Fetal and Neonatal Brain Injury

by Edited by David K. Stevenson , William E. Benitz , Philip Sunshine , Susan R. Hintz , Maurice L. Druzin

• ISBN13: 9780521888592
• ISBN10: 052188859X
• Edition: 4th
• Format: Hardcover
• Copyright: 2009-07-27
• Publisher: Cambridge University Press

Summary

Improvements in the detection of fetal and neonatal brain injuries, advances in our understanding of the pathophysiology, cellular and molecular bases of encephalopathy, and new treatment options have all combined to produce significant changes in the management of neonatal brain disorders in the past few years. This new edition of Fetal and Neonatal Brain Injury brings the reader fully up to date with all advances in clinical management and outcome assessment. New material includes pregnancy-induced hypertension, HELLP syndrome and chronic hypertension, complications of multiple gestation, neurogenic disorders of the brain, neonatal stroke and much more. An expanded, highly illustrated chapter on structural and functional imaging of the fetal and neonatal brain is also included. An outstanding international team of highly experienced neonatologists and maternal-fetal medicine clinicians have produced a practical, authoritative clinical text that gives clear management advice to all clinicians involved in the treatment of these patients.

Table of Contents

Neonatal encephalopathy

Mechanisms of neurodegeneration and therapeutics in animal modes of neonatal hypoxic-ischemic encephalophathy

Cellular and molecular biology of hypoxic-encephalopathy

The pathogenesis of preterm brain injury

Prematurity and complications of labor and delivery

Risks and complications of multiple gestations

Intrauterine growth restriction

Maternal diseases that affect fetal development

Obstetrical conditions and practices that affect the fetus and newborn

Fetal and neonatal injury as a consequence of maternal substance abuse

Pregnancy induced hypertension, HELLP syndrome and chronic hypertension

Complications of labor and delivery

Fetal response to asphyxia

Antepartum evaluation of fetal well-being

Intrapartum evaluation of the fetus

Clinical manifestations of hypoxic-ischemic encephalopathy

The use of EEG in assessing acute and chronic brain damage in the newborn

Neuroimaging in the evaluation of pattern and timing of fetal and neonatal brain abnormalities

Light-based functional assessment of the brain

Placental pathology and the etiology of fetal and neonatal brain injury

Correlations of clinical, laboratory, imaging and placental findings as to the timing of asphyxial events

Congenital malformations of the brain

Neurogenetic disorders of the brain

Hemorrhagic lesions of the CNS

Neonatal stroke

Hypoglycemia in the neonate

Hyperbilirubinemia and kernicterus

Polycythemia and fetal-maternal bleeding

Hydrops fetalis

Bacterial sepsis in the neonate

Neonatal bacterial meningitis

Neurological sequelae of congenital perinatal infection

Perinatal human immunodeficiency virus infection

Inborn errors of metabolism with features of HIE

Acidosis and alkalosis

Meconium staining and the meconium aspiration syndrome

Persistent pulmonary hypertension of the newborn

Pediatric cardiac surgery: relevance to fetal and neonatal brain injury

Neonatal resuscitation: immediate management

Improving performance, reducing error, and minimizing risk in the delivery room

Extended management following resuscitation

Endogenous and exogenous neuroprotective mechanisms after hypoxic ischemic injury

Neonatal seizures

Nutritional support of the asphyxiated infant

Early childhood neurodevelopmental outcome of preterm infants

Assessment and management of infants with cerebral palsy

Long term impact of neonatal events on speech, language development and academic achievement

Neurocognitive outcomes of term infants with perinatal asphyxia

Appropriateness of intensive care application

Medicolegal issues in perinatal brain injury

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