Fundamentals of Biochemistry: Life at the Molecular Level, 3rd Edition

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  • Edition: 3rd
  • Format: Hardcover
  • Copyright: 2008-01-01
  • Publisher: Wiley
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Voet, Voet, and Pratt's Fundamentals of Biochemistry, challenges students to better understand the chemistry behind the biological structure and reactions occurring in living systems. The Third Edition continues this tradition, and additionally incorporates coverage of recent research and an expanded focus on preparing and supporting students throughout the course. With the addition of new conceptual assessment content to WileyPLUS, students have the opportunity to assess their conceptual understanding of key introductory biochemistry concepts and retrain themselves on their misconceptions.

Author Biography

Donald Voet received a B.S. in Chemistry from the California Institute of Technology, a Ph.D. in Chemistry from Harvard University with William Lipscomb, and did postdoctoral research in the Biology Department at MIT with Alexander Rich. Upon completion of his postdoctoral research, Don took up a faculty position in the Chemistry Department at the University of Pennsylvania where, for the past 38 years, he has taught a variety of Biochemistry courses as well as general Chemistry. His major area of research is the X-ray crystallography of molecules of biological interest. He has been a visiting scholar at Oxford University, The University of California at San Diego, and the Weizmann Institute of Science in Israel. Together with Judith G. Voet, he is Co-Editor-in-Chief of the journal Biochemistry and Molecular Biology Education. He is a member of the Education Committee of the International Union of Biochemistry and Molecular Biology. His hobbies include backpacking, scuba diving, skiing, travel, photography, and writing Biochemistry textbooks.

Judith ("Judy") Voet received her B.S. in Chemistry from Antioch College and her Ph.D. in Biochemistry from Brandeis University with Robert H. Abeles. She has done postdoctoral research at the University of Pennsylvania, Haverford College, and the Fox Chase Cancer Center. Her main area of research involves enzyme reaction mechanisms and inhibition. She taught Biochemistry at the University of Delaware before moving to Swarthmore College. She taught there for 26 years, reaching the position of James H. Hammons Professor of Chemistry and Biochemistry before going on "permanent sabbatical leave." She has been a visiting scholar at Oxford University, University of California, San Diego, University of Pennsylvania, and the Weizmann Institute of Science, Israel. She is Co-Editor-in-Chief of the journal Biochemistry and Molecular Biology Education. She has been a member of the Education and Professional Development Committee of the American Society for Biochemistry and Molecular Biology as well as the Education Committee of the International Union of Biochemistry and Molecular Biology. Her hobbies include hiking, backpacking, scuba diving, and tap dancing.

Charlotte Pratt received her B.S. in Biology from the University of Notre Dame and her Ph.D. in Biochemistry from Duke University under the direction of Salvatore Pizzo. Although she originally intended to be a marine biologist, she discovered that Biochemistry offered the most compelling answers to many questions about biological structure-function relationships and the molecular basis for human health and disease. She conducted postdoctoral researching the Center for Thrombosis and Hemostasis at the University of North Carolina at Chapel Hill. She has taught at the University of Washington and currently teaches at Seattle Pacific University. In addition to working as an editor of several Biochemistry textbooks, she has co-authored Essential Biochemistry and previous editions of Fundamentals of Biochemistry.

Table of Contents

Introduction to the Chemistry of Life
The Origin of Life
Biological Molecules Arose from Inorganic Materials
Complex Self-replicating Systems Evolved from Simple Molecules
Cellular Architecture
Cells Evolved to Carry Out Metabolic Reactions
There Are Two Types of Cells: Prokaryotes and Eukaryotes
Molecular Data Reveal Three Evolutionary Domains of Organisms
Organisms Continue to Evolve
The First Law of Thermodynamics States that Energy Is Conserved
The Second Law of Thermodynamics States that Entropy Tends to Increase
The Free Energy Change Determines the Spontaneity of a Process
Free Energy Changes Can Be Calculated from Equilibrium Concentrations
Life Obeys the Laws of Thermodynamics
Box 1-1 Pathways of Discovery
Lynn Margulis and the Theory of Endosymbiosis
Box 1-2 Perspectives in Biochemistry
Biochemical Conventions
Physical Properties of Water
Water Is a Polar Molecule
Hydrophilic Substances Dissolve in Water
The Hydrophobic Effect Causes Nonpolar Substances to Aggregate in Water
Water Moves by Osmosis and Solutes Move by Diffusion
Chemical Properties of Water
Water Ionizes to Form H + and OH a??
Acids and Bases Alter the pH
Buffers Resist Changes in pH
Box 2-1 Biochemistry in Health and Disease
The Blood Buffering System
Nucleotides, Nucleic Acids, and Genetic Information
Introduction to Nucleic Acid Structure
Nucleic Acids Are Polymers of Nucleotides
The DNA Forms a Double Helix
RNA Is a Single-Stranded Nucleic Acid
Overview of Nucleic Acid Function
DNA Carries Genetic Information
Genes Direct Protein Synthesis
Nucleic Acid Sequencing
Restriction Endonucleases Cleave DNA at Specific Sequences
Electrophoresis Separates Nucleic Acids According to Size
DNA Is Sequenced by the Chain-Terminator Method A#1
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