Does Aging Stop?

by Mueller, Laurence D.; Rauser, Casandra L.; Rose, Michael R.

• ISBN13: 9780199754229
• ISBN10: 0199754225
• Format: Hardcover
• Copyright: 2011-07-29
• Publisher: Oxford University Press

Summary

Does Aging Stop?reveals the most paradoxical finding of recent aging research: the cessation of demographic aging. The authors show that aging stops at the level of the individual organism, and explain why evolution allows this. The implications of this counter-intuitive conclusion are profound, and aging research now needs to accept three uncomfortable truths. First, aging is not a cumulative physiological process. Second, the fundamental theory that is required to explain, manipulate, and probe the phenomena of aging comes from evolutionary biology. Third, strong-inference experimental strategies for aging must be founded in evolutionary research, not cell or molecular biology. The result of fifteen years of research bringing together new applications of evolutionary theory, new models for demography, and massive experimentation,Does Aging Stop?advances an entirely new foundation for the scientific study of aging.

Author Biography

Laurence Mueller is Professor of Ecology and Evolutionary Biology at the University of California, Irvine. Casandra Rauser is the Assistant Director of Research Development for the School of Biological Sciences at the University of California, Irvine Michael Rose is Professor of Biological Sciences at the University of California, Irvine and Director of the Network for Experimental Research on Evolution, University of California Systemwide.

Table of Contents

Figures	p. xiii
Tables	p. xvii
Introduction: A Third Phase of Life	p. 1
Discovery of Late Life	p. 7
Late Life Is Predicted by Hamiltonian Evolutionary Theory	p. 23
Late-Life Mortality and Fecundity Plateaus Evolve	p. 39
Genetics of Late Life Involve Antagonistic Pleiotropy	p. 56
Demography of Late Life with Lifelong Heterogeneity	p. 69
Evolution of Lifelong Heterogeneity	p. 80
Experimental Tests of Lifelong Heterogeneity	p. 87
Death Spirals	p. 105
Physiology of Late Life	p. 121
Late Life in Human Populations	p. 130
Aging Stops: Late Life, Evolutionary Biology, and Gerontology	p. 142
Appendix	p. 153
References	p. 185
Author Index	p. 199
Subject Index	p. 202
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