Gene Therapy for Autoimmune and Inflammatory Diseases

by Chernajovsky, Yuti; Robbins, Paul D.

• ISBN13: 9783034601641
• ISBN10: 3034601646
• Edition: 1st
• Format: Hardcover
• Copyright: 2010-07-25
• Publisher: Birkhauser

Summary

This book addresses the latest advances in viral and non-viral vectors, novel targets and methods for the treatment of autoimmune and inflammatory disease with a main focus in pre-clinical testing with up to date clinical trials. The first section of the book deals with current research approaches for treating rheumatoid arthritis, osteoarthritis, diabetes, Crohn's disease, multiple sclerosis, Sjögrens syndrome, cystic fibrosis, myositis and lupus. The second section is devoted to cell delivery and vector development including plasmids, regulated promoters, adenovirus gutted vectors and adeno-associated vectors. All chapters are summarised by leaders in these fields. A must read for post graduate students, clinical and non-clinical researchers in the disciplines of immunology, molecular medicine, pharmacology, gene and cell-mediated therapy.

Table of Contents

List of Contributors	p. vii
Preface	p. xi
Gene therapy for arthritis	p. 1
Gene therapy for the treatment of inflammatory bowel disease	p. 19
Gene therapy for diabetes	p. 39
Gene therapy for cystic fibrosis lung disease	p. 47
Gene therapy of multiple sclerosis	p. 65
Gene therapy for myositis	p. 79
Gene therapy for osteoarthritis	p. 91
Gene therapy: Sjögren's syndrome	p. 113
Disease mechanisms, genetic susceptibility and therapeutic approaches in lupus disease	p. 127
Regulated promoters	p. 147
Development of AAV vectors for the therapy of autoimmune and inflammatory diseases	p. 161
Delivery and application of plasmid DNA in arthritis gene therapy	p. 181
Helper-dependent adenoviral vectors	p. 193
Cells as carriers of gene therapy	p. 209
Perspectives for the future developments of gene therapy for autoimmune and inflammatory therapy	p. 223
Index	p. 233
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