From Local Invasion to Metastatic Cancer

by Leong, Stanley P. L.

• ISBN13: 9781603270861
• ISBN10: 1603270868
• eBook ISBN(s): 9781603270878
• Edition: 1st
• Format: Hardcover
• Copyright: 2009-05-08
• Publisher: Humana Pr Inc

Summary

In human solid tumors, nodal status is the most important prognostic indicator for patients' outcome. Recent developments in the sentinel lymph node concept have resulted in a procedure to define the first draining node as the primary gateway through which the cancer will spread. In From Local Invasion to Metastatic Cancer: Involvement of Distant Sites through the Lymphovascular System, a panel of international authorities takes an in-depth look at the role of the lymphovascular system in the spread of cancer. The authors summarize the findings of the Second International Symposium on Cancer Metastasis: Basis for Rational Therapy summit. Specifically, the book presents important developments in the biology and clinical understanding of cancer metastasis, describes the relationship between tumor microenvironment and proliferation, and defines the process of lymphangiogenesis and angiogenesis with special reference to cancer metastasis. From Local Invasion to Metastatic Cancer: Involvement of Distant Sites through the Lymphovascular System provides molecular oncologists, radiologists, and clinicians the necessary information to study and develop new strategies to curb the process of metastasis.

Table of Contents

IntroductionStanley

Tumor Microenvironment and Proliferation

Dynamic Reciprocity Between Tumor Cells and the Microenvironment

Inflammation as a Regulator of Epithelial Cancer Development

Targeting Molecular Signals in the Tumor Cell Microenvironment

Convergence of Embryonic and Tumorigenic Pathways: Role in TumorProgression

Lymphangiogenesis and Angiogenesis

Heme-Lymph Vasculo/Angiogenesis, Angiotumorigenesis, and Tumor Angiogenesis: A Lymphatic System Perspective

Model Systems to Study Lymphangiogenesis and Angiogenesis: Lessons for Tumor Biology

Vascular Permeability Factor, Lymphangiogenesis/Angiogenesis, and Cancer Biology

Molecular Events and Clinical Correlations in Tumor and Other Lymphangiogenesis

Tumor Lymphangiogenesis: What We Know and Don't Know

Diagnostic Imaging of Cancer

Molecular Imaging of Cancer - Receptors, Angiogenesis and Gene Expression

MRI and Ultrasound Imaging of Lymph Node

Molecular Imaging of the Sentinel Lymph Node

Lymphatic Dysfunction and Scintigraphy in Cancer Patients

Molecular Imaging of Neuroendocrine Cancer by fusion SPECT/CT

Concepts and Tools of Imaging Cancer

Therapeutic Targeting of the Lymphovascular System

Therapeutic Targeting of the Lymphovascular System

Targeted Introduction of Substances into the Lymph Nodes for Endolymphatic Therapy

Targeting Lymphovascular Endothelium with Anti-VEGFR-3 Monoclonal Antibodies

Radioimmunotherapy for Cancer

Animal Models to Study Lymphatic and Vascular Metastasis

Molecular Mechanisms of Metastasis

Early Development of Micrometastasis in Tumor-Draining Regional Lymph Nodes: Can They Be Predicted

Micrometastasis in Patients with Solid Epithelial Tumors

Imaging Tumor Metastasis and Dormancy in Experimental Models

Chemokine Receptors and Organ-Specific Metastasis

Tumor and Lymph Node Lymphangiogenesis: Impact on Metastasis

Role of the Tumor Microenvironment on Tumor Cell Survival and Metastasis

Treg, Chemokines and other Small Molecules: Role in Metastasis and its Prevention

Breast Cancer Metastasis to the Brain

Chemokines, Lymphatics and Metastasis

Molecular Targeted Therapy Against Growth Factor Receptors, Signaling Pathways and Angiogenesis As Therapeutic Targets

Molecular Targeting of Lymphangiogenesis and Tumor Metastasis

Beyond VEGF: Angiopoietins and Ephrins as Therapeutic Targets

VEGF Trap in Trials Today, and VelociGene with Veloc Immune for the Angiogenesis Targets of Tomorrow

Targeting EGFR/Angiogenesis

Targeting Signaling Pathways in Cancer Therapy

Impact of Nodal Status and Tumor Burden in Sentinel Nodes on the Clinical Outcome

Micrometastasis of Melanoma to SLNs

Micrometastasis of Breast Cancer to SLNs

Micrometastasis of Head and Neck Cancer to SLNs

Micrometastasis of Genitounrinary Cancer to SLNs

Micrometastasis of Colorectal Cancer to SLNs

Micrometastasis of Upper GI Cancer to SLNs

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