What is included with this book?
Contributors | p. xi |
Preface | p. xiii |
Formation of the Murine Endoderm: Lessons from the Mouse, Frog, Fish, and Chick | p. 1 |
Introduction | p. 2 |
Endoderm Morphogenesis | p. 3 |
Molecular Control of Endoderm Formation | p. 17 |
Conclusions | p. 26 |
References | p. 27 |
Dividing the Tubular Gut: Generation of Organ Boundaries at the Pylorus | p. 35 |
Overview | p. 36 |
Paths to the Pylorus; Movements of Endodermal and Mesodermal Cells During Gut Tube Formation | p. 38 |
Organ Formation in the Pyloric Domain | p. 39 |
Molecular Patterning of the Gut Tube: Establishing Stomach and Intestinal Domains | p. 42 |
Establishing the Boundary Between Sox2- and Cdx2-Expressing Cells at the Pylorus | p. 49 |
Making the Pyloric Sphincter | p. 51 |
The Pylorus: A Compartment Boundary | p. 54 |
References | p. 57 |
Molecular Determinants of Metaplastic and Neoplastic Transformation in the Esophageal Epithelium | p. 63 |
Introduction | p. 64 |
Esophageal Mucosal Homeostasis and Response to Injury-The Framework | p. 64 |
Esophageal Mucosal Homeostasis-Molecular Determinants | p. 69 |
The Response to Injury, Metaplastic and Neoplastic Transformation in Esophagus-Molecular Derangements | p. 71 |
Implications of Molecular Determinants, Derangements, and Future Research | p. 84 |
References | p. 85 |
The Gastric Mucosa: Development and Differentiation | p. 93 |
Introduction | p. 94 |
Early Foregut Development | p. 94 |
Specification of the Stomach as a Separate Organ: An Overview | p. 95 |
Morphogenetic Codes Involved in Stomach Specification | p. 96 |
Transcription Factors | p. 101 |
Postnatal Gastric Development | p. 104 |
Adult Gastric Homeostasis | p. 106 |
Morphogenetic Pathways in Maintaining Adult Gastric Homeostasis | p. 109 |
Concluding Remarks | p. 110 |
References | p. 111 |
Oxyntic Atrophy, Metaplasia, and Gastric Cancer | p. 117 |
Organization of the Normal Gastric Oxyntic Mucosa | p. 118 |
The Development of Preneoplastic Metaplasia in the Stomach | p. 118 |
Parietal Cell Loss Leads to Metaplasia in Mice | p. 120 |
What Factors Regulate the Induction of Metaplasia? | p. 121 |
Cellular Origin of Metaplasia | p. 122 |
The Relationship of SPEM to Intestinal Metaplasia | p. 123 |
An Understanding of Metaplasia and the Development of Biomarkers for Preneoplasia | p. 125 |
Future Directions for Understanding Metaplasia in the Stomach | p. 127 |
References | p. 127 |
Hedgehog Signaling in Gastric Physiology and Cancer | p. 133 |
Introduction | p. 134 |
Hedgehog Gene Discovered in Mutagenesis Screens | p. 134 |
Hh Ligands | p. 135 |
Regulation of Shh Gene Expression | p. 136 |
Shh Processing | p. 138 |
Hh Receptors | p. 139 |
Primary Cilia and Hh Signaling | p. 140 |
Hh Signaling and Gastric Physiology | p. 142 |
References | p. 150 |
The Intestinal Stem Cell | p. 157 |
Introduction | p. 158 |
Monoclonality of Intestinal Crypts | p. 159 |
The Identity and Localization of Intestinal Stem Cells | p. 160 |
Other Putative Intestinal Stem Cell Markers | p. 162 |
The Intestinal Stem Cell Niche | p. 163 |
Evidence for a Nonmesenchymal Niche | p. 168 |
Intestinal Stem Cells as the Cell of Origin of Colorectal Cancer | p. 169 |
Conclusion | p. 170 |
References | p. 170 |
The Role of the Basement Membrane as a Modulator of Intestinal Epithelial-Mesenchymal Interactions | p. 175 |
Introduction | p. 176 |
Models of Epithelial-Mesenchymal Interactions in Developing Intestine | p. 177 |
The Intestinal Basement Membrane | p. 179 |
Influence of the Extracellular Matrix in Epithelial Differentiation | p. 184 |
Interplay Between Basement Membrane Molecules and Transcription Factors | p. 187 |
Involvement of Basement Membrane Proteins at the Epithelial-Mesenchymal Interface in the Intestine: Use of Gene Ablation Models | p. 192 |
Genetic Inactivation of Laminin Receptors Leads to Intestinal Abnormalities | p. 198 |
Conclusion and Future Directions | p. 199 |
Future Directions | p. 200 |
References | p. 201 |
Regulation of Gene Expression in the Intestinal Epithelium | p. 207 |
Introduction | p. 208 |
Hedgehog Signaling | p. 209 |
Forkhead Box Transcription Factors | p. 210 |
Homeobox Genes | p. 213 |
Parahox Genes | p. 213 |
GATA Transcription Factors | p. 215 |
WNT Signaling | p. 215 |
EPH/Ephrins | p. 217 |
SOX9 | p. 217 |
BMP Signaling | p. 218 |
PTEN/PI3K | p. 219 |
LKB1 Signaling | p. 219 |
K-RAS | p. 220 |
Notch Signaling | p. 220 |
HNF | p. 221 |
MATH 1 | p. 222 |
Integration of Notch and WNT Signaling | p. 222 |
Emerging Mechanisms of Gene Regulation | p. 222 |
References | p. 224 |
Cdx Genes, Inflammation, and the Pathogenesis of Intestinal Metaplasia | p. 231 |
Introduction: Metaplasia, Dysplasia, and Transdifferentiation | p. 232 |
The Cdx Genes and Their Roles During Normal Development | p. 234 |
Intestinal Metaplasia is a Pathological Condition in Humans | p. 237 |
Chronic Gastric Inflammation Gives Rise to Gastric Intestinal Metaplasia (GIM) | p. 239 |
Chronic Acid and Bile Reflux in the Esophagus Give Rise to Barrett's Esophagus | p. 240 |
Intestinal Metaplasia and Inflammation | p. 243 |
DNA Damage from Chronic Inflammation Promotes Metaplasia and Carcinogenesis | p. 245 |
The Roles of Cd×1 and Cd×2 in H. pylori Induced GIM | p. 247 |
The Roles of Cd×1 and Cd×2 in GERD-Induced Barrett's Esophagus | p. 251 |
Summary and Conclusions | p. 258 |
References | p. 259 |
Index | p. 271 |
Table of Contents provided by Ingram. All Rights Reserved. |
The New copy of this book will include any supplemental materials advertised. Please check the title of the book to determine if it should include any access cards, study guides, lab manuals, CDs, etc.
The Used, Rental and eBook copies of this book are not guaranteed to include any supplemental materials. Typically, only the book itself is included. This is true even if the title states it includes any access cards, study guides, lab manuals, CDs, etc.