Harper's Illustrated Biochemistry

by Murray, Robert; Granner, Daryl K.; Mayes, Peter A.; Rodwell, Victor W.

• ISBN13: 9780071389013
• ISBN10: 0071389016
• eBook ISBN(s): 9780071389013
• Additional ISBN(s): 9780071461979, 9780838536841
• Format: Paperback
• Copyright: 2003-03-18
• Publisher: McGraw-Hill Medical
• More Book Details
• Purchase Benefits

Summary

Extensively revised and updated, this authoritative biochemistry text is known worldwide for its comprehensive and up-to-date coverage. Extensively illustrated and user-friendly, the text offers examples pf how knowledge of biochemistry is essential for understanding the molecular basis of health and disease. The 26th edition also features expanded content on results of the Human Genome Project. Perfect as both text and USMLE review.

Table of Contents

Authors	p. vii
Preface	p. ix
Biochemistry & Medicine	p. 1
Water & pH	p. 5
Structures & Functions of Proteins & Enzymes	p. 14
Amino Acids & Peptides	p. 14
Proteins: Determination of Primary Structure	p. 21
Proteins: Higher Orders of Structure	p. 30
Proteins: Myoglobin & Hemoglobin	p. 40
Enzymes: Mechanism of Action	p. 49
Enzymes: Kinetics	p. 60
Enzymes: Regulation of Activities	p. 72
Bioenergetics & the Metabolism of Carbohydrates & Lipids	p. 80
Bioenergetics: The Role of ATP	p. 80
Biologic Oxidation	p. 86
The Respiratory Chain & Oxidative Phosphorylation	p. 92
Carbohydrates of Physiologic Significance	p. 102
Lipids of Physiologic Significance	p. 111
Overview of Metabolism	p. 122
The Citric Acid Cycle: The Catabolism of Acetyl-CoA	p. 130
Glycolysis & the Oxidation of Pyruvate	p. 136
Metabolism of Glycogen	p. 145
Gluconeogenesis & Control of the Blood Glucose	p. 153
The Pentose Phosphate Pathway & Other Pathways of Hexose Metabolism	p. 163
Biosynthesis of Fatty Acids	p. 173
Oxidation of Fatty Acids: Ketogenesis	p. 180
Metabolism of Unsaturated Fatty Acids & Eicosanoids	p. 190
Metabolism of Acylglycerols & Sphingolipids	p. 197
Lipid Transport & Storage	p. 205
Cholesterol Synthesis, Transport, & Excretion	p. 219
Integration of Metabolism--the Provision of Metabolic Fuels	p. 231
Metabolism of Proteins & Amino Acids	p. 237
Biosynthesis of the Nutritionally Nonessential Amino Acids	p. 237
Catabolism of Proteins & of Amino Acid Nitrogen	p. 242
Catabolism of the Carbon Skeletons of Amino Acids	p. 249
Conversion of Amino Acids to Specialized Products	p. 264
Porphyrins & Bile Pigments	p. 270
Structure, Function, & Replication of Informational Macromolecules	p. 286
Nucleotides	p. 286
Metabolism of Purine & Pyrimidine Nucleotides	p. 293
Nucleic Acid Structure & Function	p. 303
DNA Organization, Replication, & Repair	p. 314
RNA Synthesis, Processing, & Modification	p. 341
Protein Synthesis & the Genetic Code	p. 358
Regulation of Gene Expression	p. 374
Molecular Genetics, Recombinant DNA, & Genomic Technology	p. 396
Biochemistry of Extracellular & Intracellular Communication	p. 415
Membranes: Structure & Function	p. 415
The Diversity of the Endocrine System	p. 434
Hormone Action & Signal Transduction	p. 456
Special Topics	p. 474
Nutrition, Digestion, & Absorption	p. 474
Vitamins & Minerals	p. 481
Intracellular Traffic & Sorting of Proteins	p. 498
Glycoproteins	p. 514
The Extracellular Matrix	p. 535
Muscle & the Cytoskeleton	p. 556
Plasma Proteins & Immunoglobulins	p. 580
Hemostasis & Thrombosis	p. 598
Red & White Blood Cells	p. 609
Metabolism of Xenobiotics	p. 626
The Human Genome Project	p. 633
Appendix	p. 639
Index	p. 643
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