The Human Frontal Lobes, Second Edition Functions and Disorders

by Miller, Bruce L.; Cummings, Jeffrey L.

• ISBN13: 9781593853297
• ISBN10: 1593853297
• Edition: 2nd
• Format: Hardcover
• Copyright: 2006-11-30
• Publisher: The Guilford Press

Summary

Now in a revised and expanded second edition, this authoritative work synthesizes the rapidly growing knowledge base on the human frontal lobes and their central role in behavior, cognition, health, and disease. Leading contributors address neuroanatomy, neurochemistry, and normal neuropsychological functioning, and describe the nature and consequences of frontal lobe dysfunction in specific neurological and psychiatric conditions. Second edition features include a new section on structural and functional neuroimaging and substantially expanded coverage of frontotemporal dementia and related disorders. Other new topics include self-consciousness, competence, and personality; new testing approaches; bipolar disorder; and adult-onset genetic disorders of the frontal lobes. The book is illustrated with nearly 100 figures.

Author Biography

Bruce L. Miller, MD, is Professor of Neurology at the University of California at San Francisco (UCSF), where he holds the A.W. & Mary Margaret Clausen Distinguished Chair. He is also the clinical director of the aging and dementia program at UCSF, where he heads the State of California Research and Clinical Center and a new National Alzheimer’s Disease Research Center. For nearly two decades, Dr. Miller has been the scientific director of the John Douglas French Foundation for Alzheimer’s Disease. He has been listed in The Best Doctors in America since 1996. Dr. Miller directs a National Institutes of Health-funded program on frontotemporal dementia (FTD) called “FTD: Genes, Images, and Emotions.” He has published more than 250 articles.
 
Jeffrey L. Cummings, MD, is Director of the Alzheimer’s Disease Research Center and the Deane F. Johnson Center for Neurotherapeutics at the University of California at Los Angeles (UCLA). He is the Augustus S. Rose Professor of Neurology and Professor of Psychiatry and Biobehavioral Sciences in the David Geffen School of Medicine at UCLA. Dr. Cummings is past president of the American Neuropsychiatric Society and the Behavioral Neurology Society. He is the recipient of several prestigious awards, including the Henderson Lectureship of the American Neurological Society. Dr. Cummings has lectured, pursued research, and published on the topics of neuropsychiatry, behavioral neurology, neurotherapeutics, and drug development. He has contributed to the understanding of the role of the frontal-subcortical circuits in the behavior of normal individuals and of persons with brain disorders, and is the author of the Neuropsychiatric Inventory, a tool used to assess behavioral changes in patients with neurological diseases.

Table of Contents

PART I. OVERVIEW OF THE FRONTAL LOBES
The Human Frontal Lobes: An Introduction	3	(9)
Bruce L. Miller
Conceptual and Clinical Aspects of the Frontal Lobes	12	(13)
Jeffrey L. Cummings
Bruce L. Miller
PART II. ANATOMY
Frontal-Subcortical Circuits	25	(19)
Tiffany W. Chow
Jeffrey L. Cummings
The Dorsolateral and Cingulate Cortex	44	(15)
Daniel I. Kaufer
The Orbitofrontal Cortex and the Insula	59	(9)
Jennifer Ogar
Maria Luisa Gorno-Tempini
Structural and Functional Asymmetries of the Human Frontal Lobes	68	(24)
Daniel H. Geschwind
Marco Iacoboni
Gross Morphology and Architectonics	92	(15)
Danielle Andrea Carlin
Evolution of the Frontal Lobes	107	(14)
Harry J. Jerison
PART III. NEUROCHEMISTRY
Serotonin and the Frontal Lobes	121	(14)
Philippe H. Robert
Michel Benoit
Herve Caci
Oiling the Gears of the Mind: Roles for Acetylcholine in the Modulation of Attention	135	(10)
Serena Amici
Adam L. Boxer
The Mesocortical Dopaminergic System	145	(20)
Antonello Bonci
Susan Jones
PART IV. FUNCTIONAL AND STRUCTURAL IMAGING APPROACHES
Structural Imaging of the Frontal Lobes	165	(22)
Howard Rosen
David Dean
Unifying Prefrontal Cortex Function: Executive Control, Neural Networks, and Top-Down Modulation	187	(20)
Adam Gazzaley
Mark D'Esposito
Insight into Frontal Lobe Function from Functional Neuroimaging Studies of Episodic Memory	207	(20)
W. Dale Stevens
Cheryl L. Grady
The Frontal Lobes and Autobiographical Memory	227	(22)
Margaret C. McKinnon
Eva Svoboda
Brian Levine
Planning and the Brain	249	(13)
Jordan Grafman
Principles of Motor Control by the Frontal Lobes as Revealed by the Study of Voluntary Eye Movements	262	(17)
Adam L. Boxer
PART V. NEUROPSYCHOLOGICAL FUNCTIONS
Bedside Frontal Lobe Testing	279	(13)
Joel H. Kramer
Lovingly Quitania
New Approaches to Prefrontal Lobe Testing	292	(14)
Donald T. Stuss
Language and Frontal Cortex	306	(11)
Argye E. Hillis
Self-Representation and the Frontal Lobes	317	(18)
William W. Seeley
Virginia E. Sturm
Frontal Dysfunction and Capacity to Consent to Treatment or Research: Conceptual Considerations and Empirical Evidence	335	(10)
Laura B. Dunn
Barton W. Palmer
Jason H. T. Karlawish
Social Cognition in Frontal Injury	345	(20)
Katherine P. Rankin
PART VI. NEUROLOGICAL DISEASES
A. Frontotemporal Dementia and Related Disorders
Clinical Aspects of Frontotemporal Dementia	365	(17)
Pei-Ning Wang
Bruce L. Miller
Genetics and Neuropathology of Frontotemporal Dementia	382	(26)
Nigel J. Cairns
Virginia M.-Y. Lee
John Q. Trojanowski
Imaging in Frontotemporal Dementia	408	(14)
Murray Grossman
Progressive Supranuclear Palsy, Corticobasal Degeneration, and the Frontal Cortex	422	(7)
Irene van Balken
Irene Litvan
Frontal Variant of Alzheimer's Disease	429	(18)
Julene K. Johnson
Arne Brun
Elizabeth Head
B. Other Neurological Disorders
Vascular Disease of the Frontal Lobes	447	(25)
Ae Young Lee
Helena Chui
Parkinson's Disease with and without Dementia and Lewy Body Dementia	472	(33)
Bruno Dubois
Bernard Pillon
Ian G. McKeith
Neurosurgical Intervention for Psychiatric Illness: Past, Present, and Future	505	(13)
Anthony P. Weiss
Scott L. Rauch
Bruce H. Price
Infectious, Inflammatory, and Demyelinating Disorders	518	(22)
Douglas W. Scharre
Traumatic Brain Injury	540	(12)
Judith Aharon-Peretz
Rachel Tomer
Adult-Onset Genetic Disorders Involving the Frontal Lobes	552	(24)
Michael D. Geschwind
Grace Yoon
Jill Goldman
Frontal Lobe Development in Childhood	576	(21)
Carole Samango-Sprouse
PART VII. PSYCHIATRIC DISEASES
Frontal Lobe Functioning in Schizophrenia: Evidence from Neuropsychology, Cognitive Neuroscience, and Psychophysiology	597	(17)
Susan A. Legendre Ropacki
William Perry
Bipolar Disorder and the Frontal Lobes	614	(7)
Mary G. DeMay
Danijela Pavlic
Bruce L. Miller
Obsessive-Compulsive Disorder and the Frontal Lobes	621	(15)
Denys Fontaine
Vianney Mattei
Philippe H. Robert
Depression and the Frontal Lobes	636	(13)
Ira M. Lesser
Julia A. Chung
Index	649