Multiple Sclerosis Clinician's Guide to Diagnosis and Treatment

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  • Edition: 2nd
  • Format: Paperback
  • Copyright: 2013-05-01
  • Publisher: Oxford University Press

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Multiple Sclerosis (MS) is an inflammatory, often progressive, and potentially disabling disease of the central nervous system. Onset of disease is usually between the ages of 15 and 50, with the incidence nearly twice as high in women. While the cause of MS is still unknown, the predominant theory is that it is an autoimmune disease, triggered by an unknown environmental factor that results in both loss of central nervous system myelin and degeneration of axons and neurons. Although there have been a number of publications addressing different aspects of MS treatment in the neurological literature, there is a dearth of material on MS designed for internists and primary care physicians, who are often the first to see patients presenting with symptoms of MS. Therefore, this concise, clinically focused volume will serve as a valuable resource tailored to the specific needs of internists and primary care physicians. Part of the Oxford Neurology Library, this highly practical pocketbook covers current approaches and new developments in the diagnosis, treatment and management of MS, including both early and advanced stages of the disease. The book offers in-depth coverage of special populations, as well as the more unusual manifestations of MS, which are less familiar to the internal medicine audience. It will also address the role of imaging studies in the diagnosis, differential diagnosis and monitoring of the progression of MS. In addition to providing up-to-date information on pharmacological therapies for MS, the book also describes an array of non-pharmacological treatment options.

Table of Contents

A Brief History of Multiple Sclerosis
Experimental Autoimmune Encephalomyelitis
Factors Involved in Causing Multiple Sclerosis
Causes of MS
The Patterns and Pathophysiology of Multiple Sclerosis
Patterns of MS
Pathophysiology of MS
Imaging of the Central Nervous System in Multiple Sclerosis
Standard X-Ray Imaging of the Skull and Spinal Columns
Computed Tomography (CT) Imaging of the CNS
Magnetic Resonance Imaging
Making a Diagnosis of Multiple Sclerosis
Patterns of Disease Presentation
Genetics of MS
Initial Clinical Symptoms in Persons with Relapsing-Remitting MS
Initial Clinical Symptoms of Primary-Progressive MS
Presenting Signs in MS
Magnetic Resonance Imaging
Evoked Responses
Cerebrospinal Fluid Analysis
Ruling Out "MS Look-alikes"
Algorithms for the Diagnosis of MS
Imparting a Diagnosis of MS
Complications and Comorbidities of Multiple Sclerosis
Loss of Bone Density (Osteopenia or Osteoporosis)
Sleep Apnea and Other Altered Sleep Patterns
Mood Disturbances
Urinary Tract and Other Infections
Sexual Dysfunction
Skin Lesions
Joint Dysfunction
Relapses of Multiple Sclerosis and Their Treatment
What Constitutes a Relapse?
Conventional Relapse Treatments
Unconventional Relapse Treatments
Relapse Prevention
Long-Term Disease-Modifying Therapies
Issues with Long-Term Immune-Modulating Therapies
Glatiramer Acetate
Second-Line Disease-Modifying Therapies
When Should Long-Term Immune-Modulating Therapy Be Stopped?
Future Therapies
Management of Multiple Sclerosis Symptoms
Sexual Dysfunction
Complementary Therapies for Multiple Sclerosis
Physical Therapy
Exercise Physiologists
Occupational Therapy
Psychiatrists, Counselors, and Psychologists
Social Workers
Diet, Nutrition, and Food Supplements
Gender Issues and Special Multiple Sclerosis Populations
Children of Parents with MS
Pediatric MS
Web Sites
Patient Advocacy Organizations
Sites for Disease-Modifying Therapies
Site for MR Imaging Protocol for MS
Patient Books and Materials
Table of Contents provided by Publisher. All Rights Reserved.

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