Essentials of Pathophysiology Concepts of Altered Health States

by Porth, Carol Mattson

• ISBN13: 9780781770873
• ISBN10: 0781770874
• Edition: 2nd
• Format: Paperback
• Copyright: 2006-02-24
• Publisher: LWW

Summary

Pathophysiology can be a complex and intimidating subject, yet no text makes it easier to understand than the new edition of Essentials of Pathophysiology: Concepts of Altered Health States.

Table of Contents

Introduction to Pathophysiology	xxxi
UNIT I Cell and Tissue Function
Cell Structure and Function	1	(28)
Edward W. Carroll
Functional Components of the Cell	1	(6)
Cell Metabolism and Energy Sources	7	(4)
Cell Membrane Transport, Signal Transduction, and Generation of Membrane Potentials	11	(7)
Body Tissues	18	(11)
Cellular Responses to Stress, Injury, and Aging	29	(16)
Cellular Responses to Stress	29	(5)
Cell Injury and Death	34	(8)
Cellular Aging	42	(3)
Genetic Control of Cell Function and Inheritance	45	(16)
Edward W. Carroll
Genetic Control of Cell Function	45	(6)
Chromosomes	51	(3)
Patterns of Inheritance	54	(2)
Gene Technology	56	(5)
Genetic and Congenital Disorders	61	(18)
Genetic and Chromosomal Disorders	61	(10)
Disorders Due to Environmental Influences	71	(4)
Prenatal Diagnosis	75	(4)
Neoplasia: A Disorder of Cell Proliferation and Differentiation	79	(26)
Kerry Twite
Concepts of Cell Growth	79	(5)
Benign and Malignant Neoplasms	84	(5)
Etiology of Cancer	89	(6)
Clinical Manifestations	95	(1)
Diagnosis and Treatment	96	(5)
Childhood Cancers	101	(4)
UNIT II Integrative Body Functions
Disorders of Fluid, Electrolyte, and Acid-Base Balance	105	(46)
Glenn Matfin
Carol M. Porth
Composition and Compartmental Distribution of Body Fluids	106	(7)
Sodium and Water Balance	113	(9)
Potassium Balance	122	(5)
Calcium and Magnesium Balance	127	(8)
Acid-Base Balance	135	(16)
Stress and Adaptation	151	(14)
Mary Pat Kunert
Stress and Adaptation	152	(7)
Disorders of the Stress Response	159	(6)
Alterations in Body Nutrition	165	(14)
Joan Pleuss
Regulation of Food Intake and Energy Metabolism	165	(5)
Overnutrition and Obesity	170	(3)
Undernutrition	173	(6)
UNIT III Hematopoietic Function
Disorders of White Blood Cells and Lymphoid Tissues	179	(18)
Kerry Twite
Kathryn J. Gaspard
Hematopoietic and Lymphoid Tissue	179	(3)
Non-neoplastic Disorders of White Blood Cells	182	(3)
Neoplastic Disorders of Hematopoietic and Lymphoid Origin	185	(12)
Alterations in Hemostasis	197	(14)
Kathryn J. Gaspard
Mechanisms of Hemostasis	197	(6)
Hypercoagulability States	203	(1)
Bleeding Disorders	204	(7)
The Red Blood Cell and Alterations in Oxygen Transport	211	(18)
Kathryn J. Gaspard
The Red Blood Cell	211	(5)
Anemia	216	(8)
Polycythemia	224	(1)
Age-Related Changes in Red Blood Cells	224	(5)
UNIT IV Infection, Inflammation, and Immunity
Mechanisms of Infectious Disease	229	(18)
Wm. Michael Dunne
Infectious Diseases	229	(7)
Mechanisms of Infection	236	(5)
Diagnosis and Treatment of Infectious Diseases	241	(3)
Bioterrorism and Emerging Global Infectious Diseases	244	(3)
The Immune Response	247	(22)
Cynthia V. Sommer
The Immune System	247	(14)
Effector Responses of the Immune System	261	(5)
Developmental Aspects of the Immune System	266	(3)
Inflammation, Tissue Repair, and Fever	269	(24)
Cynthia V. Sommer
Carol M. Porth
The Inflammatory Response	269	(9)
Tissue Repair and Wound Healing	278	(7)
Temperature Regulation and Fever	285	(8)
Alterations in the Immune Response	293	(26)
Carol M. Porth
Kathleen Sweeney
Hypersensitivity Disorders	293	(7)
Autoimmune Disease	300	(2)
Transplantation Immunopathology	302	(2)
Immunodeficiency Disorders	304	(15)
UNIT V Circulatory Function
Control of Cardiovascular Function	319	(26)
Glenn Matfin
Carol M. Porth
Organization of the Circulatory System	319	(2)
Principles of Blood Flow	321	(4)
The Heart as a Pump	325	(12)
Blood Vessels and the Peripheral Circulation	337	(6)
Autonomic Nervous System Control of Circulatory Function	343	(2)
Disorders of Blood Flow and Blood Pressure	345	(40)
Carol M. Porth
Glenn Matfin
Blood Vessel Structure and Function	345	(2)
Disorders of the Arterial Circulation	347	(13)
Disorders of Arterial Blood Pressure	360	(16)
Disorders of the Venous Circulation	376	(9)
Disorders of Cardiac Function	385	(34)
Glenn Matfin
Carol M. Porth
Disorders of the Pericardium	385	(3)
Coronary Heart Disease	388	(10)
Myocardial and Endocardial Diseases	398	(7)
Valvular Heart Disease	405	(4)
Heart Disease in Infants and Children	409	(10)
Heart Failure and Circulatory Shock	419	(24)
Carol M. Porth
Glenn Matfin
Heart Failure	419	(11)
Circulatory Failure (Shock)	430	(7)
Circulatory Failure in Children and the Elderly	437	(6)
UNIT VI Respiratory Function
Control of Respiratory Function	443	(24)
Structural Organization of the Respiratory System	443	(6)
Exchange of Gases Between the Atmosphere and the Lungs	449	(7)
Exchange and Transport of Gases	456	(7)
Control of Breathing	463	(4)
Respiratory Tract Infections, Neoplasia, and Childhood Disorders	467	(24)
Respiratory Tract Infections	467	(12)
Cancer of the Lung	479	(2)
Respiratory Disorders in Children	481	(10)
Disorders of Ventilation and Gas Exchange	491	(30)
Disorders of Lung Inflation	491	(4)
Obstructive Airway Disorders	495	(13)
Chronic Interstitial Lung Diseases	508	(2)
Pulmonary Vascular Disorders	510	(4)
Respiratory Failure	514	(7)
UNIT VII Kidney and Urinary Tract Function
Control of Kidney Function	521	(16)
Kidney Structure and Function	522	(12)
Tests of Renal Function	534	(3)
Disorders of Renal Function	537	(22)
Congenital Disorders of the Kidneys	537	(3)
Obstructive Disorders	540	(4)
Urinary Tract Infections	544	(5)
Disorders of Glomerular Function	549	(5)
Tubulointerstitial Disorders	554	(2)
Neoplasms	556	(3)
Renal Failure	559	(16)
Acute Renal Failure	559	(4)
Chronic Renal Failure	563	(8)
Renal Failure in Children and Elderly Persons	571	(4)
Disorders of Urine Elimination	575	(14)
Control of Urine Elimination	575	(4)
Alterations in Bladder Function	579	(7)
Cancer of the Bladder	586	(3)
UNIT VIII Gastrointestinal and Hepatobiliary Function
Structure and Function of the Gastrointestinal System	589	(16)
Structure and Organization of the Gastrointestinal Tract	590	(3)
Innervation and Motility	593	(4)
Hormonal and Secretory Function	597	(3)
Digestion and Absorption	600	(2)
Anorexia, Nausea, and Vomiting	602	(3)
Disorders of Gastrointestinal Function	605	(26)
Disorders of the Esophagus	605	(3)
Disorders of the Stomach	608	(5)
Disorders of the Small and Large Intestines	613	(18)
Disorders of Hepatobiliary and Exocrine Pancreas Function	631	(28)
The Liver and Hepatobiliary System	631	(7)
Disorders of Hepatic and Biliary Function	638	(13)
Disorders of the Gallbladder and Exocrine Pancreas	651	(8)
UNIT IX Endocrine System
Organization and Control of the Endocrine System	659	(14)
Glenn Matfin
Safak Guven
Julie A. Kuenzi
The Endocrine System	659	(14)
Disorders of Endocrine Function	673	(26)
Glenn Matfin
Safak Guven
Julie A. Kuenzi
General Aspects of Altered Endocrine Function	673	(1)
Pituitary and Growth Disorders	674	(8)
Thyroid Disorders	682	(7)
Disorders of Adrenal Cortical Function	689	(10)
Diabetes Mellitus and the Metabolic Syndrome	699	(26)
Glenn Matfin
Julie A. Kuenzi
Safak Guven
Hormonal Control of Glucose, Fat, and Protein Metabolism	699	(6)
Diabetes Mellitus	705	(20)
UNIT X Nervous System
Organization and Control of Neural Function	725	(34)
Edward W. Carroll
Robin L. Curtis
Nervous Tissue Cells	725	(4)
Nerve Cell Communication	729	(5)
Developmental Organization of the Nervous System	734	(8)
Spinal Cord and Brain	742	(9)
The Autonomic Nervous System	751	(8)
Disorders of Somatosensory Function and Pain	759	(28)
Elizabeth C. Devine
Organization and Control of Somatosensory Function	759	(6)
Pain	765	(10)
Alterations in Pain Sensitivity and Special Types of Pain	775	(3)
Headache	778	(3)
Pain in Children and Older Adults	781	(6)
Disorders of Neuromuscular Function	787	(36)
Organization and Control of Motor Function	787	(9)
Skeletal Muscle, Neuromuscular Junction, and Peripheral Nerve Disorders	796	(8)
Basal Ganglia and Cerebellum Disorders	804	(4)
Upper Motor Neuron Disorders	808	(15)
Disorders of Brain Function	823	(38)
Diane Book
Mechanisms and Manifestations of Brain Injury	823	(15)
Cerebrovascular Disease	838	(9)
Infections and Brain Tumors	847	(4)
Seizure Disorders	851	(3)
Dementias	854	(7)
Disorders of Special Sensory Function: Vision, Hearing, and Vestibular Function	861	(40)
Edward W. Carroll
Susan A. Fontana
The Eye and Disorders of Vision	861	(21)
The Ear and Disorders of Auditory Function	882	(10)
Disorders of Vestibular Function	892	(9)
UNIT XI Genitourinary and Reproductive Function
Disorders of the Male Genitourinary System	901	(24)
Glenn Matfin
Physiologic Basis of Male Reproductive Function	901	(6)
Disorders of the Penis, the Scrotum and Testes, and the Prostate	907	(12)
Disorders in Childhood and Aging Changes	919	(6)
Disorders of the Female Genitourinary System	925	(30)
Patricia McCowen Mehring
Structure and Function of the Female Reproductive System	925	(6)
Disorders of the Female Reproductive Organs	931	(13)
Menstrual Disorders	944	(4)
Disorders of the Breast	948	(7)
Sexually Transmitted Diseases	955	(14)
Patricia McCowen Mehring
Infections of the External Genitalia	955	(4)
Vaginal Infections	959	(2)
Urogenital-Systemic Infections	961	(8)
UNIT XII Musculoskeletal Function
Structure and Function of the Skeletal System	969	(12)
Characteristics of Skeletal Tissue	970	(5)
Skeletal Structures	975	(6)
Disorders of the Skeletal System: Trauma, Infection, and Childhood Disorders	981	(34)
Kathleen E. Gunta
Injury and Trauma of Musculoskeletal Structures	981	(14)
Infections and Osteonecrosis	995	(4)
Neoplasms	999	(3)
Skeletal Disorders in Children	1002	(13)
Disorders of the Skeletal System: Metabolic and Rheumatic Disorders	1015	(32)
Debra Bancroft Rizzo
Kathleen E. Gunta
Metabolic Bone Disease	1015	(10)
Rheumatic Disorders	1025	(15)
Rheumatic Diseases in Children and the Elderly	1040	(7)
UNIT XIII Integumentary Function
Structure and Function of the Skin	1047	(10)
Gladys Simandl
Structure of the Skin	1047	(5)
Manifestations of Skin Disorders	1052	(5)
Disorders of the Skin	1057	(34)
Gladys Simandl
Primary Disorders of the Skin	1057	(15)
Ultraviolet Radiation, Thermal, and Pressure Injury	1072	(7)
Nevi and Skin Cancers	1079	(4)
Age-Related Skin Manifestations	1083	(8)
Glossary	1091	(10)
Appendix A: Laboratory Values	1101	(2)
Index	1103