Molecular Medical Parasitology

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  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2002-12-31
  • Publisher: Elsevier Science
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A valuable, new source, Molecular Medical Parasitology is the only text of its kind -- one that applies broad concepts and current scientific advances from both molecular biology and biochemistry to the study of parasitic organisms. An internationally renowned team of scientists and physicians places parasites in their broad biological contexts while still emphasizing the specifics that differentiate these organisms. Not only will researchers and faculty in parasitology find this an indispensable guide, physicians will benefit from the thorough coverage molecular biology and biochemistry's current influences on treatment and management of parasitic diseases. Key Features * Features the most up-to-date scientific methods behind the medical management of parasitic diseases * Applies the most current synthesis of molecular biology and biochemistry to parasitic organisms * Contains many informative figures and clear illustrations

Table of Contents

List of contributorsp. vii
Prefacep. xi
Molecular Biologyp. 1
Parasite genomicsp. 3
RNA processing in parasitic organisms: trans-splicing and RNA editingp. 29
Transcriptionp. 47
Post-transcriptional regulationp. 67
Antigenic variation in African trypanosomes and malariap. 89
Genetic and genomic approaches to the analysis of Leishmania virulencep. 111
Biochemistry and Cell Biology: Protozoap. 123
Energy metabolism
Anaerobic protozoap. 125
Aerobic protists - trypanosomatidaep. 140
Energy metabolism in the Apicomplexap. 154
Amino acid and protein metabolismp. 171
Purine and pyrimidine transport and metabolismp. 197
Trypanosomatid surface and secreted carbohydratesp. 225
Intracellular signalingp. 241
Plastids, mitochondria, and hydrogenosomesp. 277
Biochemistry and Cell Biology: Helminthsp. 295
Helminth surfaces: structural, molecular and functional propertiesp. 297
Carbohydrate and energy metabolism in parasitic helminthsp. 339
Neurotransmittersp. 359
Medical Applicationsp. 395
Drug resistance in parasitesp. 397
Medical implications of molecular parasitologyp. 433
Indexp. 463
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