9780470633472

Drug Delivery Applications of Noninvasive Imaging Validation from Biodistribution to Sites of Action

by ;
  • ISBN13:

    9780470633472

  • ISBN10:

    0470633476

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2013-11-04
  • Publisher: Wiley

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Supplemental Materials

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Summary

Cost-effective strategies for designing novel drug delivery systems that target a broad range of disease conditions

In vivo imaging has become an important tool for the development of new drug delivery systems, shedding new light on the pharmacokinetics, biodistribution, bioavailability, local concentration, and clearance of drug substances for the treatment of human disease, most notably cancer. Written by a team of international experts, this book examines the use of quantitative imaging techniques in designing and evaluating novel drug delivery systems and applications.

Drug Delivery Applications of Noninvasive Imaging offers a full arsenal of tested and proven methods, practices and guidance, enabling readers to overcome the many challenges in creating successful new drug delivery systems. The book begins with an introduction to molecular imaging. Next, it covers:

  • In vivo imaging techniques and quantitative analysis
  • Imaging drugs and drug carriers at the site of action, including low-molecular weight radiopharmaceuticals, peptides and proteins, siRNA, cells, and nanoparticles
  • Applications of imaging techniques in administration routes other than intravenous injection, such as pulmonary and oral delivery
  • Translational research leading to clinical applications
  • Imaging drug delivery in large animal models
  • Clinical applications of imaging techniques to guide drug development and drug delivery

Chapters are based on a thorough review of the current literature as well as the authors' firsthand experience working with imaging techniques for the development of novel drug delivery systems.

Presenting state-of-the-technology applications of imaging in preclinical and clinical evaluation of drug delivery systems, Drug Delivery Applications of Noninvasive Imaging offers cost-effective strategies to pharmaceutical researchers and students for developing drug delivery systems that accurately target a broad range of disease conditions.

Author Biography

CHUN LI, PhD, is Professor and Ad Interim Chief, Chemistry Section, in the Department of Cancer Systems Imaging at the University of Texas MD Anderson Cancer Center. He is Associate Editor of Cancer Nanotechnology and a member of the editorial boards of American Journal of Nuclear Medicine and Molecular Imaging and Quantitative Imaging in Medicine and Surgery. Dr. Li has more than 120 peer-reviewed publications and holds twenty-eight patents.

MEI TIAN, MD, is Vice President of Hangzhou Binjiang Hospital and Professor of Diagnostic Imaging and Nuclear Medicine at The Second Hospital, Zhejiang University School of Medicine. Dr. Tian is also an editorial consultant for The Lancet. She is a member of the editorial boards of Journal of Nuclear Medicine, European Journal of Nuclear Medicine and Molecular Imaging, Nuclear Medicine Communications, and Oncology.

Table of Contents

Preface

Chapter 1: Introduction to Molecular Imaging
Vikas Kundra

Chapter 2: PET/SPECT: Instrumentation and Imaging Techniques
Yuan-Chuan Tai

Chapter 3: Photoacoustic Tomography and Its Application in Drug Delivery and Photothermal Therapy
Liang Song Lihong Wang

Chapter 4: Raman Microspectral Imaging for Label-Free Detection of Nanoparticle-Mediated Cellular and Sub-Cellular Drug Delivery
Tatyana Chernenko, Lara Milane, Max Diem, and Mansoor Amiji

Chapter 5: Quantitative Imaging in Drug Delivery
Kooresh Shoghi

Chapter 6: PET Imaging of Small-Molecular-Weight Drug Pharmacokinetics
Stephen M. Moerlein and Zhude Tu

Chapter 7: Imaging Peptides, Proteins, and Antibody Delivery
F. L. Giesel and C. Kratochwil

Chapter 8: In vivo imaging and delivery of siRNA
Zdravka Medarova and Anna Moore

Chapter 9: Imaging Cell Therapy
Yijie Linag and Jeff W.M. Bulte

Chapter 10: Radiolabeled Liposomes as Drug Delivery Nano-Theranostics
William T. Phillips, Ande Bao, Keitaro Sou, Shihong Li, and Beth Goins

Chapter 11: Polymeric Micelles as Imaging Agents and Drug Delivery Systems
Jun Zhao and Chun Li

Chapter 12: Perfluorocarbon Nanoparticles: Translating Bench Opportunities to the Clinic
G.M. Lanza, P. M. Winter, S. D. Caruthers, A. H. Schmieder, S. A. Wickline

Chapter 13: Cancer Theranostics with Hollow Gold Nanospheres
Wei Lu and Chun Li

Chapter 14: Imaging Pulmonary Drug Delivery
Stephen Newman

Chapter 15: In-vivo imaging for Validation of Oral Dose Performance
Fiona McInnes and Howard Stevens

Chapter 16: Role of Large Animal Models in Translational Studies of Imaging and Targeted Drug Delivery
Rajesh K. Uthamanthil and Mei Tian

Chapter 17: Imaging Transcatheter delivery to Liver Tumors
Adil AL-Nahhas, Meeran Naji, Imene Zerizer

Chapter 18: Direct Visualization of Therapeutic Radionuclides Distribution Using Nuclear Medicine Imaging: I-131 in Metastatic Thyroid Carcinoma
Ho Young Lee, June-Key Chung, So Won Oh, Jong Jin Lee, Keon Wook Kang, Do Joon Park, Bo Youn Cho, Myung Chul Lee

Chapter 19: Imaging Drug Delivery to the CNS Using Translational Positron Emission Tomography Studies
Chi-Ming Lee, Katarina Varnäs, and Lars Farde

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