Growth Disorders Pathophysiology and Treatment

by Kelnar, Christopher J. H.; Savage, Martin O.; Stirling, Heather F.; Saenger, Paul

• ISBN13: 9780412737008
• ISBN10: 0412737000
• Edition: 1st
• Format: Hardcover
• Copyright: 1999-01-28
• Publisher: Hodder Education Publishers

Summary

This book, written by internationally recognized experts in their respective disciplines, will provide comprehensive and up-to-date information about growth disorders for the practicing clinician who deals with children and adolescents. It will be a valuable reference source as well as apractical management guide for general and specialist paediatricians and endocrinologists. It would also be of interest to community and primary care health workers, as well as child and family psychiatrists.

Table of Contents

List of contributors
Foreword
Preface
Historical background and worldwide perspectives	p. 1
Physiology of Linear Growth	p. 15
Cellular growth	p. 17
Bone and cartilage growth	p. 27
Genetic control of growth	p. 39
Rhythms of linear growth	p. 63
Nutrition and growth	p. 79
Endocrinology of growth	p. 97
Central regulation of growth hormone secretion	p. 99
Peripheral hormone action	p. 126
Normal fetal growth	p. 143
Growth in infancy and childhood	p. 159
Growth at adolescence	p. 179
Growth Assessment	p. 195
Abnormal growth: definition, pathogenesis and practical assessment	p. 197
Practical auxology: techniques of measurement and assessment of skeletal maturity	p. 225
Endocrine assessment of growth	p. 237
Radiologic and imaging assessment of the skeletal dysplasias	p. 251
Psychological assessment of children with growth deficiency	p. 265
Chronic Paediatric Disorders and Management of Associated Growth Disturbance	p. 279
Pregnancy and the growth restricted fetus	p. 281
Genetic and dysmorphic syndromes of short stature	p. 297
Genetic and dysmorphic syndromes with tall stature	p. 323
Skeletal dysplasias	p. 337
Respiratory disease and growth	p. 357
Gastrointestinal disorders	p. 371
Growth failure in chronic renal disorders	p. 387
Disorders of calcium	p. 409
Diabetes	p. 421
Growth and the cardiovascular system	p. 435
Neurological disorders	p. 447
Haemoglobinopathies	p. 471
Psychological disorders	p. 483
Growth failure in tropical and developing countries	p. 497
Endocrine Causes of Abnormal Growth	p. 509
Abnormalities of growth hormone	p. 511
Secretion	p. 511
Action	p. 549
Growth and thyroid disorders	p. 565
Adrenal and gonadal disorders	p. 575
Treatment of Growth Disorders	p. 587
Growth hormone deficiency	p. 589
Idiopathic short stature	p. 609
Turner and Noonan syndromes: disease-specific growth and growth-promoting therapies	p. 623
Disorders of growth and development in the child treated for cancer	p. 641
Intrauterine growth retardation	p. 661
Constitutional delay of growth and puberty	p. 673
Treatment of growth hormone resistance	p. 691
Growth hormone-releasing hormone and other growth hormone secretagogues	p. 701
Limb-lengthening techniques	p. 721
Metabolic side effects and adverse effects of growth hormone therapy	p. 745
Precocious puberty	p. 765
Constitutional advanced growth and gigantism	p. 775
Surgical management of tall stature	p. 791
Index	p. 801
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