Cutaneous Neuroimmunomodulation : The Proopiomelanocortin System

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  • Edition: 1st
  • Format: Hardcover
  • Copyright: 1999-12-01
  • Publisher: New York Academy of Sciences

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Table of Contents

The Proopiomelanocortin System in Cutaneous Neuroimmunomodulation: An Introductory Overview xi
Thomas A. Luger
Ralf Paus
Andrzej Slominski
James Lipton
Part I. Extracutaneous Proopiomelanocortin Biology
The Proopiomelanocortin System
Mac E. Hadley
Carrie Haskell-Luevano
POMC--Derived Peptides and Their Biological Action
Samuel Solomon
The Pituitary-Skin Connection in Amphibians: Reciprocal Regulation of Melanotrope Cells and Dermal Melanocytes
H. Vaudry
N. Chartrel
L. Desrues L. Galas
S. Kikuyama
A. Mor
P. Nicolas
M.C. Tonon
The Subtilisin/Kexin Family of Precursor Convertases: Emphasis on PCI, PC2/ 7B2, POMC, and the Novel Enzyme SKI-1
Nabil G. Seidah
Suzanne Benjannet
Josee Hamelin
Aida M. Mamarbachi
Ajoy Basak
Jadwiga Marcinkiewicz
Majambu Mbikay
Michel Chretien
Mieczyslaw Marcinkiewicz
The Role of Melanocortins in Adipocyte Function
Bruce A. Boston
An Immunocytochemical Approach to the Study of β-Endorphin Production in Human Keratinocytes using Confocal Microscopy
Susana B. Zanello
David M. Jackson
Michael F. Holick
Part II. The Melanocortin Receptors
UV Light and MSH Receptors
Ashok K. Chakraborty
Yoko Funasaka
Andrzej Slominski
Jean Bolognia
Stefano Sodi
Masamitsu Ichihashi
John M. Pawelek
The Melanocortin-1 Receptor and Human Pigmentation
Zalfa Abdel-Malek
Itaru Suzuki
Akihiro Tada
Sungbin Im
Can Akcali
Genetic Studies of the Human Melanocortin-1 Receptor
Jonathan L. Rees
Mark Birch-Machin
Niamh Flanagan
Eugene Healy, Sion Phillips
Carole Todd
Molecular Pharmacology of Agouti Protein in Vitro and in Vivo
Gregory S. Barsh
Michael M. Ollmann
Brent D. Wilson
Kimberly A. Miller
Teresa M. Gunn
Synthetic Melanocortin Receptor Agonists and Antagonists
Michael R. Lerner
Proopiomelanocortin and the Immune-Neuroendocrine Connection
J. Edwin Blalock
Part III. Proopiomelanocortin and the Skin Immune System: Modulation of the Immune Response
Mechanisms of Antinflammatory Action of α-MSH Peptides: In Vivo and in Vitro Evidence
J.M. Lipton
H. Zhao
T. Ichiyama
G.S. Barsh
A. Catania
α-MSH in Systemic Inflammation: Central and Peripheral Actions
Anna Catania
Rene Delgado
Lorena Airaghi
MariaGrazia Cutul
Letizia Garofalo
Andrea Carlin
Maria Teresa Demitri
James M. Lipton
Human Peripheral Blood-Derived Dendritic Cells Express Functional Melanocortin Receptor MC-1R
E. Becher
K. Mahnke
T. Brzoska
D.-H. Kalden, S. Grabbe
T.A. Luger
Neural Influences on Induction of Contact Hypersensitivity
J. Wayne Streilein
Pascale Alard
Hironori Nizeki
Role of Epidermal Cell-Derived α-Melanocyte Stimulating Hormone in Ultraviolet Light Mediated Local Immunosuppression
T.A. Luger
T. Schwarz
H. Kalden
T. Scholzen
A. Schwarz
T. Brzoska
Part IV. Modulation of Skin Physiology by Proopiomelanocortin Products
α-MSH and the Regulation of Melanocyte Function
Anthony J. Thody
Molecular Basis of the α-MSH/IL-I Antagonism
T. Brzoska
D.-H. Kalden
T. Scholzen
T.A. Luger
Expression of Functional Melanocortin Receptors and Proopiomelanocortin Peptides Human Dermal Microvascular Endothelial Cells
Thomas E. Scholzen
Thomas Brzoska
Dirk-Henner Kalden
Mechthild Hartmeyer
Michaela Fastrich
Thomas A. Luger
Cheryl A. Armstrong
John C. Ansel
Mechanisms of the Antiinflammatory Effects of α-MSH: Role of Transcription Factor NF-κB and Adhesion Molecule Expression
D.-H. Kalden
T. Scholzen
T. Brzoska
T.A. Luger
POMC and Fibroblast Biology
Torello Lotti
Patrizia Teofoli
Beatrice Bianchi
Alain Mauviel
The Role of Proopiomelanocortin-Derived Peptides in Skin Fibroblast and Mast Cell Functions
Patrizia Teofoli
Alessandra Frezzolini
Pietro Puddu
Ornella De Pita
Alain Mauviel
Torello Lotti
Alpha-Melanocyte-Stimulating Hormone Modulates Activation of NF-κB and AP-1 and Secretion of Interleukin-8 in Human Dermal Fibroblasts
Markus Bohm
Ursula Schulte
Henner Kalden
T.A. Luger
Part V. Corticotropin-Releasing Hormone-Proopiomelanocortin Interactions
Cutaneous Expression of CRH and CRH-R: Is There a ``Skin Stress Response System?''
Andrzej T. Slominski
Vladimir Botchkarev
Mashkoor Choudhry
Nadeem Fazal
Klaus Fechner
Jens Furkert
Eberhart Krause
Birgit Roloff
Mohammad Sayeed
Edward Wei
Blazej Zbytek
Josef Zipper
Jacobo Wortsman
Ralf Paus
Corticotropin Releasing Factor Receptors and Their Ligand Family
Marilyn H. Perrin
Mylie W. Vale
Part VI. Proopiomelanocortin-Peptides-Clinical Relevance
α-MSH Can Control the Essential Cofactor 6-Tetrahydrobiopterin in Melanogenesis
Karin U. Schallreuter
Jeremy Moore
Desmond J. Tobin
Nicholas J.P. Gibbons
Harriet S. Marshall
Tracey Jenner
Wayne D. Beazley
John M. Wood
Melanocortins and the Treatment of Nervous System Disease: Potential Relevance to the Skin
Willem Hendrik Gispen
Roger A.H. Adan
The Skin POMC System (SPS): Leads and Lessons from the Hair Follicle
Ralf Paus
Vladimir A. Botchkarev
Natalia V. Botchkareva
Lars Mecklenburg
Thomas Luger
Andrzej Slominski
Part VII. Poster Papers
Expression of MCI-and MC5-Receptors on the Human Mast Cell Line HMC-1
M. Artuc
A. Grutzkau
Th. Luger
B.M. Henz
Characterization of μ-Opiate Receptor in Human Epidermis and Keratinocytes
M. Bigliardi-Qi
P.L. Bigliardi
S. Buchner
T. Rufli
Characterization of a Polyclonal Antibody Raised Against the Human Melanocortin-1 Receptor
Markus Bohm
Thomas Brzoska
Ursula Schulte
Meinhard Schiller
Ulrich Kubitscheck
Thomas A. Luger
Effects of Ethanol Consumption on β-Endorphin Levels and Natural Killer Cell Activity in Rats
Nadka Boyadjieva
Gary Meadows
Dipak Sarkar
Murine Dendritic Cells Express Functional Delta-Type Opioid Receptors
Clemens Esche
Valeria P. Makarenkova
Natalia V. Kost
Michael T. Lotze
Andrey A. Zozulya
Michael R. Shurin
Expression of Corticotropin Releasing Hormone in Malignant Melanoma
Yoko Funasaka
Hirofumi Sato
Masamitsu Ichihashi
Depression Modulates Pruritus Perception: A Study of Pruritus in Psoriasis, Atopic Dermatitis and Chronic Idiopathic Urticaria
Madhulika A. Gupta
Aditya K. Gupta
β-MSH Immunomodulation Acts via Rel/NF-κB in Cutaneous and Ocular Melanocytes and in Melanoma Cells
J.W. Haycock
M. Wagner
R. Morandini
G. Ghanem
I.G. Rennie
S. MacNeil
Microinjection of Alpha-MSH Followed by UV-Irradiation Blocks HSP 72 in Human Keratinocytes
Bjorn Held
Susanne Amato
Ernst G. Jung
Christiane Bayerl
β-Endorphin Binding and Regulation of Cytokine Expression in Langerhans Cells
Junichi Hosoi
Hiroaki Ozawa
Richard D. Granstein
α-MSH Reduces Vasculitis in the Local Shwartzman Reaction
Cord Sunderkotter
H. Kalden
T. Brzoska
Clemens Sorg
Thomas A. Luger
Implications of the Phenotype of POMC Deficiency for the Role of POMC-Derived Peptides in Skin Physiology
Heiko Krude
Dirk Schnabel
Werner Luck
Annette Gruters
Serotonin in Human Allergic Contact Dermatitis
L. Lundeberg
E. Sundstrom
K. Nordlind
A. Verhofstad
O. Johansson
Differential Temporal and Spatial Expression of POMC mRNA and of the Production of POMC Peptides During the Murine Hair Cycle
J. E. Mazurkiewicz
D. Corliss
A. Slominski
Effective Treatment of Pruritus with Naltrexone, an Orally Active Opiate Antagonist
D. Metze
S. Reimann
T.A. Luger
Developmentally Regulated Expression of α-MSH and MC-1 Receptor in C57BL/6 Mouse Skin Suggests Functions Beyond Pigmentation
V.A. Botchkarev
N.V. Botchkareva
A. Slominski
B. Roloff
T. Luger
R. Paus
Plasma β-Endorphin Concentrations During Natural and Artificially Induced Winter Hair Growth in Mink (Mustela vison)
J. Rose
K. Wood
J. Billingsley
J. Olbertz
A. Lovering
J. Carr
Expression of Proopiomelanocortin Peptides and Prohormone Convertases by Human Dermal Microvascular Endothelial Cells
Thomas E. Scholzen
Thomas Brzoska
Dirk-Henner Kalden
Mechthild Hartmeyer
Thomas A. Luger
Cheryl A. Armstrong
John C. Ansel
ACTH Production in C57BL/6 Mouse Skin
Andrzej Slominski
Natalia V. Botchkareva
Vladimir A. Botchkarev
Ashok Chakraborty
Thomas Luger
Murat Uenalan
Ralf Paus
Coexpression of Nitric Oxide Synthase and POMC Peptides in the Dystrophic C57BL/6J Mouse
Margaret E. Smith
Ravinder K. Phul
Ligand Binding Profile and Effects of Melanin-Concentrating Hormone on Fish and Mammalian Skin Cells
T. Suply
B. Cardinaud
S. Kanamori
C. Dal Farra
S. Ricois
J.L. Nahon
Occurrence of Four MSHs in Dogfish POMC and Their Immunomodulating Effects
Akiyoshi Takahashi
Yutaka Amemiya
Masahiro Sakai
Akikazu Yasuda
Nobuo Suzuki
Yuichi Sasayama
Hiroshi Kawauchi
Specific Binding Sites for β-Endorphin on Keratinocytes
K. Egeling
H. Muller
B. Karschunke
M. Tschischka
V. Spennemann
B. Hain
H. Teschemacher
Skin POMC Peptides: Their Binding Affinities and Activation of the Human MCI Receptor
Marina Tsatmalia
Kazumasa Wakamatsu
Alison J. Graham
Anthony J. Thody
The Expression of α-MSH by Melanocytes Is Reduced in Vitiligo
Alison Graham
Wiete Westerhof
Anthony J. Thody
α-MSH Inhibits Lipopolysaccharide Induced Nitric Oxide Production in B16 Mouse Melanoma Cells
Marina Tsatmali
Philip Manning
Calum J. McNeil
Anthony J. Thody
Index of Contributors 477

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