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Contributors | p. xi |
Foreword | p. xiii |
Previous Volumes in Series | p. xvii |
Membrane Composition and Properties | |
Membrane Tethers | |
Overview | p. 3 |
Introduction | p. 4 |
Tethers Formed from Bilayer Vesicles | p. 6 |
Tetheis Formed from Red Blood Cells | p. 10 |
Tethers from Neutrophils and Other Cells | p. 16 |
Implications for Cell Adhesion in the Vasculature | p. 19 |
Conclusion | p. 20 |
Future Challenges | p. 21 |
References | p. 22 |
Biomechanics of Leukocyte and Endothelial Cell Surface | |
Overview | p. 25 |
Introduction | p. 26 |
Surface Protrusion and Compression | p. 28 |
Flexural Stiffness of Leukocyte Microvilli | p. 32 |
Membrane Tether Extraction | p. 33 |
Impact of Surface Protrusion and Tether Extraction on Leukocyte Rolling | p. 39 |
Concluding Remarks | p. 40 |
References | p. 41 |
The Cytoskeleton and Deform ability of White Blood Cells | |
Overview | p. 47 |
Introduction | p. 48 |
Passive Deformation of the Cell Contributes to Cell Rolling | p. 50 |
Integrin Activation and Cell Arrest are Dependent on Cell Deformability | p. 57 |
Firmly Adherent Cells Experience Active Deformation | p. 60 |
Cytoskeleton is the Source of Bulk Mechanical Properties of White Blood Cells | p. 63 |
White Blood Cell Deformability can be Measured by Several Rheological Techniques | p. 72 |
Reduced Deformability of White-Blood Cells Leads to Pathologies | p. 88 |
Concluding Remarks | p. 90 |
References | p. 91 |
Adhesion Molecules | |
Activation of Leukocyte Integrins | |
Overview | p. 115 |
Leukocyte Integrins | p. 116 |
Pathology of Integrin Function Deficiency | p. 117 |
Pathology Underlying the Aberrant Integrin Regulation | p. 118 |
Structures of Integrin Heterodimers and Integrin Domains | p. 119 |
Conformational Changes in the ¿ and ß I-Domains | p. 120 |
Global Conformational Changes | p. 122 |
Integrin Activation in Leukocyte-Endothelial Interactions | p. 123 |
Spatiotemporal Regulation of Integrin Activation | p. 125 |
The Role of Integrins in the Interstitial Migration of Leukocytes | p. 126 |
Concluding Remarks | p. 127 |
References | p. 128 |
Cytoskeletal Interactions with Leukocyte and Endothelial Cell Adhesion Molecules | |
Overview | p. 134 |
Introduction | p. 134 |
Integrin Interactions with the Cytoskeleton | p. 134 |
Integrin Cytoplasmic Domain-Binding Proteins in Leukocytes | p. 138 |
Selectin Interactions with the Cytoskeleton | p. 142 |
Immunoglobulin Superfamily Interactions with the Cytoskeleton | p. 146 |
Conclusions | p. 149 |
References | p. 149 |
Membrane-Cytoskeletal Platforms for Rapid Chemokine Signaling to Integrins | |
Overview | p. 158 |
Introduction | p. 159 |
Leukocyte Integrin Activation at Endothelial Contacts | p. 162 |
Signaling Events in Rapid Integrin Activation by GPCRs | p. 172 |
Membranal Platforms for Integrin Activation by Chemokine Signals | p. 178 |
Priming of Integrins to Chemokine Signaling in Rolling Leukocytes | p. 181 |
Conclusions | p. 183 |
References | p. 184 |
Biophysical Regulation of Selectin-Ligand Interactions Under Flow | |
Overview | p. 195 |
Introduction | p. 196 |
Selectins | p. 197 |
Selectin Ligands | p. 197 |
Kinetic and Mechanical Parameters of Cell Tethering and Roiling Under Flow | p. 200 |
Force Free Kinetics and Affinity of Selectin-Ligand Interactions | p. 203 |
Mechanical Regulation of Selectin-Ligand Interactions | p. 204 |
Flow-Enhanced Adhesion: The Shear Threshold Phenomenon | p. 208 |
Cellular Features that Modulate Selectin-Mediated Leukocyte Rolling | p. 211 |
Conclusions | p. 214 |
References | p. 215 |
Modeling Leukocyte Rolling | |
Overview | p. 221 |
Motivation for Modeling Leukocyte Rolling | p. 222 |
History of Modeling Leukocyte Rolling | p. 226 |
Development of a Leukocyte Rolling Model | p. 229 |
Published Modeling Approaches | p. 254 |
Future Directions | p. 264 |
References | p. 266 |
Active Role of Endothelial Cells | |
Endothelial Adhesive Platforms Organize Receptors to Promote Leukocyte Extravasation | |
Overview | p. 277 |
Introduction | p. 278 |
The Emerging Concept of Endothelial Adhesive Platforms | p. 283 |
Concluding Remarks and Therapeutic Perspectives | p. 288 |
Technical Appendix | p. 289 |
References | p. 291 |
Transmigratory Cups and Invadosome-Like Protrusions: New Aspects of Diapedesis | |
Overview | p. 297 |
Introduction | p. 298 |
Endothelial Transmigratory Cups | p. 302 |
Leukocyte Invadosome-Like Protrusions | p. 316 |
Summary and Perspective | p. 326 |
References | p. 327 |
How Endothelial Cells Regulate Transendothelial Migration of Leukocytes: Molecules and Mechanisms | |
Overview | p. 335 |
Introduction | p. 336 |
Endothelial Molecules Regulating Transmigration | p. 337 |
Mechanisms Regulating Transmigration | p. 342 |
Epilogue: Unanswered Questions | p. 351 |
References | p. 351 |
Methods | |
Fluorescence Resonance Energy Transfer in the Studies of Integrin Activation | |
Overview | p. 360 |
Fluorescent Biomolecules | p. 360 |
Fluorescence Techniques | p. 366 |
Summary | p. 381 |
References | p. 382 |
Index | p. 389 |
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