Mass Spectrometry for Drug Discovery and Drug Development

by Korfmacher, Walter A.

• ISBN13: 9780470942383
• ISBN10: 047094238X
• Edition: 1st
• Format: Hardcover
• Copyright: 2013-01-29
• Publisher: Wiley

Summary

This book presents a summary of the ways mass spectrometry is used in various stages of drug discovery and development including early support of medicinal chemistry, drug metabolism studies, distribution, degradation, and various development assays. The book includes a balance of basic and advanced information. Specific chapters relate to various stages in the process (e.g., discovery) as well as chapters on topics of current interest (lipidomics and SiRNA) are covered. Other topics covered include: MS metabolite identification techniques in drug discovery and drug development; Analysis of biological drugs, proteins and peptides; Analysis of drug impurities and degradants; Applications for biomarker discovery and analysis; Applications to support medicinal chemists; and Mass spectrometry for lipidomics applications

Author Biography

WALTER A. KORFMACHER, PhD, is Director of Bioanalysis at Genzyme, a Sanofi company, and Associate Editor at the Journal of Mass Spectrometry. Previously, he held positions at the FDA's National Center for Toxicological Research, Schering-Plough Research Institute, Merck Research Laboratories, and Medpace Bioanalytical Laboratories. Dr. Korfmacher is an international leader in developing mass spectrometry techniques and strategies for new drug discovery and drug metabolism applications. A 2009 recipient of the CPSA Distinguished Analytical Scientist Award, he has published more than 150 articles in the scientific literature and made more than eighty presentations at various scientific forums.

Table of Contents

PREFACE
Walter A. Korfmacher

CONTRIBUTORS

1 Overview of the Various Types of Mass Spectrometers that are Used in Drug Discovery and Drug Development                                                             1
Gérard Hopfgartner

2 Utility of High Resolution Mass Spectrometry for New Drug Discovery Applications
William Bart Emary and Nanyan Rena Zhang

3 Quantitative Mass Spectrometry Considerations in a Regulated Environment 
     

Mohammed Jemal and Yuan-Qing Xia

4 Mass Spectrometry for Quantitative in Vitro ADME Assays                                       

Jun Zhang and Wilson Z. Shou

5 Metabolite Identification Using Mass Spectrometry in Drug Development                                                                                                                                        

Natalia Penner, Joanna Zgoda-Pols and Chandra Prakash

6 MS Analysis of Biological Drugs, Proteins and Peptides                               

Yi Du, John Mehl and Pavlo Pristatsky

7 Characterization of Impurities and Degradation Products in Small Molecule Pharmaceuticals and Biologics                                                         

Hui Wei, Guodong Chen and Adrienne A. Tymiak

8 Liquid Extraction Surface Analysis (LESA): a New Mass Spectrometry-Based Technique for Ambient Surface Profiling                   

Dan Eikel and Jack Henion

9 MS Applications in Support of Medicinal Chemistry Sciences                   

Maarten Honing, Benno Ingelse and Birendra N. Pramanik

10 Imaging Mass Spectrometry of Proteins and Peptides                                              

Michelle L. Reyzer and Richard M. Caprioli

11 Imaging Mass Spectrometry for Drugs and Metabolites                                           

Stacey R. Oppenheimer

12 Screening Reactive Metabolites: Role of Liquid Chromatography-High Resolution Mass Spectrometry in Combination with 'Intelligent' Data Mining Tools                                                              

Shuguang Ma and  Swapan K. Chowdhury

13 Mass Spectrometry of siRNA                                                                                                               

Mark Cancilla and Mike Flanagan

14 Mass Spectrometry for Metabolomics                                                                                             

Petia Shipkova and Michael D. Reily

15 Quantitative Analysis of Peptides with Mass Spectrometry: Selected Reaction Monitoring or High Resolution Full Scan?                               

Lieve Dillen and Filip Cuyckens

Index