Destruction of Hazardous Chemicals in the Laboratory

by Lunn, George; Sansone, Eric B.

• ISBN13: 9781118146606
• ISBN10: 1118146603
• Edition: 3rd
• Format: eBook
• Copyright: 2012-07-09
• Publisher: Wiley

Summary

The book describes practical procedures for the destruction of hazardous chemicals and biological agents in the laboratory in which they are used. The book is a continuation and expansion of “Destruction of Hazardous Chemicals in the Laboratory.” It follows the same general approach as the first and second editions but includes a number of new chapters including one on using advanced oxidation techniques as a general means of degrading chemicals. All the monographs from the second edition are incorporated in this volume and are revised and extended as necessary.  A number of new monographs describing procedures for the destruction of hazardous chemicals have also been added.

The destruction of many pharmaceuticals is also described in this book. This subject has become of increasing importance with recent reports of the detection of pharmaceuticals in the water supply. Finally a new addition is the chapter “General Methods for the Destruction of Hazardous Chemicals in the Laboratory.” This chapter describes recent advanced oxidation methods that should be generally applicable to all organic compounds.  The methods use commonly available laboratory equipment and reagents.

Author Biography

George Lunn, PhD, has been working as a review chemist for the FDA's Office of New Drug Quality Assessment since 1996. Previously, he was a senior research scientist in the Environmental Control and Research Program at the NCI-Frederick Cancer Research and Development Center. He has written nine books and over sixty papers and review articles.

Eric B. Sansone, PhD, was the director of the Environmental Control and Research Program at the NCI-Frederick Cancer Research and Development Center until his retirement. He has also worked as a consultant in industrial hygiene and air pollution control for a widely diversified group of industries, law firms, universities, and governmental agencies. He has published many articles on the assessment of risk in cancer research.

Table of Contents

PREFACE xi

ACKNOWLEDGMENTS xiii

INTRODUCTION 1

SPECIFIC METHODS FOR THE DESTRUCTION OF HAZARDOUS CHEMICALS IN THE LABORATORY 17

Acetonitrile 19

Acid Halides and Anhydrides 23

Aflatoxins 29

Alkali and Alkaline Earth Metals 37

Alkali Metal Alkoxides 41

Anatoxin-A 43

Aromatic Amines 47

Arsenic 57

Azides 61

Azo and Azoxy Compounds and Tetrazenes 69

Boron Trifluoride and Inorganic Fluorides 77

Botulinum Toxins 81

Brevetoxins 85

Butyllithium 89

Calcium Carbide 93

Carbamic Acid Esters 95

Carbofuran 99

Chloromethylsilanes and Silicon Tetrachloride 101

N-Chlorosuccinimide and Chloramine-T 103

Chlorosulfonic Acid 105

Chromium(VI) 107

Citrinin 113

Complex Metal Hydrides 121

Cyanides and Cyanogen Bromide 129

Cylindrospermopsin 137

Diisopropyl Fluorophosphate 141

Dimethyl Sulfate and Related Compounds 151

Dyes and Biological Stains 163

Ethidium Bromide 201

Haloethers 211

Halogenated Compounds 217

Halogens 229

Heavy Metals 233

Hexamethylphosphoramide 241

Hydrazines 245

Hypochlorites 257

Mercury 261

2-Methylaziridine 267

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 271

Microcystins 277

4-Nitrobiphenyl 283

3-Nitrofluoranthene and 3-Aminofluoranthene 287

Nitrogen Tetroxide 291

N-Nitroso Compounds: Nitrosamides 293

N-Nitroso Compounds: Nitrosamines 307

Ochratoxin A 319

Organic Nitriles 327

Osmium Tetroxide 331

Palytoxin 335

Patulin 339

Peracids 347

Perchlorates 349

Peroxides and Hydroperoxides 355

Phenol 359

Phosgene 363

Phosphorus and Phosphorus Pentoxide 367

Picric Acid 371

Polycyclic Aromatic Hydrocarbons 375

Polycyclic Heterocyclic Hydrocarbons 387

Potassium Permanganate 405

b-Propiolactone 407

Protease Inhibitors 411

Ricin 417

Saxitoxin 421

Selenium Compounds 425

Sodium Amide 427

Sterigmatocystin 429

Sulfonyl Fluoride Enzyme Inhibitors 437

Sulfur-Containing Compounds 443

T-2 Toxin 449

Tetrodotoxin 455

Triacetone Triperoxide 459

Uranyl Compounds 463

METHODS FOR THE DESTRUCTION OF PHARMACEUTICALS IN THE LABORATORY 467

Pharmaceuticals: General Considerations 469

A: Potassium Permanganate 549

B: Sodium Hypochlorite 567

C: Nickel-Aluminum Alloy Reduction 575

D: Fenton’s Reagent 583

E: Photo-Fenton Reaction 587

F: Hydrogen Peroxide 591

G: Hydrogen Peroxide and Horseradish Peroxidase 593

H: Ozone 595

I: Hydroxylamine Degradation of b-Lactams 603

J: Miscellaneous Chemical Degradation Procedures 605

K: Photolytic Degradation Procedures 613

L: Decontamination of Aqueous Solutions 627

NONSPECIFIC METHODS FOR THE DESTRUCTION OF HAZARDOUS CHEMICALS IN THE LABORATORY 631

APPENDIXES 655

APPENDIX I: Procedures for Drying Organic Solvents 657

APPENDIX II: Safety Considerations with Potassium Permanganate 661

MOLECULAR FORMULA INDEX 671

CAS REGISTRY NUMBER INDEX 681

CROSS INDEX OF PHARMACEUTICAL NAMES 693

CROSS-INDEX OF NAMES FOR DYES AND BIOLOGICAL STAINS 729

NAME INDEX 757