The Dynamic Bacterial Genome

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  • Edition: 1st
  • Format: Paperback
  • Copyright: 2010-02-04
  • Publisher: Cambridge University Press
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This book provides an in-depth analysis of the mechanisms and biological consequences of genome rearrangements in bacteria. Genome rearrangements are a result of the actions of discrete genetic elements such as conjugative transposons, plasmids, phage, and non-conjugative transposons. Bacteria also contain systems to mediate genetic rearrangements such as the general recombination pathway and specialized endogenous recombination mechanisms. The biological effects of these rearrangements are far-reaching and impact on bacterial virulence, antibiotic resistance and the ability of bacteria to avoid the attentions of the host immune system (e.g. antigenic variation). These rearrangements also provide the raw material on which natural selection can act. Each chapter examines the mechanisms involved in genome rearrangements and the direct biological consequences of these events. This book is written by leading research workers and is an invaluable resource for graduate students and researchers in this field.

Table of Contents

Basic Mechanisms of Genome Rearrangement in Bacteria
Mechanisms of homologous recombination in bacteria
Introduction to site-specific recombination
Site-specific recombination by the serine recombinases
Mobile introns and retroelements in bacteria
Horizontal Gene Transfer and Genome Plasticity
The F-Plasmid, a paradigm for bacterial conjugation
Molecular aspects of movement of conjugative transposons
Competence for genetic transformation
Biological Consequences of the Mobile Genome
Phase variation and antigenic variation
Pathogenicity islands
Biological consequences for bacteria of homologous recombination
Horizontal gene transfer and bacterial genomic legacies
Table of Contents provided by Publisher. All Rights Reserved.

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