Optimal Control and Design
Orthogonal Collocation Techniques
Dynamic Programming
Optimal Control of Drug-Delivery Rates
Optimal Design of Controlled-Release Devices
Implementations in Mathematica?
Summary
Table of Contents provided by Publisher. All Rights Reserved.

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