| Acknowledgments | p. xi |
| Abbreviations and Acronyms | p. xiii |
| Introduction | p. 1 |
| Objectives | p. 4 |
| Audience | p. 5 |
| A Primer on Environmental Health | p. 5 |
| A Primer on Malnutrition | p. 6 |
| Content and Organization | p. 7 |
| Epidemiology | p. 15 |
| Environmental Health, Malnutrition, and Child Health | p. 17 |
| Environmental Factors, Exposure, and Transmission Pathways | p. 18 |
| Vicious Cycle of Infections and Malnutrition | p. 19 |
| Environmental Role in Early Childhood Health | p. 23 |
| Averting Cognition and Learning Impacts | p. 28 |
| Key Messages | p. 30 |
| Note | p. 30 |
| How Environmental Health Supplements Other Child Survival Strategies | p. 31 |
| Adding Value to Health Systems | p. 32 |
| Adapting Environmental Management Programs | p. 38 |
| Adjusting Infrastructure Strategies | p. 39 |
| Key Messages | p. 43 |
| Notes | p. 43 |
| Economics | p. 45 |
| How Large Is the Environmental Health Burden? | p. 47 |
| Burden of Disease | p. 48 |
| Environmental Health Burdens | p. 51 |
| Areas for Future Research | p. 58 |
| Key Messages | p. 59 |
| Notes | p. 59 |
| Estimating the Environmental Health Burden and Costs at the Country Level | p. 61 |
| Existing Practice in Environmental Health Valuation | p. 61 |
| Building New Estimates for Environmental Health Costs | p. 62 |
| Case Studies of Ghana and Pakistan | p. 64 |
| Results for Ghana and Pakistan | p. 66 |
| Conclusion | p. 77 |
| Next Steps | p. 79 |
| Key Messages | p. 81 |
| Notes | p. 81 |
| Experiences | p. 83 |
| Approaches to Environmental Health | p. 85 |
| History of Environmental Health | p. 86 |
| Agenda Falling through the Cracks | p. 88 |
| Environmental Health Experiences in Developing Countries | p. 90 |
| Understanding the Enabling Environment | p. 97 |
| Governance and Institutional Implications | p. 100 |
| Institutional Requirements for Successful Environmental Health Governance | p. 104 |
| A Critical Moment | p. 109 |
| Key Messages | p. 109 |
| Note | p. 110 |
| Conclusion | p. 111 |
| Contributions of This Report | p. 111 |
| Next Steps | p. 113 |
| Appendixes | |
| Technical Review of Cohort Studies | p. 117 |
| Background | p. 117 |
| Search Strategy and Selection Criteria | p. 118 |
| Findings and Discussion | p. 118 |
| Experimental Evidence from Deworming | p. 122 |
| Conclusions | p. 123 |
| Notes | p. 125 |
| Review of Studies on Nutritional Status and Education | p. 141 |
| Diarrhea and Education | p. 145 |
| Conclusions | p. 145 |
| Note | p. 146 |
| New Estimates for Burden of Disease from Water, Sanitation, and Hygiene | p. 147 |
| Computing Country-Level Environmental Health Burden of Disease | p. 151 |
| Mortality | p. 151 |
| Education | p. 160 |
| Notes | p. 170 |
| Methodological Aspects of Assessing Environmental Health Burden of Disease | p. 173 |
| From Relative Risks to Attributable Fractions | p. 173 |
| Dealing with Biased Estimates of Relative Risk | p. 176 |
| Notes | p. 177 |
| Monetary Valuation of the Cost of Environmental Health Risks | p. 179 |
| Note | p. 181 |
| References | p. 183 |
| Index | p. 201 |
| Boxes | |
| What Is Environmental Health? | p. 2 |
| Impact of Diarrhea on Child Malnutrition: Evidence from Research | p. 22 |
| Overweight Mothers Carrying Underweight Children | p. 25 |
| Why 50 Percent? Supporting Evidence from Recent Cohort Studies | p. 50 |
| Revisiting the "Asian Enigma" | p. 54 |
| The Mills-Reincke Phenomenon | p. 56 |
| Basic Indicators for Ghana and Pakistan | p. 65 |
| Attributable Fractions and Burden of Disease When Multiple Risk Factors Are Present | p. 75 |
| How Policy-Makers Should Interpret These Results | p. 80 |
| Combating Disease through Improved Milk | p. 87 |
| Mexico: Multisectorality through a Diagonal Approach | p. 92 |
| Thailand's National Nutrition Program | p. 93 |
| Ethiopia: The Toilet Revolution | p. 95 |
| Vietnam's Dengue Program | p. 97 |
| Atrophy of Environmental Health Functions in India | p. 101 |
| Institutional Evolution of Environmental Health: The Case of Ethiopia | p. 102 |
| Figures | |
| The F-Diagram: Transmission Routes for Infection | p. 19 |
| Relationship between Nutrition and Infection | p. 20 |
| Environmental Health Inputs and Health Outcomes in the Child's Life Cycle | p. 24 |
| The Window of Opportunity for Addressing Undernutrition | p. 27 |
| Range of Preventive Activities in Child Survival | p. 32 |
| The Health Effects of Environmental Risks Factors | p. 52 |
| Water-Related (WSH plus WRM) Burden of Disease in Children under Five Attributable to Environmental Risk Factors by WHO Region, 2002 | p. 53 |
| Mills-Reincke Ratios for Subregions | p. 55 |
| Cost of Environmental Health Risks | p. 63 |
| Weight-for-Age Distribution of Children in Ghana and Pakistan | p. 70 |
| Two-Week Diarrheal Prevalence Rate by Age and Underweight Status in Ghana and Pakistan | p. 71 |
| Underweight Malnutrition Rates in Children with and without Diarrheal Infections in Ghana and Pakistan | p. 73 |
| Calculating Revised Estimates (Indirect and Direct Effects) | p. 74 |
| Final Results of Ghana and Pakistan Case Studies | p. 78 |
| Summary of the Methodology | p. 152 |
| Exposure Categories | p. 155 |
| Exposure Categories, Population Shares, and Relative Risks of ALRI in Ghana | p. 159 |
| Tables | |
| Millennium Development Goals and Environmental Health | p. 3 |
| Annual Cost of Direct and Indirect Impact of Environmental Risk Factors in 2005 | p. 10 |
| Water-Related Transmission Routes and Disease Outcome | p. 18 |
| Impact of Infection on Nutritional Status | p. 21 |
| Role of Environmental Health in Supplementing Health System Strategies | p. 33 |
| Environmental Risk Factors and Related Diseases Included in the Comparative Risk Assessment | p. 49 |
| Environmentally Attributable Fractions of Child Mortality, Keeping Malnutrition Unchanged | p. 67 |
| Estimated Mortality in Under-Five Children from Environmental Risk Factors, 2005 | p. 67 |
| Malnutrition Rates in Children under the Age of Five | p. 68 |
| Malnutrition-Attributable Fractions of Child Mortality | p. 70 |
| Environmentally Attributable Fractions and Child Mortality with Malnutrition-Mediated Effects | p. 74 |
| Effects of Malnutrition on Education | p. 76 |
| Annual Cost of Direct and Indirect Effect of Environmental Risk Factors in 2005 | p. 79 |
| Cohort Follow-up Studies Relating Infectious Disease and Nutritional Status of Children in Developing Countries | p. 126 |
| Studies of the Effects of Malnutrition on Educational Outcomes | p. 142 |
| Burden of Disease (in DALYs) in Children under Five Years Attributable to Water, Sanitation, and Hygiene, by World Health Organization Subregions, 2002 | p. 148 |
| Causes of Death and Risk Factors Considered in this Study | p. 152 |
| Estimating the Cost of Environmental Health Risks: Information Types and Sources | p. 154 |
| Relative Risks by Exposure Categories, Assuming Cox Hazard Model | p. 156 |
| Weight Gain Retardation Factors by Age and z-Score | p. 157 |
| Weight for Age in Children under Five: Current Rates and Estimated Rates in the Absence of Diarrheal Infections in Ghana | p. 158 |
| Estimated Mortality in Children under Five from Environmental Risk Factors, Ghana | p. 159 |
| Estimated Annual Cost of Education Outcomes from Stunting and Share from Environmental Factors in Ghana | p. 161 |
| Height Growth Retardation Factors by Age and z-Score | p. 162 |
| Height-for-Age Rates in Children under Five: Current Rates and Estimated Rates in the Absence of Diarrheal Infections in Ghana | p. 162 |
| Parameter Values Applied in Estimation of Income Losses | p. 165 |
| Income Distribution across Malnutrition Categories and Wealth Quintiles in Ghana | p. 167 |
| Annual Cost of Environmental Factors (Percentage of GDP in 2005), Using 3 Percent Discount Rate | p. 168 |
| Annual Cost of Environmental Factors (Percentage of GDP in 2005), Using 5 Percent Discount Rate | p. 169 |
| Environmental Risk Factors and Related Diseases Included in the WHO Comparative Risk Assessment | p. 174 |
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