Epithelial Transport and Barrier Function : Pathomechanisms in Gastrointestinal Disorders

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  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2001-01-01
  • Publisher: New York Academy of Sciences
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Table of Contents

Prefacep. xi
Expression of Transporters and Regulation of Ion Transport
Expression and Function of Na[superscript +]HCO[subscript 3 superscript -] Cotransporters in the Gastrointestinal Tractp. 1
Characterization and Molecular Localization of Anion Transporters in Colonic Epithelial Cellsp. 15
Short-Term Regulation of NHE3 by EGF and Protein Kinase C but Not Protein Kinase A Involves Vesicle Trafficking in Epithelial Cells and Fibroblastsp. 30
Cl-Dependent Na-H Exchange: A Novel Colonic Crypt Transport Mechanismp. 43
Coupling between Na[superscript +], Sugar, and Water Transport across the Intestinep. 54
Regulation of Chloride Secretion: Novel Pathways and Messengersp. 67
Neurotransmitters in Neuronal Reflexes Regulating Intestinal Secretionp. 77
Extended Abstracts
Three 5'-Variant mRNAs of Anion Exchanger AE2 in Stomach and Intestine of Mouse, Rabbit, and Ratp. 81
Differential Regulation of ENaC by Aldosterone in Rat Early and Late Distal Colonp. 92
Epithelial Phosphate Transporters in Small Ruminantsp. 95
Inflammatory Mediators Influencing Submucosal Secretory Reflexesp. 98
Tumor Necrosis Factor-[alpha] Potentiates Ion Secretion Induced by Muscarinic Receptor Activation in the Human Intestinal Epithelial Cell Line HT29cl. 19Ap. 102
Investigation of Motility and Secretion in Perfused Guinea Pig Colon ex Situp. 107
Stimulation by Portal Insulin of Intestinal Glucose Absorption via Hepatoenteral Nerves and Prostaglandin E[subscript 2] in the Isolated, Jointly Perfused Small Intestine and Liver of the Ratp. 111
Effects of HIV Protease Inhibitors on Barrier Function in the Human Intestinal Cell Line HT-29/B6p. 117
Induction of Endothelial Barrier Function in Vitrop. 123
Structure and Regulation of the Intestinal Barrier
The Structure and Function of Claudins, Cell Adhesion Molecules at Tight Junctionsp. 129
Intestinal Cell Adhesion Molecules: Liver-Intestine Cadherinp. 136
Molecular Diversity of Plaques of Epithelial-Adhering Junctionsp. 144
Neutrophil Migration across Intestinal Epitheliump. 151
Expression and Function of Death Receptors and Their Natural Ligands in the Intestinep. 162
Role of M Cells in Intestinal Barrier Functionp. 171
Models for Studying Disturbed Transport and Barrier Properties
Nutrient Transporter Function Studied in Heterologous Expression Systemsp. 184
Epithelial Barrier Defects in HT-29/B6 Colonic Cell Monolayers Induced by Tumor Necrosis Factor-[alpha]p. 193
Enhanced Expression of iNOS in Inflamed Colons of IL-2-Deficient Mice Does Not Impair Colonic Epithelial Barrier Functionp. 204
Regulation of Intercellular Tight Junctions by Zonula Occludens Toxin and Its Eukaryotic Analogue Zonulinp. 214
Analysis of Low-Molecular-Weight GTP-Binding Proteins in Two Functionally Different Intestinal Epithelial Cell Linesp. 223
Increased Tight Junction Permeability Can Result from Protein Kinase C Activation/Translocation and Act as a Tumor Promotional Event in Epithelial Cancersp. 231
Stress-Induced Decrease of the Intestinal Barrier Function: The Role of Muscarinic Receptor Activationp. 237
Immunologically Mediated Transport of Ions and Macromoleculesp. 247
Extended Abstracts
Carbachol-Induced Ca[superscript 2+] Entry into Rat Colonic Epitheliump. 260
Effects of Endotoxin on Human Large Intestinep. 264
Increased Paracellular Macromolecular Transport and Subnormal Glucose Uptake in Duodenal Biopsies of Patients with Microvillus Inclusion Disease: Comparisons to Other Chronic Diarrhea Patients and to Non-diarrhea Patientsp. 267
Apoptosis and Intestinal Barrier Functionp. 270
p53-Independent Apoptosis Induced by Menadione in the Human Colon Carcinoma Cell Line Caco-2p. 275
Epidermal Growth Factor, Polyamines, and Epithelial Remodeling in Caco-2 Cellsp. 279
Effect of TNF[alpha] and IFN[gamma] on Epithelial Barrier Function in Rat Rectum in Vitrop. 282
Colectomy and Ileal Pouch: Transport and Barrier in Pouchitisp. 287
Diarrheal Mechanisms in Gastrointestinal Diseases
Mechanisms of Epithelial Barrier Impairment in HIV Infectionp. 293
Cytokine-Induced Alteration of the Epithelial Barrier to Food Antigens in Diseasep. 304
Epithelial Barrier and Transport Function of the Colon in Ulcerative Colitisp. 312
Diarrhea in Ulcerative Colitis: The Role of Altered Colonic Sodium Transportp. 327
Barrier Dysfunction and Crohn's Diseasep. 333
Mechanisms of Cholera Toxin-Induced Diarrheap. 339
Effects of Clostridium difficile Toxins on Epithelial Cell Barrierp. 347
Ion Transport during Growth and Differentiationp. 357
Index of Contributorsp. 373
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