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9780387690735

The Kinetochore

by ;
  • ISBN13:

    9780387690735

  • ISBN10:

    0387690735

  • Format: Hardcover
  • Copyright: 2008-11-14
  • Publisher: Springer Nature

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Supplemental Materials

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Summary

Kinetochores orchestrate the faithful transmission of chromosomes from one generation to the next. Kinetochores were first depicted over 100 years ago, but kinetochore research has progressed by leaps and bounds since the first description of their constituent DNA and proteins in the 1980s. 'œThe Kinetochore: from Molecular Discoveries to Cancer Therapy' presents a thorough up-to-date analysis of kinetochore and centromere composition, formation, regulation, and activity, both in mitosis and meiosis, in humans and 'œmodel' eukaryotic species, and at natural and mutant neocentromeres. Recently initiated translational research on kinetochores is also discussed as kinetochores are being mined as a very rich target for the next generations of anti-cancer drugs.

Table of Contents

Centromeres and Kinetochores: An Historical Perspectivep. 1
The Basics of Chromosome Segregationp. 21
The Centromerep. 45
Neocentromeresp. 77
Human Artificial Centromeres: De novo Assembly of Functional Centromeres on Human Artificial Chromosomesp. 107
Kinetochore Composition, Formation, and Organizationp. 133
Evolution of Centromeres and Kinetochores: A Two-Part Fuguep. 193
Mitotic Spindle Assembly Mechanismsp. 231
Kinetochore-Microtubule Interactionsp. 269
Post-Translational Modifications that Regulate Kinetochore Activityp. 293
The Role of the Kinetochore in Spindle Checkpoint Signalingp. 345
Kinetochore Regulation of Anaphase and Cytokinesisp. 371
Roles of Centromeres and Kinetochores in Meiosisp. 395
The Kinetochore-Cancer Connectionp. 433
The Kinetochore as Target for Cancer Drug Developmentp. 455
Indexp. 481
Table of Contents provided by Ingram. All Rights Reserved.

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