Mechanisms of Heart Failure

by Singal, Pawan K.; Dixon, Ian M. C.; Beamish, Robert E.; Dhalla, Naranjan

• ISBN13: 9780792334903
• ISBN10: 0792334906
• Format: Hardcover
• Copyright: 1995-12-31
• Publisher: Kluwer Academic Pub

Summary

Mechanisms of Heart Failure is based on papers selected from poster presentations made at the International Conference on Heart Failure, Winnipeg, May 20-23, 1994. Although the entire book is one continuous discussion of subcellular mechanisms of heart failure and its treatment, the presentation has been divided into three sections: the opening section on the subcellular basis of heart failure includes discussions of cytokines, signal transduction, metabolism, extracellular matrix, organ level changes and newer approaches to understanding the pathogenesis of heart failure. The second section focuses on the pathophysiological aspects of cardiomyopathies and their treatment. In the final section, medical, surgical and pharmacological approaches to the treatment of heart failure are discussed in clinical and animal laboratory settings.

Table of Contents

Contributing authors
Preface
Acknowledgments
Tumor Necrosis Factor-Alpha in Chronic Heart Failure	p. 3
Myocardial Ribonuclease Activity in Heart Failure	p. 9
[beta]-Adrenergic Receptor Mechanisms in Heart Failure	p. 19
Vascular [alpha]-Adrenergic Function in Congestive heart Failure	p. 37
Altered Myocardial Neurotransmitter and 1,2-Diacylglycerol Concentrations in Right Ventricular Hypertrophy and Failure in Rats	p. 51
Metabolic Changes in Nonischemic Myocardium During Pump Failure	p. 63
Cardiac Extracellular Matrix and its Role in the Development of Heart Failure	p. 75
[actual symbol not reproducible] Rat Model: A Genetic Model of Congestive Heart Failure	p. 91
Left Ventricular Mass and Diastolic Function in Young Individuals with a first elevated "Casual" Blood Pressure	p. 107
Factors Responsible for Left Ventricular Underfilling in Pure Mitral Stenosis	p. 117
Improved Preservation of Myocardial ultrastructure in Perfusion-Fixed Human Heart Explants	p. 129
Involvement of Leukotoxin in the Pathogenesis of Patients with Extensive Burns	p. 143
Differential Regulation of Calmodulin-Dependent Cyclic Nucleotide Phosphodiesterase Isozymes	p. 153
Adriamycin Cardiomyopathy and its Prevention in an Animal Model	p. 169
Alterations in Sarcolemmal Phospholipid Base Exchange Enzymatic Activities in Diabetic Cardiomyopathy	p. 177
Myocardial Lipid Peroxidation and Diabetes	p. 185
Molecular Biologic Changes of Adenine Nucleotide Translocator in J-2-N Cardiomyopathic Hamsters	p. 197
Renin-Angiotensin System and the Congenital Cardiomyopathic Hamster	p. 203
Dietary Mercury Induces Congestive Cardiomyopathy in the Arctic	p. 215
Peripheral Resistance to Atrial Natriuretic Peptide in Patients with Idiopathic Dilated	p. 221
Effect of Ethanol on Allylamine-Induced Subendocardial Fibrosis	p. 239
Nitric Oxide: Friend and Foe in Myocardial Ischemia and Reperfusion	p. 249
Role of Leukocytes and Subcellular Abnormalities in Diastolic Dysfunction During Ischemia-Reperfusion	p. 263
Calcium Channel-Blockade Ameliorates Cardiac Dysfunction and Failure in Ischemic Cardiomyopathy	p. 277
Alterations in Autonomic Nervous System and Heart Mitochondrial Function in Rats Treated with Cyclophosphamide	p. 295
Combined Aerobic and Strength Training in Congestive Heart Failure Patients: Pilot Project on Safety and Feasibility	p. 307
Factors Relating to 6 Minute Walk Performance in Heart Failure Patients	p. 315
Dynamic Cardiomyoplasty: Management of Heart Failure Using Autologous Skeletal Muscle	p. 323
Cardiac Cell Transplantation	p. 337
Effects of Catalase on Volume-Overload Heart Failure	p. 349
Major Determinants of Survival and Nonsurvival of Intra-aortic balloon Pumping	p. 359
End-Stage Ischemic Heart Disease: Effects of Complete Myocardial Revascularization and Left Ventricular Patch Repair Following Scar Resection	p. 369
Acute Enoximone Effect on Systemic Hemodynamics, Renal Function, and Hormonal Activation in Patients with Heart Failure	p. 375
Angiotensin II Receptor Antagonist, E-4177, Inhibits Progression of Reactive Cardiac Hypertrophy Associated with Myocardial Infarction in Rats	p. 387
Effects of Catecholamine and Amrinone on the Metabolism of Noninfarcted Myocardium in Cardiogenic Shock	p. 401
Effects of Angiotensin Converting Enzyme Inhibitors on Acute Heart Failure Induced in the Anesthetized Dog with Microsphere Injection	p. 411
Requirement of Ventricular Function with Adjunctive Nitrate Therapy After Late Reperfusion	p. 425
Neuromuscular Assessment of Heart Failure Patients	p. 433
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