Inflammation in the Pathogenesis of Chronic Diseases

by Harris, Randall E.

• ISBN13: 9781402056871
• ISBN10: 1402056877
• Edition: 1st
• Format: Hardcover
• Copyright: 2007-05-04
• Publisher: Springer Verlag

Summary

In "Inflammation in the Pathogenesis of Chronic Diseases: The COX-2 Controversy", a worldwide panel of leading experts discusses the role of inflammation in the pathogenesis of major chronic diseases and the current controversy regarding risk versus benefit of selective cyclooxygenase-2 (COX-2) inhibitors. This volume is intended for scientists in medicine, epidemiology, pharmacology, molecular biology, and related fields. The authors provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine, including historical perspectives on the discovery and development of aspirin, ibuprofen, and compounds that selectively inhibit COX-2, and the potential for development of new compounds with better efficacy and safety in the 21st century. Specfic chapters illuminate the role of inflammatory mechanisms in the pathogenesis of arthritis, cardiovascular disease, cancer, neurodegenerative disease, diabetes mellitus, obesity, and other life-threatening and debilitating conditions. Experts in cardiovascular medicine explore the "COX-2 controversy" regarding adverse effects of some (not all) selective COX-2 inhibitors on the cardiovasculature. Recent findings suggest that cardiovascular risk associated with some COX-2 inhibitors may not be due to a class effect, but rather depends upon the molecular structure of specific compounds. Important findings are documented in cancer research showing that selective COX-2 inhibitors have powerful antineoplastic effects against major forms of cancer. A special section explores the current evidence supporting the role of COX-2 and inflammation in the development of Alzheimer's disease and other neurodegenerative conditions and the potential benefit of compounds that modulate COX-2 and other inflammatory cytokines. The final section addresses nutritional modulation of inflammation and the chemopreventive value of anti-inflammatory nutraceutical agents.

Table of Contents

Preface

Contributors

Historical Perspectives

Anti-inflammatory Drugs in the 21st Century

Inflammatory Mechanisms of Pathogenesis

Nitric oxide synthase and cyclooxygenase interactions in cartilage and meniscus: relationships to joint physiology, arthritis, and tissue repair

Obesity, inflammation, and vascular disease: The Role of the Adipose Tissue as an Endocrine Organ

COX-2 and THE Inflammogenesis of Cancer

Role of COX-2 in Inflammatory and Degenerative Brain Diseases

Inflammation and Cardiovascular Disease: the Coxib Controversy

Cardiovascular Effects of the Selective Cyclooxygenase-2 Inhibitors

COX-2 inhibitors and Cardiovascular

A Biological Rationale For The Cardiotoxic Effects Of Rofecoxib: Comparative Analysis with other COX-2 Selective Agents and NSAIDsR

COX-2 Blockade in Cancer Prevention and Therapy

Cancer Chemoprevention by COX-2 Blockade: Results of Case Control Studies

Strategies for Colon Cancer Prevention: Combination of Chemopreventive Agents

Inflammation and Neurodegenerative Disease

NSAIDs FOR THE Chemoprevention of Alzheimer's Disease

Inflammation in Parkinson's disease: causative or epiphenomenal?

Nutrition, Inflammation and Chronic Disease

Nutrition, Inflammation, And Cardiovascular Disease

Nutrition, Inflammation & Brain Aging

Index

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