Evolution in Health and Disease

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  • Edition: 2nd
  • Format: Hardcover
  • Copyright: 2008-01-10
  • Publisher: Oxford University Press

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In this fully revised and updated edition, the editors have integrated a completely new set of contributions from the leading researchers in the field to describe the latest research in evolutionary medicine, providing a fresh summary of this rapidly expanding field 10 years after itspredecessor was first compiled. It continues to adopt a broad approach to the subject, drawing on medically relevant research from evolutionary genetics, human behavioural ecology, evolutionary microbiology (especially experimental evolution of virulence and resistance), the evolution of aging anddegenerative disease, and other aspects of biology or medicine where evolutionary approaches make important contributions.iEvolution in Health and Disease/i describes how evolutionary thinking gives valuable insights and fresh perspectives into human health and disease, establishing evolutionary biology as an essential complementary science for medicine. Integrating evolutionary thought into medical research andpractice helps to explain the origins of many medical conditions, including diabetes, obesity, cardiovascular disease, asthma, allergies, other autoimmune diseases, and aging. It also provides life-saving insights into the evolutionary responses of pathogens to antibiotics, vaccinations, and otherhuman interventions. Why do we grow old? How can we stay healthy as we age? The book discusses these and many other fascinating questions, as well as suggesting exciting possibilities for future treatment and research.This research level text is suitable for graduate level students and researchers in the fields of evolutionary (Darwinian) medicine, evolutionary biology, anthropology, developmental biology and genetics. It will also be of relevance and use to medical researchers and doctors.

Author Biography

Professor Stearns specializes in life history evolution, which links the fields of ecology and evolutionary biology, in evolutionary medicine, and in evolutionary functional genomics. He came to Yale in 2000 from the University of Basel, Switzerland, where he had been professor of zoology since 1983 and held several administrative posts. Prior to moving to Basel he was an assistant professor in the Biology Department at Reed College in Oregon. Born in Hawaii and a 1967 graduate of Yale College, Stearns earned a M.S. from the University of Wisconsin and a Ph.D. from the University of British Columbia.
Professor Koella's interests lie in the coevolution of parasites and hosts. He specializes in the evolutionary epidemiology of malaria and in the application of evolutionary ideas to the control of malaria. After obtaining a Masters' in mechanical engineering at the ETH Zurich and a PhD in evolutionary biology at the University of Basel he worked for several years at the Swiss Tropical Institute Basel as a malaria epidemiologist before moving on to positions in Switzerland, Denmark and France. He arrived at Imperial College in 2005 as a Chair in Epidemiology.

Table of Contents

Introducing evolutionary thinking for medicine
The history and variation of human genes
Global spatial patterns of infectious diseases and human evolution
Medically relevant variation in the human genome
Health consequences of ecogenetic variation
Human genetic variation of medical significance
Natural selection and evolutionary conflicts
Intimate relations: evolutionary conflicts of pregnancy and childhood
How hormones mediate tradeoffs in human health and disease
Functional significance of MHC variation in mate choice, reproductive outcome, and disease risk
Perspectives on human health and disease from evolutionary and behavioral ecology
Pathogens: resistance, virulence, variation, and emergence
The ecology and evolution of antibiotic resistant bacteria
Pathogen evolution in a vaccinated world
The evolution and expression of virulence
Evolutionary origins of diversity in human viruses
The population structure of pathogenic bacteria
Whole-genome analysis of pathogen evolution
Emergence of new infectious diseases
Evolution of parasites
Noninfectious and degenerative disease
Evolutionary biology as a foundation for studying aging and aging-related disease
Evolution, developmental plasticity, and metabolic disease
Lifestyle, diet, and disease: comparative perspectives on the determinants of chronic health risks
Cancer: evolutionary origins of vulnerability
Cancer as a microevolutionary process
The evolutionary context of human aging and degenerative disease
Table of Contents provided by Publisher. All Rights Reserved.

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