Essential Cell Biology

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  • Edition: 2nd
  • Format: Paperback
  • Copyright: 2003-09-25
  • Publisher: Garland Science
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Author Biography

Bruce Alberts received his Ph.D. from Harvard University and is President of the National Academy of Sciences and Professor of Biochemistry and Biophysics at the University of California, San Francisco Dennis Bray received his Ph.D. from Massachusetts Institute of Technology and is currently a Medical Research Council Fellow in the Department of Zoology, University of Cambridge Karen Hopkin received her Ph.D. in biochemistry from the Albert Einstein College of Medicine in the Bronx and is a science writer in Cambridge, Massachusetts Alexander Johnson received his Ph.D. from Harvard University and is a Professor of Microbiology and Immunology and Co-Director of the Biochemistry and Molecular Biology Program at the University of California, San Francisco. Julian Lewis received his D.Phil. from the University of Oxford and is a Principal Scientist at the London Research Institute of Cancer Research UK Martin Raff received his M.D. from McGill University and is at the Medical Research Council Laboratory for Molecular Cell Biology and Cell Biology Unit and in the Biology Department at University College London Keith Roberts received his Ph.D. from the University of Cambridge and is Associate Research Director at the John Innes Centre, Norwich Peter Walter received his Ph.D. from The Rockefeller University in New York and is Professor and Chairman of the Department of Biochemistry and Biophysics at the University of California, San Francisco, and an Investigator of the Howard Hughes Medical Institute

Table of Contents

Introduction to Cellsp. 1
Light and electron microscopyp. 8
Cells: the principal features of animal, plant, and bacterial cellsp. 25
How We Know: Life's common mechanismsp. 30
Chemical Components of Cellsp. 39
How We Know: What are macromolecules?p. 60
Chemical bonds and groupsp. 66
The chemical properties of waterp. 68
An outline of some of the types of sugarsp. 70
Fatty acids and other lipidsp. 72
The 20 amino acids found in proteinsp. 74
A survey of the nucleotidesp. 76
The principal types of weak noncovalent bondsp. 78
Energy, Catalysis, and Biosynthesisp. 83
Free energy and biological reactionsp. 96
How We Know: Using kinetics to model and manipulate metabolic pathwaysp. 103
Protein Structure and Functionp. 119
A few examples of some general protein functionsp. 120
How We Know: Probing protein structurep. 129
Four different ways of depicting a small proteinp. 132
Cell breakage and initial fractionation of cell extractsp. 160
Protein separation by chromatographyp. 162
Protein separation by electrophoresisp. 163
Making and using antibodiesp. 164
DNA and Chromosomesp. 169
How We Know: Genes are made of DNAp. 172
DNA Replication, Repair, and Recombinationp. 195
How We Know: Finding replication originsp. 198
From DNA to Protein: How Cells Read the Genomep. 229
How We Know: Cracking the genetic codep. 246
Control of Gene Expressionp. 267
How We Know: Gene regulation--the story of evep. 282
How Genes and Genomes Evolvep. 293
How We Know: Counting genesp. 314
Manipulating Genes and Cellsp. 323
How We Know: Sequencing the human genomep. 334
Membrane Structurep. 365
How We Know: Measuring membrane flowp. 384
Membrane Transportp. 389
How We Know: Squid reveal secrets of membrane excitabilityp. 414
How Cells Obtain Energy from Foodp. 427
Details of the 10 steps of glycolysisp. 432
How We Know: Unraveling the citric acid cyclep. 442
The complete citric acid cyclep. 450
Energy Generation in Mitochondria and Chloroplastsp. 453
How We Know: How chemiosmotic coupling drives ATP synthesisp. 460
Redox potentialsp. 471
Intracellular Compartments and Transportp. 497
How We Know: Tracking protein and vesicle transportp. 520
Cell Communicationp. 533
How We Know: Untangling cell signaling pathwaysp. 561
Cytoskeletonp. 573
How We Know: Pursuing motor proteinsp. 586
Cell-Cycle Control and Cell Deathp. 611
How We Know: Discovery of cyclins and Cdksp. 618
Cell Divisionp. 637
The principal stages of M phase in an animal cellp. 642
How We Know: Building the mitotic spindlep. 646
Genetics, Meiosis, and the Molecular Basis of Heredityp. 659
How We Know: Reading genetic linkage mapsp. 682
Some essentials of classical geneticsp. 685
Tissues and Cancerp. 697
The cell types and tissues from which higher plants are constructedp. 700
How We Know: Making sense of the genes that are critical for cancerp. 734
Answers to Questionsp. A:1
Glossaryp. G:1
Indexp. I:1
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