Modern Organic Synthesis in the Laboratory

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  • Format: Paperback
  • Copyright: 2007-09-10
  • Publisher: Oxford University Press

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Searching for reaction in organic synthesis has been made much easier in the current age of computer databases. However, the dilemma now is which procedure one selects among the ocean of choices. Especially for novices in the laboratory, it becomes a daunting task to decide what reaction conditions to experiment with first in order to have the best chance of success. This collection intends to serve as an "older and wiser lab-mate" one could have by compiling many of the most commonly used experimental procedures in organic synthesis. With chapters that cover such topics as functional group manipulations, oxidation, reduction, and carbon-carbon bond formation, Modern Organic Synthesis in the Laboratory will be useful for both graduate students and professors in organic chemistry and medicinal chemists in the pharmaceutical and agrochemical industries.

Table of Contents

Forewordp. vii
Abbreviations and Acronymsp. xv
Fundamental Techniquesp. 3
Safety!p. 3
Useful Preparationsp. 5
Chromatographyp. 17
Crystallizationp. 22
Residual Solvent Peaks in Nuclear Magnetic Resonancep. 24
Functional Group Manipulationsp. 28
Alcohol Oxidation Statep. 28
Ketone Oxidation Statep. 39
Acid Oxidation Statep. 44
Oxidationp. 55
Alcohol to Ketone Oxidation Statep. 55
Alcohol to Acid Oxidation Statep. 68
Olefin to Diolp. 70
Aldehyde to Acid Oxidation Statep. 76
Heteroatom Oxidationsp. 78
Reductionsp. 81
Alcohols to Alkanesp. 81
Aldehydes, Amides, and Nitriles to Aminesp. 83
Carboxylic Acids and Derivatives to Alcoholsp. 85
Esters and Other Carboxylic Acid Derivatives to Aldehydesp. 88
Ketones or Aldehydes to Alcoholsp. 91
Ketones to Alkanes or Alkenesp. 98
Reductive Dehalogenationsp. 104
Carbon-Carbon Double and Triple Bond Reductionsp. 105
Heteroatom-Heteroatom Reductionsp. 108
Carbon-Carbon Bond Formationp. 111
Carbon-Carbon Forming Reactions (Single Bonds)p. 111
Carbon-Carbon Double Bonds (Olefin Formation)p. 150
Reactions that Form Multiple Carbon-Carbon Bondsp. 166
Protecting Groupsp. 168
Alcohols and Phenolsp. 168
Amines and Anilinesp. 176
Aldehydes and Ketonesp. 185
Indexp. 191
Table of Contents provided by Ingram. All Rights Reserved.

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