The Kinetochore

by De Wulf, Peter; Earnshaw, William C., Ph.D.

• ISBN13: 9780387690735
• ISBN10: 0387690735
• Format: Hardcover
• Copyright: 2008-11-14
• Publisher: Springer Nature

Summary

Kinetochores orchestrate the faithful transmission of chromosomes from one generation to the next. Kinetochores were first depicted over 100 years ago, but kinetochore research has progressed by leaps and bounds since the first description of their constituent DNA and proteins in the 1980s. 'œThe Kinetochore: from Molecular Discoveries to Cancer Therapy' presents a thorough up-to-date analysis of kinetochore and centromere composition, formation, regulation, and activity, both in mitosis and meiosis, in humans and 'œmodel' eukaryotic species, and at natural and mutant neocentromeres. Recently initiated translational research on kinetochores is also discussed as kinetochores are being mined as a very rich target for the next generations of anti-cancer drugs.

Table of Contents

Centromeres and Kinetochores: An Historical Perspective	p. 1
The Basics of Chromosome Segregation	p. 21
The Centromere	p. 45
Neocentromeres	p. 77
Human Artificial Centromeres: De novo Assembly of Functional Centromeres on Human Artificial Chromosomes	p. 107
Kinetochore Composition, Formation, and Organization	p. 133
Evolution of Centromeres and Kinetochores: A Two-Part Fugue	p. 193
Mitotic Spindle Assembly Mechanisms	p. 231
Kinetochore-Microtubule Interactions	p. 269
Post-Translational Modifications that Regulate Kinetochore Activity	p. 293
The Role of the Kinetochore in Spindle Checkpoint Signaling	p. 345
Kinetochore Regulation of Anaphase and Cytokinesis	p. 371
Roles of Centromeres and Kinetochores in Meiosis	p. 395
The Kinetochore-Cancer Connection	p. 433
The Kinetochore as Target for Cancer Drug Development	p. 455
Index	p. 481
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