Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines Strategies, Technologies, and Applications

by Zhang, Aihua; Wang, Wanying

• ISBN13: 9783527349913
• ISBN10: 352734991X
• Edition: 1st
• Format: Hardcover
• Copyright: 2021-09-07
• Publisher: Wiley-VCH

Summary

Highlights the importance and benefit of mass spectrometry-based metabolomics for identifying biomarkers that accurately screen for potential biomarkers of diseases

Mass spectrometry-based metabolomics offer new opportunities for biomarker discovery in complex diseases and may provide pathological understanding of diseases beyond traditional technologies. It is the systematic analysis of low-molecular-weight metabolites in biological samples and has been applied to discovering and identifying the perturbed pathways. Currently, mass spectrometry-based metabolomics has become an important tool in clinical research and the diagnosis of human disease.

Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines comprehensively presents the current state, challenges, and applications of high-throughput mass spectrometry-based metabolomics such as metabolites analysis, biomarker discovery, technical challenges, discovery of natural product, mechanism interpretation of action, discovery of active ingredients, clinical application and precision medicine, and enhancing their biomedical value in a real world of biomedicine, shedding light on the potential for spectrometry-based metabolomics. It highlights the value of mass spectrometry-based metabolomics and metabolism to address the complexity of herbal medicines in systems pharmacology, especially, to link phytochemical analysis with the assessment of pharmacological effect and therapeutic potential. Each chapter has been laid out with introduction, method, up-to-date literature, identification of biomarker, and applications

• Covers the current state, challenges, and applications of high-throughput mass spectrometry-based metabolomics in the discovery of biomarker, active ingredients, natural product, etc.
• Constitutes a unique and indispensable practical guide for any phytochemistry or related laboratory, and provides hands-on description of new techniques
• Provides a guide for new practitioners of pharmacologists, pharmacological scholars, drug developers, botanist, researchers of traditional medicines.

Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines provides a landmark of mass spectrometry-based metabolomics research and a beneficial guideline to graduate students and researchers in academia, industry, and technology transfer organizations in all biomedical science fields.

Author Biography

Prof. Aihua Zhang is the Laboratory Director of Functional Metabolomics Laboratory, National Chinmedomics Research Center, Sino-America Chinmedomics Technology Collaboration Center, Heilongjiang University of Chinese Medicine, China. He has received numerous scientific awards, including the CHPHARS-SERVIER Young Investigator Awards in Pharmacology, Young and Middle-aged Innovative Talent Award of Chinese Society of Traditional Chinese Medicine, First Prize of Science and Technology Award of Chinese Society of Chinese Medicine, First Prize of Science and Technology Award of China Association of Integrative Medicine, etc. He is also the Deputy Secretary-General of Chinese Medicine Identification Committee of World Federation of Chinese Medicine Societies.
Prof. Dr. Wanying Wang is the research personnel of State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau. She mainly engaged in herbal ingredient analysis and effect evaluation, and has authored over 20 scientific publications.
Prof. Hui Sun is Director of Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, China. She mainly engaged in research work in the fields of quality evaluation and metabolomics analysis of herbal medicine. She has received numerous scientific awards, including the second prizes of the National Science and Technology Progress Award, Second Prize of the National Technical Invention Award, and First Prize of the Provincial Science and Technology Award. She has obtained 16 invention patents and authored over 150 scientific publications.
Dr. Shi Qiu is the research personnel of Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, China. She mainly engaged in new methods of active ingredient analysis of herbal medicine, new technology research of metabolomics/lipidomics, etc. She has won 2 national software copyrights, the First Prize of the Science and Technology Award of the Chinese Society of Chinese Medicine.
Prof. Guangli Yan is the research personnel of Functional Metabolomics Laboratory, National Chinmedomics Research Center, Sino-America Chinmedomics Technology Collaboration Center, Heilongjiang University of Chinese Medicine, China. He mainly engaged in the analysis of in vivo and in vitro components of herbal medicines based on UPLC/MS technology. He has participated in the first prize of Science and Technology of China Association of Integrated Traditional Chinese and Western Medicine, and the first prize of the Science and Technology of China Association of Chinese Medicine, and the first prize of Science and Technology of Heilongjiang province.
Prof. Ying Han is associate researcher at Functional Metabolomics Laboratory, National Chinmedomics Research Center, Sino-America Chinmedomics Technology Collaboration Center, Heilongjiang University of Chinese Medicine, China. Her current research focuses on serum pharmacochemistry of herb medicines and chinmedomics. She obtained her PhD degree in Pharmacognosy from Heilingjiang University of Chinese Medicine in 2015, and then she got the Sasakawa scholarship and worked as a visiting scholar at Nagoya City University from 2016 to 2017. Dr. Ying Han has authored over 20 scientific publications and has received several scientific awards, including First Prize of Science and Technology of Heilongjiang province and First Prize of Chinese Association of Integrative Medicine.

Table of Contents

Chapter 1: Current state of the art of high-throughput metabolomics
Chapter 2: Innovations in analytical techniques of metabolomics
Chapter 3: Sample preparation method for mass spectrometry-based metabolomics
Chapter 4: Multivariate data analysis approach for mass spectrometry-based metabolomics
Chapter 5: Mass spectrometry-driven metabolomics for metabolites and metabolic pathway analysis
Chapter 6: Metabolomics as drivers for biomarker discovery and mechanism interpretation
Chapter 7: Current status of technical challenges in mass spectrometry-driven metabolomics
Chapter 8: The application of metabolomics in cancer management
Chapter 9: Metabolomics in coronary heart disease: From biomarker identification to pathomechanism insights.
Chapter 10: Metabolomics applications in neurological disease
Chapter 11: Metabolomics towards precision medicine
Chapter 12: Mass spectrometry-based metabolomics towards biological function analysis
Chapter 13: Mass spectrometry-driven active ingredients discovery from herbal medicine
Chapter 14: Metabolomics application in herbal medicine
Chapter 15: Mass spectrometry-based metabolomics insights into the mode of action of natural products