An Introduction to Forensic Genetics

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  • Edition: 2nd
  • Format: Paperback
  • Copyright: 2011-02-01
  • Publisher: Wiley

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This is a completely revised edition of a comprehensive and popular introduction to the fast moving area of Forensic Genetics. The text begins with key concepts needed to fully appreciate the subject and moves on to examine the latest developments in the field. Now illustrated in full colour throughout, this accessible textbook includes numerous references to relevant casework. With information on the full process of DNA evidence from collection at the scene of a crime to presentation in a legal context this book provides a complete overview of the field.Key Features: Greater in-depth coverage of kinship problems now covered in two separate chapters: one dealing with relationships between living individuals and the other covering identification of human remains. New chapter on non-human forensic genetics, including identification of bacteria and viruses, animals and plants. Self assessment questions to aid student understanding throughout the text. Now with full colour illustrations throughout New companion website Accessible introduction to forensic genetics, from the collection of evidence to the presentation of evidence in a legal context.Included in the Forensic Science Society 'Essentials in Forensic Science' book series. This edition is to be included in the Forensic Science Society 'Essentials of Forensic Science' book series aimed at advanced level undergraduates and new practitioners to the field.

Table of Contents

Introduction to forensic geneticsForensic genetics
Forensic genetics
A brief history of forensic genetics
DNA structure and the genome
DNA structure
Organization of DNA into chromosomes
The structure of the human genome
Genetic diversity of modern humans
The genome and forensic genetics
Tandem repeats
Single nucleotide polymorphisms
Biological material-collection, characterization and storage
Sources of biological evidence
Collection and handling of material at the crime scene
Identification and characterization of biological evidence
Evidence collection
Sexual and physical assault
Storage of biological material
DNA extraction and quantification
General principles of DNA extraction
DNA extraction from challenging samples
Quantification of DNA
DNA IQ system
Polymerase chain reaction
The evolution of PCR-based profiling in forensic genetics
DNA replication: the basis of the PCR
The components of PCR
Taq DNA polymerase
The PCR process
PCR inhibition
Sensitivity and contamination
The PCR laboratory
The analysis of short tandem repeats
Structure of STR loci
The development of STR multiplexes
Detection of STR polymorphisms
Interpretation of STR profiles
Assessment of STR profiles
Stutter peaks
Split peaks (N)
Template DNA
Overloaded profiles
Low template DNA typing
Peak balance
Degraded DNA
PCR inhibition
Statistical interpretation of STR profiles
Population genetics
Deviation from the Hardy-Weinberg equilibrium
Statistical tests to determine deviation from the Hardy-Weinberg equilibrium
Estimating the frequencies of STR profiles
Corrections to allele frequency databases
Which population frequency database should be used?
Evaluation and presentation of DNA evidence
Hierarchies of propositions
Likelihood ratios
Two fallacies
Comparison of three approaches
Databases of DNA profiles
The UK National DNA Database
Legislation in England and Wales
International situation
Kinship testing
Parentage testing
Punnett square
Identification of human remains
Single nucleotide polymorphisms
SNPs-occurrence and structure
Detection of SNPs
SNP detection for forensic applications
Forensic applications of SNPs
SNPs compared with STR loci
Lineage markers
Applications of mtDNA profiling
Haplotypes and haplogroups
The Y chromosome
Forensic applications of Y chromosome polymorphisms
Non-human DNA typing
Non-human sample types
Species identification
Linkage to an individual using STR Loci
Linkage to an individual using mitochondrial loci
Microbial DNA testing
Concluding comments
Forensic parameters
Useful web links
Table of Contents provided by Publisher. All Rights Reserved.

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