9781860941269

Mechanisms of Gene Expression : Structure, Function and Evolution of the Basal Transcriptional Machinery

by
  • ISBN13:

    9781860941269

  • ISBN10:

    1860941265

  • Format: Hardcover
  • Copyright: 1999-08-01
  • Publisher: World Scientific Pub Co Inc

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Table of Contents

Preface v
RNA Polymerases
1(25)
The Evolutionary History of RNA Polymerases
1(2)
Structure and Function of Cellular RNA Polymerase Subunits
3(12)
Other RNA Polymerases
15(5)
Conclusions
20(6)
Basal Factors Recognize Promoters and Assemble the Pre-Initiation Transcription Complexes
26(50)
σ Factors Recruit RNA Polymerases to Different Promoters and Assist Transcript Initiation
27(5)
Simple Beginnings: The Archaeal TATA-Binding Protein (TBP)-TFB-RNAP Initiation Complex
32(4)
Eukaryotic RNAPII Promoters: TATA-Boxes, Initiator Elements and TBP-Associated Factors Responsible for Sequence-Specific Recognition
36(13)
Recruitment of RNAPII/TFIIF
49(1)
Promoter Melting, Transcript Initiation and the Role of TFIIE and TFIIH
50(3)
Re-initiation and Recycling of Basal Factors
53(1)
Basal Factors Reorganize Promoter Topology
54(2)
The RNAPII Holoenzyme
56(9)
Conclusions
65(11)
Gene-Specific Transcription Factors
76(63)
Regulatory Roles of Gene-Specific Transcription Factors in Eukaryotes
78(2)
Mapping of Regulatory Motifs in Eukaryotic Promoters
80(4)
DNA-Binding Domains
84(19)
Activation Domains
103(12)
Functional Modifications of Gene-Specific Transcription Factors
115(7)
Gene-Specific Transcription Factors Shape Overall Promoter Topology
122(3)
Conclusions
125(14)
Coactivators: Interface between Gene-Specific and Basal Transcription Factors
139(48)
Direct Contacts between Gene-Specific Transcription Factors and RNA Polymerase in Bacteria
139(5)
Direct Contacts between Eukaryotic Activators and Eukaryotic RNA Polymerases?
144(2)
The Coactivator Concept in Eukaryotic Transcription
146(3)
TFIID as a Specific Coactivator Complex
149(9)
Tissue-Specific TFIID Complexes
158(6)
Specialized Coactivator/Activator Systems
164(6)
The RNAPII Holoenzyme Mediator Complex
170(3)
General Cofactors. The USA Fraction
173(1)
Conclusions
174(13)
Control of RNA Elongation and Termination
187(48)
Transcription Elongation: Basic Mechanisms
189(5)
The Coding Regions of Genes Contain Transcription Pause and Arrest Sites
194(5)
Control of Elongation `Competence' of RNAPII
199(13)
Transcription Termination in Bacteria
212(10)
Specific Termination of Transcription in Eukaryotes
222(3)
Conclusions
225(10)
RNAPI and RNAPIII Transcriptional Machineries
235(41)
Evolutionary History of the Compartmentalization of Eukaryotic Transcriptional Machinery
235(2)
Structure and Function of the RNAPI Transcriptional Machinery
237(10)
Structure and Function of the RNAPIII Transcriptional Machinery
247(9)
The `Grey Area' between the RNAPII and RNAPIII Transcription Systems: snRNA Genes in Higher Eukaryotes
256(7)
Control of RNAPI and RNAPIII Transcriptional Machineries
263(3)
Conclusions
266(10)
Chromatin
276(48)
The Evolutionary Origin of Chromatin
277(4)
Nucleosome Structure and Function --- The Basics
281(12)
Initiation of Gene-Specific Transcription in Chromatin
293(9)
Chromatin Remodelling of Promoters Packed into Repressive Chromatin Complexes
302(3)
Heritable Maintenance of Gene Expression States through Regulated Heterochromatinization
305(3)
Constitutive Heterochromatin: A Transcriptional Graveyard for Most Genes!
308(5)
Conclusions
313(11)
Nuclear Matrix, Chromosome Scaffolds and Transcriptional Factories
324(19)
What is Nuclear Matrix?
325(1)
Biochemical Composition of the Nuclear Matrix
326(4)
The Nuclear Matrix Organizes Eukaryotic Chromatin into Higher Order Structures
330(7)
Conclusions
337(6)
Gene Expression Dynamics and Global Genome Transcription Patterns
343(33)
The Molecular Quest for Global Genome Transcription Patterns
344(2)
`Proteome' Projects
346(2)
Molecular Characterization of Complex mRNA Populations
348(13)
Detection of Genetic Regulatory Circuits and Identification of Target Genes
361(4)
Defining Genome Transcription Patterns of Single Cells
365(3)
The Ultimate Aim: Monitoring Gene Expression in Real Time
368(3)
Conclusions
371(5)
Appearing on the Horizon: Medical Applications Focusing on Transcriptional Control Mechanisms
376(41)
The Need for Drugs Affecting Gene Expression Patterns
376(2)
Strategies for Identifying Drugs Interfering with Gene-Specific Transcriptional Regulators
378(10)
Reprogramming Transcription Patterns I: Drugs that Control Expression of Genes In Vivo
388(7)
Reprogramming Transcription Patterns II: Drug-Mediated Activation of Alternate Members of Multigene Families
395(4)
Nucleic Acid-Based Gene-Specific Therapeutic Agents
399(7)
Drugs that Control Gene Transcription by Indirect Means
406(11)
Index 417

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