Gene Therapy and Tissue Engineering in Orthopaedic and Sports Medicine

by Huard, Johnny; Fu, Freddie H.

• ISBN13: 9780817640712
• ISBN10: 0817640711
• eBook ISBN(s): 9781461221265
• Format: Hardcover
• Copyright: 2000-09-01
• Publisher: Birkhauser

Summary

With the development of improved methods of transferring genes into cells, new treatment options are becoming available in orthopaedics and sports medicine to aid in the healing capacity of musculoskeletal tissues. In this book, current techniques in gene therapy and tissue engineering are described in addition to their potential applications in the management of orthopaedic trauma and sports-related injuries such as muscle injury and ligament, meniscus, or cartilage damage. The book bridges the gap between the clinicians aiming to improve recovery following such injuries, and researchers interested in tissue engineering and gene therapy. This book will be read by physicians and researchers in orthopaedic surgery, sports medicine, and cell and molecular biology.

Table of Contents

Preface	ix
Acknowledgments	xi
Contributors	xiii
Part I: Background
Gene Therapy in Orthopaedics	3	(12)
Christian Lattermann
Freddie H. Fu
The Use of Different Viral Vectors and Strategies for Gene Transfer to the Musculoskeletal System	15	(28)
Johnny Huard
Part II: Gene Therapy Applications for the Musculoskeletal System
Regional Gene Therapy for Hard Tissues	43	(14)
Jay R. Lieberman
Potential Applications of Gene Therapy to the Treatment of Spinal Disorders	57	(17)
Kotaro Nishida
James D. Kang
Scott D. Boden
Lars G. Gilbertson
Jun-Kyo Suh
Paul D. Robbins
Christopher H. Evans
The Development of Approaches Based on Gene Therapy to Improve Muscle Healing Following Injury	74	(15)
Jacques Menetrey
Channarong Kasemkijwattana
Charles S. Day
Patrick Bosch
Morey S. Moreland
Freddie H. Fu
Johnny Huard
Nonviral Gene Therapy: Application in the Repair of Osteochondral Articular Defects	89	(17)
Randal S. Goomer
David Amiel
The Potential of Gene Therapy for Osteogenesis Imperfecta	106	(20)
Christopher Niyibizi
Patrick N. Smith
Joel Greenberger
The Role of Nitric Oxide as a Candidate Molecule for Gene Therapy in Sports Injuries	126	(17)
Scott A. Rodeo
Kazutaka Izawa
Part III: Tissue Engineering in Orthopaedics and Sports Medicine
Stem Cells and	143	(31)
Tissue Engineering
Henry E. Young
Tissue Engineering of Ligament Healing	174	(22)
Savio L.-Y. Woo
Nobuyoshi Watanabe
Kevin A. Hildebrand
Muscle-Based Tissue Engineering for Orthopaedic Applications	196	(17)
Douglas S. Musgrave
Charles S. Day
Patrick Bosch
Jacques Menetrey
Channarong Kasemkijwattana
Morey S. Moreland
Freddie H. Fu
Johnny Huard
Application of Tissue Engineering to Cartilage Repair	213	(20)
Jun-Kyo Suh
Freddie H. Fu
Part IV: Hurdles and Development of New Vectors for Gene Therapy and Tissue Engineering
Immune Reaction Following Cell and Gene Therapy	233	(12)
Jacques P. Tremblay
Vectors for Gene Transfer to Joints	245	(15)
Paul D. Robbins
Steven C. Ghivizzani
Joseph C. Glorioso
Christopher H. Evans
Adeno-Associated Virus (AAV) for Musculoskeletal Gene Transfer	260	(15)
Xiao Xiao
Ryan Pruchnic
Juan Li
Johnny Huard
Index	275