9780521873437

Handbook of Iron Overload Disorders

by
  • ISBN13:

    9780521873437

  • ISBN10:

    0521873436

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2010-09-06
  • Publisher: Cambridge University Press

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Summary

A practical, clinically-oriented handbook of iron overload disorders giving a compact guide to normal iron metabolism, iron-related pathobiology, and the diagnosis and management of heritable and acquired iron overload disorders. Many of these disorders were discovered and characterized only in the last decade, and are unmentioned or inadequately described in most texts. Written by clinicians for clinicians, this handbook summarizes information on diverse iron overload conditions, including their history, signs, symptoms, physical examination findings, genetics, genotype-phenotype correlations, pathophysiology, differential diagnosis and treatment. Most physicians, regardless of specialty, encounter patients with systemic or organ-specific iron overload conditions. This book contains essential information for practising adult and pediatric medical specialists in the fields of hematology, gastroenterology, hepatology, rheumatology, endocrinology, diabetology, neurology, oncology, dermatology and internal medicine. Pathologists, pharmacologists, geneticists, genetic counselors and epidemiologists will also find substantial, up-to-date sections in this handbook that are pertinent to their respective fields of interest.

Table of Contents

Foreword
Preface
History of iron overload disorders
Normal iron absorption and metabolism
Iron toxicity
Tests for hemochromatosis and iron overload
Complications of hemochromatosis and iron overload
Insulin resistance and iron overload
Infections and immunity
Classical and atypical hfe hemochromatosis
Heterozygosity for hfe c282y
Porphyria cutanea tarda
Mitochondrial mutations as modifiers of hemochromatosis
Hemochromatosis associated with ferroportin gene (slc40a1) mutations
Hemochromatosis associated with hemojuvelin gene (hjv) mutations
Hemochromatosis associated with hepcidin gene (hamp) mutations
Hemochromatosis associated with transferrin receptor-2 gene (tfr2) mutations
Iron overload associated with ire mutation of ferritin heavy-chain gene (fth1)
Hereditary hyperferritinemia-cataract syndrome: ire mutations of ferritin light chain gene (ftl)
Iron overload in native Africans and African Americans
Hereditary atransferrinemia
Divalent metal transporter-1 (dmt1) iron overload
Iron overload associated with thalassemia syndromes
Iron overload associated with hemoglobinopathies
Iron overload associated with pyruvate kinase deficiency
Iron overload associated with congenital dyserythropoietic anemias
Hereditary sideroblastic anemias
Pearson marrow-pancreas syndrome
Acquired sideroblastic anemias
Hereditary aceruloplasminemia
Friedreich ataxia and cardiomyopathy
Pantothenate kinase (pank2)-associated neurodegeneration
Neuroferritinopathies
Gracile syndrome
Neonatal hemochromatosis
Iron overload due to excessive supplementation
Localized iron overload
Management of iron overload
Population screening for hemochromatosis
Ethical, legal, and social issues
Directions for future research
Index
Table of Contents provided by Publisher. All Rights Reserved.

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