Drug-Drug Interactions, Second Edition

by Rodrigues; A. David

• ISBN13: 9780849375934
• ISBN10: 0849375932
• Edition: 2nd
• Format: Hardcover
• Copyright: 2008-02-08
• Publisher: CRC Press

Summary

Authored by renowned leaders in the field, this comprehensive volume covers all aspects of drug-drug interactions, including preclinical, clinical, toxicological, and regulatory perspectives. Thoroughly updated, this second edition reflects the significant advances and includes extensive new material on: key interplay between transporters and enzymes in drug metabolism and drug interactions, the integral role of pharmacogenetics in metabolism-based drug-drug interactions, in vivo - in vitro correlations (reversible, mechanism-based inhibition, induction), in silico approaches enabling structure-activity and structure-function studies, high-throughput screening and GLP methods for evaluating drug interactions in vitro, the use of transgenic animal models to evaluate drug interactions. Providing helpful case examples and computer-aided modeling, Drug-Drug Interactions is filled with over 200 invaluable tables, equations, and figures to clarify key concepts, and incorporates critical new updated information. Book jacket.

Table of Contents

Preface	p. iii
Contributors	p. ix
Introducing Pharmacokinetic and Pharmacodynamic Concepts	p. 1
In Vitro Enzyme Kinetics Applied to Drug-Metabolizing Enzymes	p. 31
Human Cytochromes P450 and Their Role in Metabolism-Based Drug-Drug Interactions	p. 53
UDP-Glucuronosyltransferases	p. 87
Drug-Drug Interactions Involving the Membrane Transport Process	p. 135
In Vitro Models for Studying Induction of Cytochrome P450 Enzymes	p. 205
In Vitro Approaches for Studying the Inhibition of Drug-Metabolizing Enzymes and Identifying the Drug-Metabolizing Enzymes Responsible for the Metabolism of Drugs (Reaction Phenotyping) with Emphasis on Cytochrome P450	p. 231
The Role of P-Glycoprotein in Drug Disposition: Significance to Drug Development	p. 359
Cytochrome P450 Protein Modeling and Ligand Docking	p. 435
Role of the Gut Mucosa in Metabolically Based Drug-Drug Interactions	p. 471
Mechanism-Based Inhibition of Human Cytochromes P450: In Vitro Kinetics and In Vitro-In Vivo Correlations	p. 515
Transporter-Mediated Drug Interactions: Molecular Mechanisms and Clinical Implications	p. 545
Metabolism and Transport Drug Interaction Database: A Web-Based Research and Analysis Tool	p. 567
In Vivo Probes for Studying Induction and Inhibition of Cytochrome P450 Enzymes in Humans	p. 581
Drug-Drug Interactions: Clinical Perspective	p. 643
An Integrated Approach to Assessing Drug-Drug Interactions: A Regulatory Perspective	p. 665
Drug-Drug Interactions: Toxicological Perspectives	p. 687
Drug-Drug Interactions: Marketing Perspectives	p. 709
Index	p. 721
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