Molecular Genetics of Liver Neoplasia

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  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2010-11-08
  • Publisher: Springer Verlag

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Primary liver cancer is the third most deadly and fifth most common cancer worldwide (~500,000 deaths annually), with a sharp increase of incidence in the United States in recent years. Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) are the major types of primary liver cancer. Risk factors include gender, hepatitis B virus (HBV), hepatitis C virus (HCV), cirrhosis, metabolism diseases, diabetes, obesity, toxins, excess alcohol consumption and smoking. Liver cancer arises most frequently in inflammatory livers with extensive oxidative stress due to viral hepatitis which causes over 80% of HCC cases worldwide. Currently, survival remains dismal for most HCC and CC patients, largely due to the tumor's aggressiveness at the time of diagnosis and the lack of effective therapy.

Table of Contents

Biology of Hepatocellular Carcinoma: Past, Present and Beyondp. 3
Overview of Cholangiocarcinoma and Evidence for a Primary Liver Carcinoma Spectrump. 19
Liver Cancer Development and Pathogenesis
Pathology of Hepatocellular Carcinomap. 37
Genetics and Epidemiology of Liver Cancer
Epidemiology of Hepatocellular Carcinomap. 51
Genetics and Epidemiology of Cholangiocarcinomap. 75
Molecular Basis of Cancer Susceptibility
Signaling Pathways in Viral Related Pre-neoplastic Liver Disease and Hepatocellular Carcinomap. 103
Epigenetic Effects of Persistent Hepatitis C Virus Infection and Hepatocellular Carcinomap. 129
DNA Methylation Status in Chronic Liver Disease and Hepatocellular Carcinomap. 147
Animal Models
Transgenic and Knockout Mouse Models of Liver Cancerp. 163
Mosaic Cancer Mouse Models and Functional Oncogenomics in Hepatocellular Carcinomap. 189
The Zebrafish Model for Liver Carcinogenesisp. 197
Global Gene Expression Profiling of Human Liver Cancer
Integrative and Functional Genomics of HCCp. 221
Molecular Signatures of Hepatocellular Carcinoma Metastasisp. 241
Gene Mutations and Transcriptomic Profiles Associated to Specific Subtypes of Hepatocellular Tumorsp. 259
Cancer Stem Cells
Cancer Stem Cells and Liver Cancerp. 279
Heterogeneity of Liver Cancer Stem Cellsp. 301
Cancer Stem Cells in Liver Carcinomap. 319
Liver Cancer Genetics in the Clinic
Molecular Signaling in Hepatocellular Carcinomap. 337
Molecular Events on Metastasis of Hepatocellular Carcinomap. 349
Molecular Pathogenesis of Hepatocellular Carcinomap. 373
Subject Indexp. 397
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