Micrornas in Medicine

by Lawrie, Charles H.

• ISBN13: 9781118300398
• ISBN10: 1118300394
• Edition: 1st
• Format: Hardcover
• Copyright: 2014-01-28
• Publisher: Wiley-Blackwell

Summary

MicroRNAs in Medicine provides an access point into the current literature on microRNA for both scientists and clinicians, with an up-to-date look at what is happening in the emerging field of microRNAs and their relevance to medicine. Each chapter is a comprehensive review, with descriptions of the latest microRNA research written by international leaders in their field. Opening with an introduction to what microRNAs are and how they function, the book goes on to explore the role of microRNAs in normal physiological functions, infectious diseases, non-infectious diseases, cancer, circulating microRNAs as non-invasive biomarkers, and finally their potential as novel therapeutics.

Including background information on the field as well as reviews of the latest research breakthroughs, MicroRNAs in Medicine is a one-stop source of information to satisfy the specialists and non-specialists alike, appealing to students, researchers, and clinicians interested in understanding the potential of microRNAs in medicine and research.

Author Biography

Dr. Charles Lawrie is Director of Oncology at the Biodonostia Institute in San Sebastián, Spain. The author of numerous research papers and book chapters, Dr. Lawrie is an Associate Editor for the Journal of Cancer Research, and serves on the editorial boards of a number of other prestigious journals including Cancers, Journal of RNAi and Gene Silencing, American Journal of Blood, and ISRN Hematology.

Table of Contents

Introduction to microRNAs- history, form and function - Prof. Charles Lawrie (Biodonostia Institute, San Sebastian, Spain & University of Oxford)
Section I: MicroRNAs as physiological regulators
1.1 MicroRNAs, stem cells and cellular differentiation
Chapter 1. MicroRNAs as regulators of cell fate and differentiation- Prof. Deepak Srivastava (Gladstone Institute of Cardiovascular Disease, CA)
Chapter 2. A functional approach to identifying essential microRNAs (and target genes) involved in embryonic stem cell fate- Prof. Azim Surani (Cambridge University)
1.2 MicroRNA in immunity
Chapter 3. miR-155 is an essential regulator of adaptive immunity - Dr Elena Vigorito (Cambridge University)
Chapter 4. MicroRNA control of innate immune response to intracellular bacterial infections - Prof. Xuetao Cao (Chinese Academy of Medical Sciences, Beijing)
1.3 MicroRNAs and aging
Chapter 5. MicroRNA involvement in aging and chronic DNA damage - Prof. Carlos Lopez-Otin (Oviedo University, Spain)
Chapter 6. MicroRNA regulation of senescence - Dr Myriam Gorospe (National Institute of Aging, Baltimore)
1.4 MicroRNAs in hematopoiesis
Chapter 7. MicroRNAs as regulators of hematopoiesis - Prof. Ramiro Garzon (Ohio State University)
Chapter 8. Activation and production of platelets by microRNAs - Dr Paul Bray (Thomas Jefferson University, PA)

Section II: Infectious disease: Exploitation of microRNAs by pathogens
Chapter 9. MicroRNA expression in herpesviruses- Prof. Bryan Cullen (Duke University)
Chapter 10. MicroRNA expression in Marek's disease virus - Prof. Venu Gopal (IAH, Compton)
Chapter 11. HIV infection, immunity and microRNAs- Dr Mary Carrington (National Cancer Institute, MD)
Chapter 12. MicroRNA changes in response to cerebral malaria- Dr Panote Panoslip & Dr Gareth Turner (Oxford University)
Chapter 13. Host microRNA response to Salmonella infections- Prof. Jorg Vogel (Institut für Molekulare Infektionsbiologie, Warzburg, Germany)
Chapter 14. Kaposi's Sarcoma-Associated Herpesvirus miRNAs and their Roles in B Cell Development and Tumorgenesis- Prof. Rolf Renne (University of Florida)

Section III: Non-infectious diseases
3.1 Neurological disorders
Chapter 15. Role of microRNAs in Alzheimer's disease - Prof. Hermona Soreq (University of Jerusalem, Israel)
Chapter 16. MicroRNA dysregulation and psychiatric disease¬- Prof. Claes Wahlestedt (Scripps Florida)
3.2 Heart disease
Chapter 17. MicroRNAs and cardiovascular disease - Prof. Koh Ono (Kyoto University, Japan)
Chapter 18. miR-499 as a protector of cardiomyocytes and potential therapeutic for myocardial infarction - Prof. Pei-Feng Li (Chinese Academy of Sciences, Beijing, China)
3.3 Hereditary disorders
Chapter 19. Altered microRNA regulation in Huntington's disease models- Prof. Manho Kim ( Seoul National University Hospital, Korea)
Chapter 20. MicroRNA regulation in multiple sclerosis- Prof. Edgar Meinl (Max Planck Institute of Neurobiology, Munich, Germany)

Section IV: MicroRNAs and cancer
4.1 Aberrant expression of microRNAs is a ubiquitous feature of cancer
Chapter 21. The majority of miRNAs associated with cancer are located at cancer hotspots - Prof. George Calin (Ohio State University)
Chapter 22. MicroRNAs as oncomirs and tumor suppressors- Prof. Scott Hammond (University of North Carolina)
4.2 Breast cancer
Chapter 23. Deep sequencing analysis of the breast cancer miRnome- Prof. Thomas Tushcl (Rockefellar University)
Chapter 24. Regulation of hypoxia by microRNA expression in breast cancer - Prof. Adrian Harris (Oxford University)
Chapter 25. Control of hormone receptors by microRNAs in breast cancer- Dr Marilena Iorio (Istituto Tumori, Milan)
4.3 Hematological malignancies
Chapter 26. MicroRNA involvement in CLL pathogenesis ¬- Prof. Carlo Croce (Ohio State University)
Chapter 27. MicroRNAs as indicators of prognosis in diffuse large B-cell lymphoma - Prof. Izidore Lossos (Miami University)
Chapter 28. Regulation of the MYC oncogenic pathway by microRNAs - Prof. Marcos Malumbres (CNIO, Madrid, Spain)
Chapter 29. MicroRNA expression in cutaneous T-cell lymphomas ¬- Prof. Cornelius Tensen (Leiden University, Netherlands)
4.4 Other cancers
Chapter 30. Identification and function of aberrantly-expressed microRNAs in prostate cancer - Dr. M. Ozen (Yeditepe University Medical School, Istanbul, Turkey)
Chapter 31. MicroRNA signatures as biomarkers of colorectal cancer - Prof. Hermann Brenner- (German Cancer Research Center, Heidelberg, Germany)
Chapter 32. Glioma growth regulation by miR-10b ¬- Prof. Anna Krichevsky (Havard Medical School, Boston)

Section V: Circulating microRNAs: Novel non-invasive biomarkers
Chapter 33. Use of microRNAs as non-invasive pre-natal biomarkers ¬- Prof. Dennis Lo (University of Hong Kong)
Chapter 34. Circulating microRNAs as prognostic indicators of prostate cancer - Dr. Muneesh Tewari (Hutchinson Cancer Research Center, Seattle)
Chapter 35. Plasma microRNAs as indicators of heart disease - Prof. Naoharu Iwai (National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan)

Section VI: MicroRNAs as novel therapeutics
Chapter 36. MicroRNA as therapeutics - Prof. Philip Zamore (University of Massachusetts)
Chapter 37. miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44 - Prof. Dean Tang (M.D. Anderson Cancer Center, Texas)
Chapter 38. Therapeutic approaches based on metastasis-related miRNAs- Prof. Achim Aigner (Philipps-University, Marburg, Germany)
Chapter 39. Reconstitution of tumor suppressor microRNAs as cancer therapeutics- Dr Joshua Mendell (John Hopkins University, Baltimore)
Chapter 40. Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection - Dr Henrik Ørum (Santaris Pharma, Denmark)