Epigenetics, Nuclear Organization & Gene Function With implications of epigenetic regulation and genetic architecture for human development and health

by Lucchesi, John C.

• ISBN13: 9780198831211
• ISBN10: 0198831218
• Format: Paperback
• Copyright: 2019-03-09
• Publisher: Oxford University Press

Author Biography

John C. Lucchesi, Asa Griggs Candler Professor Emeritus, Department of Biology, Emory University, Atlanta GA, USA

John Lucchesi obtained a Ph.D. in Genetics from the University of California at Berkeley. Following postdoctoral training in the Institute of Molecular Biology at the University of Oregon, he joined the faculty of the University of North Carolina in Chapel Hill, where he rose to the rank of Cary C. Boshamer Professor of Biology and Genetics. He was appointed Adjunct Professor of Genetics at Duke University and was named Senior Fellow of Churchill College, Cambridge University, UK. In 1990, he joined the faculty of the Biology Department at Emory University as Asa G. Candler Professor of Biology and Chair. Dr Lucchesi is a fellow of the AAAS, a former President of the Genetics Society of America and was named Vice-President of the XVII International Congress of Genetics. His research laboratory has focused on the regulation of transcription, the functional architecture of chromatin and the genetic regulation of development.

Table of Contents

Part I
An introduction to epigenetics and epigenetic regulation
1. Epigenetic phenomena in fungi, plants and animals
2. The basic structure of chromatin
3. The basic mechanism of gene transcription
Part II
Transcription is regulated by epigenetic mechanisms
4. Chromatin modifications and remodeling
5. Epigenetic chromatin changes and the transcription cycle
6. The role of non-coding RNAs
7. Maintenance of the active and inactive states
8. DNA methylation and gene expression
9. Regulation of domains and whole chromosomes
Part III
The interplay between transcription and nuclear structure
10. Architectural organization of the genome
11. The nuclear envelope
12. The nucleolus
13. Nuclear bodies
Part IV
Inheritance of chromatin structure and functional states
14. Chromosome replication and genomic stability
15. DNA repair and genomic stability
16. Inheritance of chromatin modifications through the cell cycle
17. Stem cells
18. Nuclear reprogramming and induced pluripotency
19. Transgenerational inheritance of epigenetic traits
Part V
Epigenetics, human health and development
20. Aging, cellular senescence and cancer: The role of genomic instability, cellular homeostasis and telomeres
21. Aging, cellular senescence and cancer: Epigenetic alterations and nuclear remodeling
22. Developmental systems and their dysfunction