A Brief History of Microbiology | p. 1 |
The Early Years of Microbiology | p. 2 |
What Does Life Really Look Like? | p. 2 |
How Can Microbes Be Classified? | p. 3 |
The Golden Age of Microbiology | p. 7 |
Is Spontaneous Generation of Microbial Life Possible? | p. 7 |
What Causes Fermentation? | p. 10 |
What Causes Disease? | p. 10 |
How Can We Prevent Infection and Disease? | p. 16 |
The Modern Age of Microbiology | p. 18 |
What Are the Basic Chemical Reactions of Life? | p. 19 |
How Do Genes Work? | p. 19 |
What Roles Do Microorganisms Play in the Environment? | p. 21 |
How Do We Defend Against Disease? | p. 21 |
What Will the Future Hold? | p. 21 |
Chapter Summary | p. 22 |
Questions for Review | p. 23 |
The Chemistry of Microbiology | p. 25 |
Atoms | p. 26 |
Atomic Structure | p. 26 |
Isotopes | p. 26 |
Electron Configurations | p. 27 |
Chemical Bonds | p. 28 |
Nonpolar Covalent Bonds | p. 29 |
Polar Covalent Bonds | p. 31 |
Ionic Bonds | p. 32 |
Hydrogen Bonds | p. 33 |
Chemical Reactions | p. 34 |
Synthesis Reactions | p. 34 |
Decomposition Reactions | p. 34 |
Exchange Reactions | p. 35 |
Water, Acids, Bases, and Salts | p. 35 |
Water | p. 35 |
Acids and Bases | p. 37 |
Salts | p. 38 |
Organic Macromolecules | p. 38 |
Functional Groups and Monomers | p. 38 |
Lipids | p. 39 |
Carbohydrates | p. 42 |
Proteins | p. 46 |
Nucleic Acids | p. 49 |
Chapter Summary | p. 52 |
Questions for Review | p. 53 |
Cell Structure and Function | p. 55 |
Processes of Life | p. 56 |
Eukaryotic and Prokaryotic Cells: An Overview | p. 57 |
External Structures of Prokaryotic Cells | p. 60 |
Glycocalyces | p. 60 |
Flagella | p. 61 |
Fimbriae and Pili | p. 64 |
Prokaryotic Cell Walls | p. 65 |
Bacterial Cell Walls | p. 65 |
Archaeal Cell Walls | p. 67 |
Prokaryotic Cytoplasmic Membranes | p. 69 |
Structure | p. 69 |
Function | p. 70 |
Cytoplasm of Prokaryotes | p. 74 |
Cytosol | p. 74 |
Inclusions | p. 74 |
Endospores | p. 74 |
Nonmembranous Organelles | p. 76 |
External Structure of Eukaryotic Cells | p. 77 |
Glycocalyces | p. 77 |
Eukaryotic Cell Walls and Cytoplasmic Membranes | p. 77 |
Cytoplasm of Eukaryotes | p. 80 |
Flagella | p. 80 |
Cilia | p. 81 |
Other nonmembranous Organelles | p. 81 |
Membranous Organelles | p. 82 |
Endosymbiotic Theory | p. 85 |
Chapter Summary | p. 88 |
Questions for Review | p. 90 |
Microscopy, Staining, and Classification | p. 93 |
Units of Measurement | p. 94 |
Microscopy | p. 94 |
General Principles of Microscopy | p. 94 |
Light Microscopy | p. 96 |
Electron Microscopy | p. 102 |
Probe Microscopy | p. 104 |
Staining | p. 105 |
Preparing Specimens for Staining | p. 105 |
Principles of Staining | p. 107 |
Simple Stains | p. 107 |
Differential Stains | p. 107 |
Special Stains | p. 110 |
Staining for Electron Microscopy | p. 112 |
Classification and Identification of Microorganisms | p. 112 |
Linnaeus, Whitaker, and Taxonomic Categories | p. 112 |
Domains | p. 115 |
Taxonomic and Identifying Characteristics | p. 115 |
Taxonomic Keys | p. 119 |
Chapter Summary | p. 120 |
Questions for Review | p. 121 |
Microbial Metabolism | p. 123 |
Basic Chemical Reactions Underlying Metabolism | p. 124 |
Catabolism and Anabolism | p. 124 |
Oxidation and Reduction Reactions | p. 125 |
ATP Production and Energy Storage | p. 126 |
The Roles of Enzymes in Metabolism | p. 126 |
Carbohydrate Catabolism | p. 133 |
Glycolysis | p. 134 |
Alternatives to Glycolysis | p. 137 |
Continuation of Cellular Respiration | p. 139 |
Fermentation | p. 146 |
Other Catabolic Pathways | p. 147 |
Lipid Catabolism | p. 147 |
Protein Catabolism | p. 149 |
Photosynthesis | p. 149 |
Chemicals and Structures | p. 150 |
Light-Dependent Reactions | p. 151 |
Light-Independent Reactions | p. 154 |
Other Anabolic Pathways | p. 154 |
Carbohydrate Biosynthesis | p. 155 |
Lipid Biosynthesis | p. 156 |
Amino Acid Biosynthesis | p. 156 |
Nucleotide Biosynthesis | p. 158 |
Integration and Regulation of Metabolic Functions | p. 158 |
Chapter Summary | p. 161 |
Questions for Review | p. 162 |
Microbial Nutrition and Growth | p. 165 |
Growth Requirements | p. 166 |
Nutrients: Chemical and Energy Requirements | p. 166 |
Physical Requirements | p. 170 |
Ecological Associations | p. 174 |
Culturing Microorganisms | p. 174 |
Clinical Sampling | p. 175 |
Obtaining Pure Cultures | p. 176 |
Culture Media | p. 178 |
Special Culture Techniques | p. 182 |
Preserving Cultures | p. 184 |
Growth of Microbial Populations | p. 184 |
Mathematical Considerations in Population Growth | p. 185 |
Generation Time | p. 185 |
Phases of Microbial Growth | p. 186 |
Measuring Microbial Growth | p. 187 |
Chapter Summary | p. 192 |
Questions for Review | p. 194 |
Microbial Genetics | p. 196 |
The Structure and Replication of Genomes | p. 197 |
The Structure of Nucleic Acids | p. 197 |
The Structure of Prokaryotic Genomes | p. 197 |
The Structure of Eukaryotic Genomes | p. 200 |
DNA Replication | p. 201 |
Gene Function | p. 205 |
The Relationship Between Genotype and Phenotype | p. 205 |
The Transfer of Genetic Information | p. 206 |
The Events in Transcription | p. 206 |
Translation | p. 210 |
Regulation of Genetic Expression | p. 216 |
Mutations of Genes | p. 220 |
Types of Mutations | p. 220 |
Effects of Mutations | p. 220 |
Mutagens | p. 220 |
Frequency of Mutation | p. 223 |
DNA Repair | p. 223 |
Identifying Mutants, Mutagens, and Carcinogens | p. 225 |
Genetic Recombination and Transfer | p. 227 |
Horizontal Gene Transfer Among Prokaryotes | p. 227 |
Transposons and Transposition | p. 232 |
Chapter Summary | p. 234 |
Questions for Review | p. 236 |
Recombinant DNA Technology | p. 239 |
The Role of Recombinant DNA Technology in Biotechnology | p. 240 |
The Tools of Recombinant DNA Technology | p. 240 |
Mutagens | p. 240 |
The Use of Reverse Transcriptase to Synthesize cDNA | p. 241 |
Synthetic Nucleic Acids | p. 241 |
Restriction Enzymes | p. 242 |
Vectors | p. 243 |
Gene libraries | p. 244 |
Techniques of Recombinant DNA Technology | p. 245 |
Multiplying DNA in vitro: The Polymerase Chain Reaction (PCR) | p. 245 |
Selecting a Clone of Recombinant Cells | p. 246 |
Separating DNA Molecules: Gel Electrophoresis and the Southern Blot | p. 246 |
DNA Microarrays | p. 249 |
Inserting DNA into Cells | p. 250 |
Applications of Recombinant DNA Technology | p. 250 |
Genome Mapping | p. 250 |
Pharmaceutical and Therapeutic Applications | p. 253 |
Agricultural Applications | p. 256 |
The Ethics and Safety of Recombinant DNA Technology | p. 257 |
Chapter Summary | p. 258 |
Questions for Review | p. 259 |
Controlling Microbial Growth in the Environment | p. 261 |
Basic Principles of Microbial Control | p. 262 |
Terminology of Microbial Control | p. 262 |
Microbial Death Rates | p. 263 |
Action of Antimicrobial Agents | p. 264 |
The Selection of Microbial Control Methods | p. 264 |
Factors Affecting the Efficacy of Antimicrobial Methods | p. 264 |
Methods for Evaluating Disinfectants and Antiseptics | p. 265 |
Physical Methods of Microbial Control | p. 267 |
Heat-Related Methods | p. 267 |
Refrigeration and Freezing | p. 270 |
Desiccation and Lyophilization | p. 271 |
Filtration | p. 271 |
Osmotic Pressure | p. 273 |
Radiation | p. 273 |
Chemical Methods of Microbial Control | p. 276 |
Phenol and Phenolics | p. 276 |
Alcohols | p. 277 |
Halogens | p. 277 |
Oxidizing Agents | p. 278 |
Surfactants | p. 278 |
Heavy Metals | p. 278 |
Aldehydes | p. 279 |
Gaseous Agents | p. 280 |
Antimicrobials | p. 281 |
Development of Resistant Microbes | p. 281 |
Chapter Summary | p. 282 |
Questions for Review | p. 283 |
Controlling Microbial Growth in the Body: Antimicrobial Drugs | p. 286 |
The History of Antimicrobial Agents | p. 287 |
Mechanisms of Antimicrobial Action | p. 288 |
Inhibition of Cell Wall Synthesis | p. 289 |
Inhibition of Protein Synthesis | p. 291 |
Disruption of Cytoplasmic Membranes | p. 292 |
Inhibition of Metabolic Pathways | p. 293 |
Inhibition of Nucleic Acid Synthesis | p. 294 |
Prevention of Virus Attachment | p. 296 |
Clinical Considerations in Prescribing Antimicrobial Drugs | p. 296 |
Spectrum of Action | p. 296 |
Efficacy | p. 297 |
Routes of Administration | p. 299 |
Safety and Side Effects | p. 300 |
Resistance to Antimicrobial Drugs | p. 301 |
The Development of Resistance in Populations | p. 301 |
Mechanisms of Resistance | p. 302 |
Multiple Resistance and Cross Resistance | p. 303 |
Retarding Resistance | p. 303 |
Chapter Summary | p. 312 |
Questions for Review | p. 313 |
Characterizing and Classifying Prokaryotes | p. 315 |
General Characteristics of Prokaryotic Organisms | p. 316 |
Morphology of Prokaryotic Cells | p. 316 |
Reproduction of Prokaryotic Cells | p. 316 |
Arrangements of Prokaryotic Cells | p. 317 |
Endospores | p. 318 |
Modern Prokaryotic Classification | p. 319 |
Survey of Archaea | p. 320 |
Extremophiles | p. 321 |
Methanogens | p. 323 |
Survey of Bacteria | p. 323 |
Deeply Branching and Phototrophic Bacteria | p. 323 |
Low G + C Gram-Positive Bacteria | p. 326 |
High G + C Gram-Positive Bacteria | p. 330 |
Gram-Negative Proteobacteria | p. 331 |
Other Gram-Negative Bacteria | p. 338 |
Chapter Summary | p. 339 |
Questions for Review | p. 341 |
Characterizing and Classifying Eukaryotes | p. 343 |
General Characteristics of Eukaryotic Organisms | p. 344 |
Reproduction in Eukaryotes | p. 344 |
The Classification of Eukaryotic Organisms | p. 348 |
Protozoa | p. 349 |
Distribution of Protozoa | p. 349 |
Morphology of Protozoa | p. 349 |
Nutrition of Protozoa | p. 350 |
Reproduction in Protozoa | p. 350 |
Classification of Protozoa | p. 352 |
Fungi | p. 357 |
The Significance of Fungi | p. 358 |
Morphology of Fungi | p. 359 |
Nutrition of Fungi | p. 360 |
Reproduction in Fungi | p. 360 |
Classification of Fungi | p. 362 |
Lichens | p. 367 |
Algae | p. 368 |
Distribution of Algae | p. 368 |
Morphology of Algae | p. 368 |
Reproduction in Algae | p. 368 |
Classification of Algae | p. 369 |
Water Molds | p. 373 |
Other Eukaryotes of Microbiological Interest: Parasitic Helminths and Vectors | p. 373 |
Chapter Summary | p. 373 |
Questions for Review | p. 375 |
Characterizing and Classifying Viruses, Viroids, and Prions | p. 377 |
Characteristics of Viruses | p. 378 |
Genetic Material of Viruses | p. 379 |
Hosts of Viruses | p. 379 |
Sizes of Viruses | p. 380 |
Capsid Morphology | p. 380 |
Viral Shapes | p. 381 |
The Viral Envelope | p. 381 |
Classification of Viruses | p. 382 |
Viral Replication | p. 385 |
Lytic Replication of Bacteriohages | p. 385 |
Lysogeny | p. 388 |
Replication of Animal Viruses | p. 390 |
The Role of Viruses in Cancer | p. 394 |
Culturing Viruses in the Laboratory | p. 396 |
Culturing Viruses in Whole Organisms | p. 396 |
Culturing Viruses in Embryonated Chicken Eggs | p. 396 |
Culturing Viruses in Cell (Tissue) Culture | p. 397 |
Other Parasitic Particles: Viroids and Prions | p. 398 |
Characteristics of Viroids | p. 398 |
Characteristics of Prions | p. 398 |
Are Viruses Alive? | p. 401 |
Chapter Summary | p. 401 |
Questions for Review | p. 402 |
Infection, Infectious Diseases, and Epidemiology | p. 404 |
Symbiotic Relationships Between Microbes and Their Hosts | p. 405 |
Types of Symbiosis | p. 405 |
Normal Microbiota in Hosts | p. 406 |
How Normal Microbiota Become Opportunistic Pathogens | p. 407 |
The Movement of Microbes into Hosts: Infection | p. 409 |
Exposure to Microbes: Contamination and Infection | p. 409 |
Portals of Entry | p. 409 |
The Role of Adhesion in Infection | p. 410 |
The Nature of Infectious Disease | p. 411 |
Manifestations of Disease: Symptoms, Signs, and Syndromes | p. 412 |
Causation of Disease: Etiology | p. 412 |
Virulence Factors of Infectious Agents | p. 415 |
The Stages of Infectious Diseases | p. 418 |
The Movement of Pathogens Out of Hosts: Portals of Exit | p. 419 |
Sources of Infectious Diseases in Humans | p. 419 |
Animal Reservoirs | p. 420 |
Human Carriers | p. 420 |
Nonliving Reservoirs | p. 420 |
Modes of Infectious Disease Transmission | p. 420 |
Contact Transmission | p. 422 |
Vehicle Transmission | p. 423 |
Vector Transmission | p. 423 |
Classification of Infectious Diseases | p. 423 |
Epidemiology of Infectious Diseases | p. 424 |
Frequency of Disease | p. 425 |
Epidemiological Studies | p. 426 |
Hospital Epidemiology: Nosocomial Infections | p. 430 |
Epidemiology and Public Health | p. 432 |
Chapter Summary | p. 433 |
Questions for Review | p. 435 |
Innate Immunity | p. 437 |
An Overview of the Body's Defenses | p. 438 |
The Body's First Line of Defense | p. 438 |
The Role of Skin in Nonspecific Defense | p. 438 |
The Role of Mucous Membranes in Nonspecific Defense | p. 439 |
The Role of Normal Microbiota in Nonspecific Defense | p. 440 |
Other First-Line Defenses | p. 441 |
An Overview of the Body's Second Line of Defense | p. 442 |
Defense Components of Blood | p. 443 |
The Body's Second Line of Defense | p. 445 |
Phagocytosis | p. 445 |
Extracellular Killing by Leukocytes | p. 448 |
Nonspecific Chemical Defenses Against Pathogens | p. 449 |
Inflammation | p. 452 |
Fever | p. 456 |
Chapter Summary | p. 458 |
Questions for Review | p. 459 |
Specific Defense: Adaptive Immunity | p. 461 |
Elements of Adaptive Immunity (Specific) | p. 462 |
Antigens | p. 462 |
The Cells, Tissues, and Organs of the Lymphatic System | p. 464 |
B Lymphocytes (B Cells) and Antibodies | p. 466 |
T Lymphocytes (T Cells) | p. 469 |
Immune System Cytokines | p. 471 |
The Body's Preparation for a Specific Adaptive Immune Response | p. 472 |
Lymphocyte Editing by Clonal Deletion | p. 472 |
The Roles of the Major Histocompatibility Complex | p. 473 |
Antigen Processing | p. 474 |
The Humoral Immune Response | p. 476 |
B Cell Activation and Clonal Selection | p. 476 |
Memory B Cells and the Establishment of Immunological Memory | p. 476 |
The Cell-Mediated Immune Response | p. 478 |
The Perforin-Granzyme Cytotoxic Pathway | p. 479 |
The CD95 Cytotoxic Pathway | p. 480 |
Memory T Cells | p. 480 |
T Cell Regulation | p. 480 |
Types of Acquired Immunity | p. 481 |
Naturally Acquired Active Immunity | p. 481 |
Naturally Acquired Passive Immunity | p. 481 |
Artificially Acquired Active Immunity | p. 481 |
Artificially Acquired Passive Immunity | p. 481 |
Chapter Summary | p. 482 |
Questions for Review | p. 483 |
Immunization and Immune Testing | p. 485 |
Immunization | p. 486 |
Brief History of Immunization | p. 486 |
Active Immunization | p. 487 |
Passive Immunization | p. 492 |
Immune Testing | p. 493 |
Precipitation Tests | p. 494 |
Agglutination Tests | p. 497 |
Neutralization Tests | p. 498 |
The Complement Fixation Test | p. 498 |
Labeled Antibody Tests | p. 499 |
Recent Developments in Immune Testing | p. 502 |
Chapter Summary | p. 504 |
Questions for Review | p. 505 |
Hypersensitivities, Autoimmune Diseases, and Immune Deficiencies | p. 507 |
Hypersensitivities | p. 508 |
(Immediate) Hypersensitivity | p. 508 |
(Cytotoxic) Hypersensitivity | p. 512 |
(Immune-Complex Mediated) Hypersensitivity | p. 515 |
(Delayed or Cell-Mediated) Hypersensitivity | p. 516 |
Autoimmune Diseases | p. 521 |
Causes of Autoimmune Diseases | p. 521 |
Single Tissue Autoimmune Diseases | p. 522 |
Systemic Autoimmune Diseases | p. 522 |
Immunodeficiency Diseases | p. 524 |
Primary Immunodeficiency Diseases | p. 524 |
Acquired Immunodeficiency Diseases | p. 525 |
Chapter Summary | p. 526 |
Questions for Review | p. 527 |
Pathogenic Gram-Positive Cocci and Bacilli | p. 529 |
Staphylococcus | p. 530 |
Structure and Physiology | p. 530 |
Pathogenicity | p. 531 |
Epidemiology | p. 531 |
Staphylococcal Diseases | p. 532 |
Diagnosis, Treatment, and Prevention | p. 534 |
Streptococcus | p. 535 |
Group A Streptococcus: Streptococcus pyogenes | p. 535 |
Group B Streptococcus: Streptococcus agalactiae | p. 538 |
Other Beta-Hemolytic Streptococci | p. 538 |
Alpha-Hemolytic Streptococci: The Viridans Group | p. 539 |
Streptococcus pneumoniae | p. 539 |
Enterococcus | p. 540 |
Structure and Physiology | p. 541 |
Pathogenesis, Epidemiology, and Diseases | p. 541 |
Diagnosis, Treatment, and Prevention | p. 541 |
Bacillus | p. 542 |
Structure, Physiology, and Pathogenicity | p. 542 |
Epidemiology | p. 543 |
Disease | p. 543 |
Diagnosis, Treatment, and Prevention | p. 544 |
Clostridium | p. 544 |
Clostridium perfringens | p. 544 |
Clostridium difficile | p. 545 |
Clostridium botulinum | p. 545 |
Clostridium tetani | p. 548 |
Listeria | p. 550 |
Pathogenesis, Epidemiology, and Disease | p. 550 |
Diagnosis, Treatment, and Prevention | p. 550 |
Corynebacterium | p. 551 |
Pathogenesis, Epidemiology, and Disease | p. 552 |
Diagnosis, Treatment, and Prevention | p. 552 |
Mycobacterium | p. 553 |
Tuberculosis | p. 553 |
Leprosy | p. 557 |
Other Mycobacterial Infections in AIDS Patients | p. 558 |
Propionibacterium | p. 558 |
Nocardia and Actinomyces | p. 558 |
Nocardia asteroides | p. 559 |
Actinomyces | p. 560 |
Chapter Summary | p. 560 |
Questions for Review | p. 562 |
Pathogenic Gram-Negative Cocci and Bacilli | p. 564 |
Pathogenic Gram-Negative Cocci: Neisseria | p. 565 |
Structure and Physiology of Neisseria | p. 565 |
The Gonococcus: Neisseria gonorrhoeae | p. 566 |
The Meningococcus: Neisseria meningitidis | p. 567 |
Pathogenic, Gram-Negative, Facultatively Anaerobic Bacilli | p. 569 |
The Enterobacteriaceae: An Overview | p. 569 |
Coliform Opportunistic Enterobacteriaceae | p. 572 |
Noncoliform Opportunistic Enterobacteriaceae | p. 575 |
Truly Pathogenic Enterobacteriaceae | p. 576 |
The Pasteurellaceae | p. 580 |
Pathogenic, Gram-Negative, Aerobic Bacilli | p. 582 |
Bartonella | p. 582 |
Brucella | p. 582 |
Bordetella | p. 583 |
Burkholderia | p. 585 |
Pseudomonads | p. 586 |
Francisella | p. 587 |
Legionella | p. 588 |
Coxiella | p. 589 |
Pathogenic, Gram-Negative, Anaerobic Bacilli | p. 590 |
Bacteroides | p. 590 |
Prevotella | p. 591 |
Chapter Summary | p. 591 |
Questions for Review | p. 592 |
Mycoplasmas, Rickettsias, Chlamydias, Spirochetes, and Vibrios | p. 594 |
Mycoplasmas | p. 595 |
Mycoplasma pneumoniae | p. 596 |
Other Mycoplasmas | p. 596 |
Rickettsias | p. 597 |
Rickettsia | p. 597 |
Orienta | p. 599 |
Ehrlichia | p. 600 |
Chlamydias | p. 601 |
Chlamydia trachomatis | p. 602 |
Chlamydia pneumoniae | p. 604 |
Chlamydia psittaci | p. 604 |
Spirochetes | p. 606 |
Treponema | p. 606 |
Borrelia | p. 609 |
Leptospira | p. 612 |
Pathogenic Gram-Negative Vibrios | p. 613 |
Vibrio | p. 613 |
Campylobacter jejuni | p. 615 |
Helicobacter pylori | p. 616 |
Chapter Summary | p. 618 |
Questions for Review | p. 619 |
Pathogenic Fungi | p. 622 |
An Overview of Medical Mycology | p. 623 |
The Epidemiology of Mycoses | p. 623 |
Categories of Fungal Agents: True Fungal Pathogens and Opportunistic Fungi | p. 623 |
Clinical Manifestations of Fungal Diseases | p. 625 |
The Diagnosis of Fungal Infections | p. 626 |
Antifungal Therapies | p. 626 |
Systemic Mycoses Caused by Pathogenic Fungi | p. 627 |
Blastomycosis | p. 627 |
Coccidioidomycosis | p. 628 |
Histoplasmosis | p. 629 |
Paracoccidioidomycosis | p. 629 |
Systemic Mycoses Caused by Opportunistic Fungi | p. 631 |
Aspergillosis | p. 631 |
Candidiasis | p. 632 |
Cryptococcosis | p. 634 |
Pneumocystis Pneumonia | p. 635 |
Zygomycoses | p. 636 |
The Emergence of Fungal Opportunists in Immunosuppressed Individuals | p. 636 |
Superficial, Cutaneous, and Subcutaneous Mycoses | p. 637 |
Superficial Mycoses | p. 637 |
Cutaneous and Subcutaneous Mycoses | p. 640 |
Fungal Intoxications and Allergies | p. 642 |
Mycotoxicoses | p. 642 |
Mycetismus: Mushroom Poisoning | p. 643 |
Allergies to Fungi | p. 643 |
Chapter Summary | p. 644 |
Questions for Review | p. 645 |
Parasitic Protozoa, Helminths, and Arthropod Vectors | p. 648 |
Protozoan Parasites of Humans | p. 650 |
Ciliates | p. 650 |
Amoebae | p. 650 |
Flagellates | p. 652 |
Apicomplexans | p. 658 |
Helminthic Parasites of Humans | p. 663 |
Cestodes | p. 664 |
Trematodes | p. 666 |
Nematodes | p. 669 |
Arthropod Vectors | p. 672 |
Arachnids | p. 673 |
Insects | p. 673 |
Chapter Summary | p. 675 |
Questions for Review | p. 676 |
Pathogenic DNA Viruses | p. 679 |
Poxviridae | p. 680 |
Smallpox | p. 680 |
Molluscum Contagiosum | p. 682 |
Other Poxvirus Infections | p. 682 |
Herpesviridae | p. 682 |
Infections of Human Herpesviruses 1 and 2 | p. 683 |
Varicella-Zoster Virus Infections | p. 687 |
Epstein-Barr Virus Infections | p. 689 |
Cytomegalovirus Infections | p. 691 |
Other Herpesvirus Infections | p. 692 |
Papillomaviridae and Polyomaviridae | p. 692 |
Papillomavirus Infections | p. 693 |
Polyomavirus Infections | p. 694 |
Adenoviridae | p. 695 |
Hepadnaviridae | p. 696 |
Hepatitis B Infections | p. 697 |
The Role of Hepatitis B Virus in Hepatic Cancer | p. 699 |
Parvoviridae | p. 699 |
Chapter Summary | p. 700 |
Questions for Review | p. 701 |
Pathogenic RNA Viruses | p. 703 |
Naked, Positive ssRNA Viruses: Picornaviridae, Caliciviridae, Astroviridae, and Hepeviridae | p. 704 |
Common Colds Caused by Rhinoviruses | p. 704 |
Diseases of Enteroviruses | p. 705 |
Hepatitis A | p. 708 |
Acute Gastroenteritis and Hepatitis E | p. 709 |
Enveloped, Positive ssRNA Viruses: Togaviridae, Flaviviridae, and Coronaviridae | p. 710 |
Diseases of +RNA Arboviruses | p. 710 |
Other Diseases of Enveloped +ssRNA Viruses | p. 710 |
Rubella | p. 713 |
Hepatitis C | p. 714 |
Diseases of Coronaviruses | p. 715 |
Enveloped, Positive ssRNA Viruses with Reverse Transcriptase: Retroviridae | p. 715 |
Oncogenic Retroviruses | p. 717 |
Acquired Immunodeficiency Syndrome | p. 717 |
Enveloped, Unsegmented, Negative ssRNA Viruses: Paramyxoviridae, Rhabdoviridae, and Filoviridae | p. 724 |
Measles | p. 724 |
Diseases of Parainfluenza Virus | p. 726 |
Mumps | p. 726 |
Disease of Respiratory Syncytial Virus | p. 727 |
Rabies | p. 728 |
Hemorrhagic Fevers | p. 730 |
Enveloped, Segmented, Negative ssRNA Viruses: Orthomyxoviridae, Bunyaviridae, and Arenaviridae | p. 731 |
Influenza | p. 731 |
Diseases of Bunyaviruses | p. 735 |
Diseases of Arenaviruses | p. 735 |
Naked, Segmented dsRNA Viruses: Reoviridae | p. 736 |
Rotaviruses | p. 736 |
Coltiviruses | p. 737 |
Chapter Summary | p. 738 |
Questions for Review | p. 740 |
Applied and Environmental Microbiology | p. 742 |
Food Microbiology | p. 743 |
The Roles of Microorganisms in Food Production | p. 743 |
The Causes and Prevention of Food Spoilage | p. 747 |
Food-Borne Illnesses | p. 750 |
Industrial Microbiology | p. 751 |
The Roles of Microbes in Industrial Fermentations | p. 751 |
Industrial Products of Microorganisms | p. 752 |
Water and Wastewater Treatment | p. 754 |
Bioremediation | p. 760 |
The Problem of Acid Mine Drainage | p. 761 |
Environmental Microbiology | p. 762 |
Microbial Ecology | p. 762 |
The Roles of Microorganisms in Biogeochemical Cycles | p. 764 |
Soil Microbiology | p. 767 |
Aquatic Microbiology | p. 768 |
Biological Warfare and Bioterrorism | p. 771 |
Assessing Microorganisms as Potential Agents of Warfare or Terror | p. 771 |
Known Microbial Threats | p. 772 |
Defense Against Bioterrorism | p. 772 |
The Roles of Recombinant Genetic Technology in Bioterrorism | p. 774 |
Chapter Summary | p. 774 |
Questions for Review | p. 776 |
Metabolic Pathways | p. 1 |
Some Mathematical Considerations in Microbiology | p. 1 |
Classification of Bacteria According to Bergey's Manual | p. 1 |
Major Microbial Agents of Disease by Body System Affected | p. 1 |
Answers to End-of-Chapter Questions | p. 1 |
Glossary | p. 1 |
Index | p. 1 |
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