Immune Dysfunction and Immunotherapy in Heart Disease

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  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2007-09-24
  • Publisher: Wiley-Blackwell
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Current heart failure therapeutics affects symptoms without appreciably reducing the mortality rate of 50% in five years -- suggesting a failure in treating the underlying mechanism. This book proposes a new mechanism for heart failure; immune mediated cardiac remodelling for cardiac dysfunction.The outstanding editor team of two internationally recognized immunologists -- Ronald Watson, who has studied heart disease in immune dysfunction for a decade and has a patent for an immunotherapy of heart disease by immune regulation, and Douglas Larson, whose experience in cardiac transplantation immunology has provided the foundation for research into novel therapeutics for heart failure and hypertension - makes Immune Dysfunction and Immunotherapy in Heart Disease the definitive reference to the state of the science in this area.The four parts of the book address: Immune Dysfunction Leading to Heart Disease: Induction by Physiological Changes Immune Dysfunction Promoting CVD: Induction by Transplantation Drugs Immune Dysfunction Leading to Heart Dysfunction: Induction or Prevention by Cardiotherapeutic Drugs Immune Dysfunction Leading to Heart Disease: Induction by PathogensBoth researchers and practitioners will find this authoritative volume an excellent source of information on novel immune targeted therapeutics.

Author Biography

Dr. Larson and Dr. Watson have worked together researching the role of immune and cytokine dysfunction in heart disease for 8 years. They have been and currently are funded to do such research by grants from the U.S. National Institute of Heart, Lung and Blood, the American Heart Foundation, companies and private foundations. Dr. Watson has edited 62 scientific books, including several dealing with heart disease and conditions such as aging and AIDS that promote immune dysfunction as well as heart disease. Dr. Larson directs the Center's organ perfusion program as well as its Master degree in pharmacology and toxicology for perfusion students.


Ronald Ross Watson Ph.D.

Professor Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health and the Sarver Heart Center in the School of Medicine, University of Arizona, P. O. Box 245155, 1501 N. Campbell Avenue, Tucson, AZ 85749.

(520) 626 2850, Fax (520) 626 6093 rwatson@u.arizona.edu


Douglas F. Larson Ph.D.

Professor Surgery and the Sarver Heart Center in the School of Medicine, University of Arizona, P. O. Box 245066, 1501 N. Campbell Avenue, Tucson, AZ 85749. (520) 626 6494 dflarson@email.arizona.edu

Table of Contents

Contributorsp. vii
Prefacep. xi
About the Editorsp. xiii
Immune dysfunction leading to heart disease: induction by physiological changesp. 1
Immunosuppression by ultraviolet light-B radiation: a mediator of cardiac remodelingp. 3
Immune mechanisms in pediatric cardiovascular diseasep. 6
Heart failure-role of autoimmunityp. 17
Immune basis of hypertension in humansp. 28
Immune dysregulation: potential mediator of metabolic syndrome-induced cardiac remodelingp. 34
T helper 2 cell cytokines in remodeling of aortic wallp. 39
Effects of TNF-[alpha] on cardiac functionp. 48
Immunosuppression in promotion of cardiac allograft vasculopathyp. 57
Immunotherapy for left ventricular dysfunction after heart transplantationp. 80
Immune dysfunction promoting CVD: induction by transplantation drugsp. 95
Immunomodulating therapy in chronic heart failurep. 97
Statins in atherosclerosis: role of immune regulationp. 109
ACE inhibitors as immunomodulators: treatment of cardiovascular diseasep. 116
Treatment of heart failure by anticytokine therapiesp. 128
Immune dysfunction leading to heart dysfunction: induction or prevention by cardiotherapeutic drugsp. 133
Pathogenesis of cardiovascular complications in the acquired immunodeficiency syndromep. 135
Cytokines and T cell-mediated responses in autoimmune myocarditisp. 152
Drugs of abuse: accentuation of immunomodulation of viral myocarditisp. 157
Immune dysfunction leading to heart disease: induction by pathogensp. 173
Osteopontin: the link between the immune system and cardiac remodelingp. 175
Inflammatory immune activation in heart failure patients: therapeutic implicationsp. 182
Role of innate immune dysregulation in diabetic heart failurep. 186
Tolerance in heart transplantation: current and future rolep. 195
Neutralization of Th2 cytokines in therapy of cardiovascular pathologyp. 207
Anti-inflammatory immune therapy in heart diseasep. 217
Cholesterol, interleukin-6 inflammation, and atherosclerosis-role of statins, bisphosphonates, and plant polyphenols in atherosclerosis and other diseases of agingp. 227
Autoimmune myocarditis: treatment with anti-T-cell antibodiesp. 256
Immunosuppressive therapy to counter cardiac allograft vasculopathyp. 263
Role of oral pathogens in the pathogenesis of coronary heart diseasep. 271
Myocardial regenerative potential by stem cell transplantp. 280
Bioflavanoids and dietary anti-inflammatory actions: role in cardiovascular diseasesp. 288
Indexp. 301
Table of Contents provided by Ingram. All Rights Reserved.

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