Myasthenia Gravis and Related Disorders : Biochemical Basis for Disease of the Neuromuscular Junction

by ;
  • ISBN13:


  • ISBN10:


  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2003-11-01
  • Publisher: New York Academy of Sciences

Note: Supplemental materials are not guaranteed with Rental or Used book purchases.

Purchase Benefits

  • Free Shipping On Orders Over $35!
    Your order must be $35 or more to qualify for free economy shipping. Bulk sales, PO's, Marketplace items, eBooks and apparel do not qualify for this offer.
  • Get Rewarded for Ordering Your Textbooks! Enroll Now
List Price: $140.00 Save up to $35.00
  • Buy Used
    Add to Cart Free Shipping


Supplemental Materials

What is included with this book?

Table of Contents

Introduction xiii
Mark A. Agius
Part I. Structure and Function of the Neuromuscular Junction: Physiology and Neurotransmitter Release
Neurophysiology of the Neuromuscular Junction: Overview
Robert L. Ruff
Ca2+ Channels and Synaptic Transmission at the Adult, Neonatal, and P/Q-Type Deficient Neuromuscular Junction
Silvana Nudler
Joaquin Piriz
Francisco J. Urbano
Marcelo D. Rosato-Siri
Erika S. Piedras Renteria
Osvaldo D. Uchitel
Effect of Inherited Abnormalities of Calcium Regulation on Human Neuromuscular Transmission
Ricardo A. Maselli
Wendy Books
Vanessa Dunne
Transmitter Release Deficits at the Neuromuscular Synapse of Mice with Mutations in the Cav2.1 (1A) Subunit of the P/Q-Type Ca2+ Channel
J. J. Plomp
A. M. Van Den Maagdenberg
M. D. Ferrari
R. R. Frants
P. C. Molenaar
Protein Ubiquitylation and Synaptic Function
Ottavio Cremona
Chiara Collesi
Elisabetta Raiteri
Part II. Structure and Function of the Neuromuscular Junction: Structure and Function of the Acetylcholine Receptor
Nicotinic Acetylcholine Receptors of Muscles and Nerves: Comparison of Their Structures, Functional Roles and Vulnerability to Pathology
Jon M. Lindstrom
Synapse-Specific Gene Expression at the Neuromuscular Junction
Alexandre Mejat
Aymeric Ravel-Chapuis
Marie Vandromme
Laurent Schaeffer
Regulation of Nicotinic Acetylcholine Receptor Assembly
Christian P. Wanamaker
John C. Christianson
William N. Green
Structure and Function of AChBP, Homologue of the Ligand-Binding Domain of the Nicotinic Acetylcholine Receptor
August B. Smit
Katjusa Brejc
Naweed Syed
Titia K. Sixma
The Binding Site of Acetylcholine Receptor: From Synthetic Peptides to Solution and Crystal Structure
Sara Fuchs
Roni Kasher
Moshe Balass
Tali Scherf
Michal Harel
Mati Fridkin
Joel L. Sussman
Ephraim Katchalski-Katzir
Agonist-Induced Transitions of the Acetylcholine Receptor
Robert H. Fairclough
Mark A. Agius
Eswari Gudipati
Laura Silvian
Brent Hamaoka
Christopher C. Beltzner
Mike Y. Lin
Anthony R. Chuang
David P. Richman
Part III. Structure and Function of the Neuromuscular Junction: Genetic Biochemical Disorders
Structural Abnormalities of the AChR Caused by Mutations Underlying Congenital Myasthenic Syndromes
David Beeson
Richard Webster
John Ealing
Rebecca Croxen
Sharon Brownlow
Martin Brydson
John Newsom-Davis
Clarke Slater
Chris Hatton
Chris Shelley
David Colquhoun
Angela Vincent
Congenital Myasthenic Syndrome in Cattle due to Homozygosity for a Truncating Mutation in the Acetylcholine Receptor (AChR) Epsilon-Subunit Gene
Joern P. Sieb
Simone Kraner
Peter N. Thompson
Ortrud K. Steinlein
Mechanistic Diversity Underlying Fast Channel Congenital Myasthenic Syndromes
Steven M. Sine
Hai-Long Wang
Kinji Ohno
Xin-Ming Shen
Won Yong Lee
Andrew G. Engel
Congenital Myasthenic Syndromes: Multiple Molecular Targets at the Neuromuscular Junction
Andrew G. Engel
Kinji Ohno
Xin-Ming Shen
Steven M. Sine
Part IV. Autoimmunity: General Concepts
Autoimmune Diseases as the Loss of Active ``Self-Control''
Jean-Francois Bach
Immunology of Paraneoplastic Syndromes: Overview
Jerome B. Posner
Part V. Immunology of Autoimmune Disorders Involving the Neuron and Presynaptic Nerve Terminal
Pathogenic Autoantibodies in the Lambert-Eaton Myasthenic Syndrome
Bethan Lang
Ashwin Pinto
Federica Giovannini
John Newsom-Davis
Angela Vincent
LEMS IgG Binds to Extracellular Determinants on N-Type Voltage-Gated Calcium Channels, but Does Not Reduce VGCC Expression
Kazuo Iwasa
Ashwin Pinto
Angela Vincent
Bethan Lang
HLA-B8 in Patients with the Lambert-Eaton Myasthenic Syndrome Reduces Likelihood of Associated Small Cell Lung Carcinoma
Paul W. Wirtz
Nick Willcox
Bart O. Roep
Bethan Lang
Axel R. Wintzen
John Newsom-Davis
Jan J. Verschuuren
Autoimmune Disorders of Neuronal Potassium Channels
John Newsom-Davis
Camilla Buckley
Linda Clover
Ian Hart
Paul Maddison
Erdem Tuzum
Angela Vincent
Neuronal Ganglionic Acetylcholine Receptor Autoimmunity
Steven Vernino
Vanda A. Lennon
Humoral and Cellular Autoimmune Responses in Stiff Person Syndrome
Tobias Lohmann
Marco Londei
Mohammed Hawa
R. David G. Leslie
Part VI. Immunology of Postsynaptic Autoimmune Disorders: The Thymus
The Role of Thymomas in the Development of Myasthenia Gravis
Alexander Marx
Hans Konrad Muller-Hermelink
Philipp Strobel
Scenarios for Autoimmunization of T and B Cells in Myasthenia Gravis
H. Shiono
I. Roxanis
W. Zhang
G. P. Sims
A. Meager
L. W. Jacobson
J-L. Liu
I. Matthews
Y-L. Wong
M. Bonifati
K. Micklem
D. I. Stott
J. A. Todd
D. Beeson
A. Vincent
N. Willcox
A New Model Linking Intrathymic Acetylcholine Receptor Expression and the Pathogenesis of Myasthenia Gravis
Arnold I. Levinson
Yi Zheng
Glen Gaulton
Jonni Moore
C. Hank Pletcher
Decheng Song
Lisa M. Wheatley
Human Myoid Cells Protect Thymocytes from Apoptosis
Rozen Le Panse-Ruskone
Sonia Berrih-Aknin
Analysis of SjTREC Levels in Thymus from MG Patients and Normal Children
Laura Passerini
Pia Bernasconi
Fulvio Baggi
Ferdinando Cornelio
Renato Mantegazza
Analysis of CD4+CD25+ Cell Population in the Thymus from MG Patients
A. Balandina
A. Saoudi
Ph. Dartevelle
S. Berrih-Aknin
Expression of Transforming Growth Factor-1 in Thymus of Myasthenia Gravis Patients: Correlation with Pathological Abnormalities
Pia Bernasconi
Laura Passerini
Andrea Annoni
Federica Ubiali
Cristiana Marcozzi
Paolo Confalonieri
Ferdinando Cornelio
Rena To Mantegazza
Part VII. Immunology of Postsynaptic Autoimmune Disorders: T Cells and Immunoregulation
T Cells and Cytokines in the Pathogenesis of Acquired Myasthenia Gravis
Monica Milani
Norma Ostlie
Wei Wang
Bianca M. Conti-Fine
Immunoregulation in Experimental Autoimmune Myasthenia Gravis---about T Cells, Antibodies and Endplates
M. De Baets
M. Stassen
M. Losen
X. Zhang
B. Machiels
Circulating CD4+CD25+ and CD4+CD25- T Cells in Myasthenia Gravis
Y. Huang
R. Pirskanen
R. Ciscombe
H. Link
A-K. Lefvert
Rationale for a T Cell Receptor Peptide Therapy in Myasthenia Gravis
F. Jambou
M. Menestrier
I. Klingel-Schmitt
S. Caillat-Zucman
A. Aissaoui
S. Berrih-Aknin
S. Cohen-Kaminsky
Part VIII. Immunology of Postsynaptic Autoimmune Disorders: Antigenic Targets and Human Disease
Antibodies in Myasthenia Gravis and Related Disorders
Angela Vincent
John McConville
Maria Elena Farrugia
John Bowen
Paul Plested
Teresa Tang
Amelia Evoli
Ian Matthews
Gary Sims
Paola Dalton
Leslie Jacobson
Agata Polizzi
Frans Blaes
Bethan Lang
David Beeson
Nick Willcox
John Newsom-Davis
Werner Hoch
Differences between the ε and γ Subunits of the Acetylcholine Receptor (AChR) May Be Significant in Autoimmune Myasthenia Gravis
Samia Ragheb
Robert P. Lisak
Use of Peptide: HLA Class II Complexes to Study Specific T Cells in Autoimmune Myasthenia Gravis
Uday Kishore
Wei Zhang
Louise Corlett
Patrick Waters
Nicolas Glaichenhaus
Nick Willcox
Pathogenesis of Myositis and Myasthenia Associated with Titin and Ryanodine Receptor Antibodies
Geir Olve Skeie
Fredrik Romi
Johan A. Aarli
Pal Tore Bentsen
Nils Erik Gilhus
Antibodies in Sera of Patients with Late-Onset Myasthenia Gravis Recognize the PEVK Domain of Titin
Mirta Mihovilovic
Emma Ciafaloni
Jennifer Butter Worth-Robinette
Jian-Ping Jin
Janice Massey
Donald B. Sanders
Identification of Disease-Specific Autoantibodies in Seronegative Myasthenia Gravis
Emanuela Bartoccioni
Mariapaola Marino
Amelia Evoli
Marcus A. Ruegg
Flavia Scuderi
Carlo Provenzano
Muscle and Neuronal Autoantibody Markers of Thymoma: Neurological Correlations
Steven Vernino
Vanda A. Lennon
Susceptibility of Ocular Tissues to Autoimmune Diseases
Henry J. Kaminski
Zhuyi Li
Chelliah Richmonds
Robert L. Ruff
Linda Kusner
Part IX. Immunology of Postsynaptic Autoimmune Disorders: Antigenic Targets and Experimental Myasthenia
Induction of Myasthenia Gravis in HLA Transgenic Mice by Immunization with Human Acetylcholine Receptors
Huan Yang
Elzbieta Goluszko
Chella David
David K. Okita
Bianca Conti-Fine
Teh-Sheng Chan
Mathilde A. Poussin
Premkumar Christadoss
Production and Characterization of a T Cell Receptor Transgenic Mouse Recognizing the Immunodominant Epitope of the Torpedo californica Acetylcholine Receptor
Alexei Miagkov
Adrian A. Lobito
Bingzhi Yang
Marcela F. Lopes
Robert N. Adams
Gregory R. Palardy
Michele M. Johnson
Hugh I. McFarland
Michael J. Lenardo
Daniel B. Drachman
Epitope Repertoire of Th1 and Th2 Cells Reactive with the Mouse Muscle AChR α Subunit in C57B1/6 Mice
Wei Wang
Monica Milani
David Okita
Norma Ostlie
Bianca M. Conti-Fine
Epitope Spreading to Hidden Cytoplasmic Regions of the Acetylcholine Receptor in Experimental Autoimmune Myasthenia Gravis
Tali Feferman
Sin-Hyeog Im
Sara Fuchs
Miriam C. Souroujon
Immunization with Rat-, but Not Torpedo-Derived 97--116 Peptide of the AChR α-Subunit Induces Experimental Myasthenia Gravis (EAMG) in Lewis Rat
Fulvio Baggi
Andrea Annoni
Federica Ubiali
Renato Longhi
Monica Milani
Renato Mantegazza
Ferdinando Cornelio
Carlo Antozzi
Effect on T Cell Recognition and Immunogenicity of Alanine-Substituted Peptides Corresponding to 97--116 Sequence of the Rat AChR α-Subunit
Fulvio Baggi
Andrea Annoni
Federica Ubiali
Renato Longhi
Renato Mantegazza
Ferdinando Cornelio
Carlo Antozzi
Characterization of a Fully Human IgG1 Reconstructed from an Anti-AChR Fab
Maurice H. W. Stassen
Barbie M. Machiels
Efrosini Fostieri
Socrates J. Tzartos
Sonia Berrih-Aknin
Eugene Bosmans
Paul W. H. I. Parren
Marc H. De Baets
Roles of Complex Gangliosides at the Neuromuscular Junction
R. W. M. Bullens
G. M. O'Hanlon
E. Wagner
P. C. Molenaar
Koichi Furukawa
Keiko Furukawa
J. J. Plomp
H. J. Willison
Role of Munc 18-1 in Synaptic Plasticity at the Myasthenic Neuromuscular Junction
M. S. Sons
M. Verhage
J. J. Plomp
Part X. Epidemiology and Measurements in Myasthenia Gravis
The Epidemiology of Myasthenia Gravis
Lawrence H. Phillips II
Myasthenia Gravis (MG): Epidemiological Data and Prognostic Factors
Renato Mantegazza
Fulvio Baggi
Carlo Antozzi
Paolo Confalonieri
Lucia Morandi
Pia Bernasconi
Francesca Andreetta
Ornella Simoncini
Angela Campanella
Ettore Beghi
Ferdinando Cornelio
Myasthenia Gravis in Individuals over Forty
Johan A. Aarli
Fredrik Romi
Geir Olve Skeie
Nils Erik Gilhus
Standards of Measurements in Myasthenia Gravis
Richard J. Barohn
A Simple Manual Muscle Test for Myasthenia Gravis: Validation and Comparison with the QMG Score
Donald B. Sanders
Bernadette Tucker-Lipscomb
Janice M. Massey
Standards of Measurements in Myasthenia Gravis
P. Gajdos
T. Sharshar
S. Chevret
Part XI. Current Diagnosis and Treatment: Pre- and Postsynaptic Immune Syndromes
Three Forms of Immune Myasthenia
Mark A. Agius
David P. Richman
Robert H. Fairclough
Johan Aarli
Nils Erik Gilhus
Fredrik Romi
Treatment Principles in the Management of Autoimmune Myasthenia Gravis
David P. Richman
Mark A. Agius
Development of a Thymectomy Trial in Nonthymomatous Myasthenia Gravis Patients Receiving Immunosuppressive Therapy
Gil I. Wolfe
Henry J. Kaminski
Alfred Jaretzki III
Anthony Swan
John Newsom-Davis
Thymectomy and Antimuscle Antibodies in Nonthymomatous Myasthenia Gravis
Fredrik Romi
Nils E. Gilhus
Jan E. Varhaug
Andreas Myking
Geir O. Skeie
Johan A. Aarli
Prognostic Factors of Thymectomy in Patients with Myasthenia Gravis: A Cohort of 132 Patients
Jose Francisco Tellez-Zenteno
Jose Maria Remes-Troche
Guillermo Garcia-Ramos
Bruno Estanol
Juan Garduno-Espinoza
Mycophenolate Mofetil for Myasthenia Gravis: A Double-Blind, Placebo-Controlled, Pilot Study
Matthew N. Meriggioli
Julie Rowin
Judith G. Richman
Sue Leurgans
Lambert-Eaton Myasthenic Syndrome: Diagnosis and Treatment
Donald B. Sanders
Abnormal Single-Fiber Electromyography in Patients Not Having Myasthenia: Risk for Diagnostic Confusion?
Rudy Mercelis
Part XII. Future Therapies in Myasthenia
Treatment of Autoimmune Disease by Adoptive Cellular Gene Therapy
Ingo H. Tarner
Anthony J. Slavin
Jacqueline McBride
Alenka Levicnik
Richard Smith
Garry P. Nolan
Christopher H. Contag
C. Garrison Fathman
Specific Immunotherapy of Experimental Myasthenia by Genetically Engineered APCs: The ``Guided Missile'' Strategy
D. B. Drachman
J-M. Wu
A. Miagkov
M. A. Williams
R. N. Adams
B. Wu
Suppression of Myasthenia Gravis by Antigen-Specific Mucosal Tolerance and Modulation of Cytokines and Costimulatory Factors
Miriam C. Souroujon
Prasanta K. Maiti
Tali Feferman
Sin-Hyeog Im
Lily Raveh
Sara Fuchs
Suppression of EAMG in Lewis Rats by IL-10-Exposed Dendritic Cells
H. Link
Y. Huang
B. Xiao
Future Therapeutic Strategies in Autoimmune Myasthenia Gravis
Loukia Psaridi-Linardaki
Avgi Mamalaki
Socrates J. Tzartos
Index of Contributors 549

Rewards Program

Write a Review