Extracellular Matrix Biology

by Hynes, Richard O.; Yamada, Kenneth M.

• ISBN13: 9781936113385
• ISBN10: 1936113384
• Format: Hardcover
• Copyright: 2011-10-31
• Publisher: Cold Spring Harbor Laboratory Press

Summary

In most tissues, cells are surrounded by an extracellular matrix (ECM) containing proteins such as collagen, laminin, and fibronectin. The ECM plays an important role in the regulation of cell function. ECM proteins bind to cell surface receptors such as integrins, activating signaling pathways that regulate cellular morphology, adhesion, cell migration, cell proliferation, and apoptosis. This book covers all aspects of ECM composition and function, as well as alterations in the ECM that occur during tumorigenesis and other disease states. The editors are both giants in the field (Dr. Hynes discovered fibronectin), who are highly respected through the cell, molecular, and cancer biology communities.

Table of Contents

Preface	p. vii
Overview of the Matrisome- An Inventory of Extracellular Matrix Constituents and Functions	p. 1
Basement Membranes: Cell Scaffoldings and Signaling Platforms	p. 17
The Collagen Family	p. 45
Heparan Sulfate Proteoglycans	p. 65
The Thrombospondins	p. 99
Tenascins and the Importance of Adhesion Modulation	p. 129
Fibronectins, Their Fibrillogenesis, and In Vivo Functions	p. 149
Integrin Structure, Activation, and Interactions	p. 169
Cross Talk among TGF-ß Signaling Pathways, Integrins, and the Extracellular Matrix	p. 183
Molecular Architecture and Function of Matrix Adhesions	p. 201
Genetic Analyses of Integrin Signaling	p. 223
Integrins and Extracellular Matrix in Mechanotransduction	p. 245
Integrins in Cell Migration	p. 259
Extracellular Matrix Degradation and Remodeling in Development and Disease	p. 275
Extracellular Matrix in Development: Insights from Mechanisms Conserved between Invertebrates and Vertebrates	p. 299
Angiogenesis	p. 313
Extracellular Matrix: Functions in the Nervous System	p. 333
Cell-Extracellular Matrix Interactions in Normal and Diseased Skin	p. 357
Extracellular Matrix Proteins in Hemostasis and Thrombosis	p. 371
Index	p. 389
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