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9781573313971

Myasthenia Gravis and Related Disorders : Biochemical Basis for Disease of the Neuromuscular Junction

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  • ISBN13:

    9781573313971

  • ISBN10:

    1573313971

  • Format: Paperback
  • Copyright: 2003-09-01
  • Publisher: New York Academy of Sciences

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Table of Contents

Introduction xiii
Mark A. Agius
Part I. Structure and Function of the Neuromuscular Junction: Physiology and Neurotransmitter Release
Neurophysiology of the Neuromuscular Junction: Overview
1(10)
Robert L. Ruff
Ca2+ Channels and Synaptic Transmission at the Adult, Neonatal, and P/Q-Type Deficient Neuromuscular Junction
11(7)
Silvana Nudler
Joaquin Piriz
Francisco J. Urbano
Marcelo D. Rosato-Siri
Erika S. Piedras Renteria
Osvaldo D. Uchitel
Effect of Inherited Abnormalities of Calcium Regulation on Human Neuromuscular Transmission
18(11)
Ricardo A. Maselli
Wendy Books
Vanessa Dunne
Transmitter Release Deficits at the Neuromuscular Synapse of Mice with Mutations in the Cav2.1 (1A) Subunit of the P/Q-Type Ca2+ Channel
29(4)
J. J. Plomp
A. M. Van Den Maagdenberg
M. D. Ferrari
R. R. Frants
P. C. Molenaar
Protein Ubiquitylation and Synaptic Function
33(8)
Ottavio Cremona
Chiara Collesi
Elisabetta Raiteri
Part II. Structure and Function of the Neuromuscular Junction: Structure and Function of the Acetylcholine Receptor
Nicotinic Acetylcholine Receptors of Muscles and Nerves: Comparison of Their Structures, Functional Roles and Vulnerability to Pathology
41(12)
Jon M. Lindstrom
Synapse-Specific Gene Expression at the Neuromuscular Junction
53(13)
Alexandre Mejat
Aymeric Ravel-Chapuis
Marie Vandromme
Laurent Schaeffer
Regulation of Nicotinic Acetylcholine Receptor Assembly
66(15)
Christian P. Wanamaker
John C. Christianson
William N. Green
Structure and Function of AChBP, Homologue of the Ligand-Binding Domain of the Nicotinic Acetylcholine Receptor
81(12)
August B. Smit
Katjusa Brejc
Naweed Syed
Titia K. Sixma
The Binding Site of Acetylcholine Receptor: From Synthetic Peptides to Solution and Crystal Structure
93(8)
Sara Fuchs
Roni Kasher
Moshe Balass
Tali Scherf
Michal Harel
Mati Fridkin
Joel L. Sussman
Ephraim Katchalski-Katzir
Agonist-Induced Transitions of the Acetylcholine Receptor
101(13)
Robert H. Fairclough
Mark A. Agius
Eswari Gudipati
Laura Silvian
Brent Hamaoka
Christopher C. Beltzner
Mike Y. Lin
Anthony R. Chuang
David P. Richman
Part III. Structure and Function of the Neuromuscular Junction: Genetic Biochemical Disorders
Structural Abnormalities of the AChR Caused by Mutations Underlying Congenital Myasthenic Syndromes
114(11)
David Beeson
Richard Webster
John Ealing
Rebecca Croxen
Sharon Brownlow
Martin Brydson
John Newsom-Davis
Clarke Slater
Chris Hatton
Chris Shelley
David Colquhoun
Angela Vincent
Congenital Myasthenic Syndrome in Cattle due to Homozygosity for a Truncating Mutation in the Acetylcholine Receptor (AChR) Epsilon-Subunit Gene
125(3)
Joern P. Sieb
Simone Kraner
Peter N. Thompson
Ortrud K. Steinlein
Mechanistic Diversity Underlying Fast Channel Congenital Myasthenic Syndromes
128(10)
Steven M. Sine
Hai-Long Wang
Kinji Ohno
Xin-Ming Shen
Won Yong Lee
Andrew G. Engel
Congenital Myasthenic Syndromes: Multiple Molecular Targets at the Neuromuscular Junction
138(23)
Andrew G. Engel
Kinji Ohno
Xin-Ming Shen
Steven M. Sine
Part IV. Autoimmunity: General Concepts
Autoimmune Diseases as the Loss of Active ``Self-Control''
161(17)
Jean-Francois Bach
Immunology of Paraneoplastic Syndromes: Overview
178(9)
Jerome B. Posner
Part V. Immunology of Autoimmune Disorders Involving the Neuron and Presynaptic Nerve Terminal
Pathogenic Autoantibodies in the Lambert-Eaton Myasthenic Syndrome
187(9)
Bethan Lang
Ashwin Pinto
Federica Giovannini
John Newsom-Davis
Angela Vincent
LEMS IgG Binds to Extracellular Determinants on N-Type Voltage-Gated Calcium Channels, but Does Not Reduce VGCC Expression
196(4)
Kazuo Iwasa
Ashwin Pinto
Angela Vincent
Bethan Lang
HLA-B8 in Patients with the Lambert-Eaton Myasthenic Syndrome Reduces Likelihood of Associated Small Cell Lung Carcinoma
200(2)
Paul W. Wirtz
Nick Willcox
Bart O. Roep
Bethan Lang
Axel R. Wintzen
John Newsom-Davis
Jan J. Verschuuren
Autoimmune Disorders of Neuronal Potassium Channels
202(9)
John Newsom-Davis
Camilla Buckley
Linda Clover
Ian Hart
Paul Maddison
Erdem Tuzum
Angela Vincent
Neuronal Ganglionic Acetylcholine Receptor Autoimmunity
211(4)
Steven Vernino
Vanda A. Lennon
Humoral and Cellular Autoimmune Responses in Stiff Person Syndrome
215(8)
Tobias Lohmann
Marco Londei
Mohammed Hawa
R. David G. Leslie
Part VI. Immunology of Postsynaptic Autoimmune Disorders: The Thymus
The Role of Thymomas in the Development of Myasthenia Gravis
223(14)
Alexander Marx
Hans Konrad Muller-Hermelink
Philipp Strobel
Scenarios for Autoimmunization of T and B Cells in Myasthenia Gravis
237(20)
H. Shiono
I. Roxanis
W. Zhang
G. P. Sims
A. Meager
L. W. Jacobson
J-L. Liu
I. Matthews
Y-L. Wong
M. Bonifati
K. Micklem
D. I. Stott
J. A. Todd
D. Beeson
A. Vincent
N. Willcox
A New Model Linking Intrathymic Acetylcholine Receptor Expression and the Pathogenesis of Myasthenia Gravis
257(9)
Arnold I. Levinson
Yi Zheng
Glen Gaulton
Jonni Moore
C. Hank Pletcher
Decheng Song
Lisa M. Wheatley
Human Myoid Cells Protect Thymocytes from Apoptosis
266(4)
Rozen Le Panse-Ruskone
Sonia Berrih-Aknin
Analysis of SjTREC Levels in Thymus from MG Patients and Normal Children
270(5)
Laura Passerini
Pia Bernasconi
Fulvio Baggi
Ferdinando Cornelio
Renato Mantegazza
Analysis of CD4+CD25+ Cell Population in the Thymus from MG Patients
275(3)
A. Balandina
A. Saoudi
Ph. Dartevelle
S. Berrih-Aknin
Expression of Transforming Growth Factor-1 in Thymus of Myasthenia Gravis Patients: Correlation with Pathological Abnormalities
278(6)
Pia Bernasconi
Laura Passerini
Andrea Annoni
Federica Ubiali
Cristiana Marcozzi
Paolo Confalonieri
Ferdinando Cornelio
Rena To Mantegazza
Part VII. Immunology of Postsynaptic Autoimmune Disorders: T Cells and Immunoregulation
T Cells and Cytokines in the Pathogenesis of Acquired Myasthenia Gravis
284(24)
Monica Milani
Norma Ostlie
Wei Wang
Bianca M. Conti-Fine
Immunoregulation in Experimental Autoimmune Myasthenia Gravis---about T Cells, Antibodies and Endplates
308(10)
M. De Baets
M. Stassen
M. Losen
X. Zhang
B. Machiels
Circulating CD4+CD25+ and CD4+CD25- T Cells in Myasthenia Gravis
318(2)
Y. Huang
R. Pirskanen
R. Ciscombe
H. Link
A-K. Lefvert
Rationale for a T Cell Receptor Peptide Therapy in Myasthenia Gravis
320(4)
F. Jambou
M. Menestrier
I. Klingel-Schmitt
S. Caillat-Zucman
A. Aissaoui
S. Berrih-Aknin
S. Cohen-Kaminsky
Part VIII. Immunology of Postsynaptic Autoimmune Disorders: Antigenic Targets and Human Disease
Antibodies in Myasthenia Gravis and Related Disorders
324(12)
Angela Vincent
John McConville
Maria Elena Farrugia
John Bowen
Paul Plested
Teresa Tang
Amelia Evoli
Ian Matthews
Gary Sims
Paola Dalton
Leslie Jacobson
Agata Polizzi
Frans Blaes
Bethan Lang
David Beeson
Nick Willcox
John Newsom-Davis
Werner Hoch
Differences between the ε and γ Subunits of the Acetylcholine Receptor (AChR) May Be Significant in Autoimmune Myasthenia Gravis
336(3)
Samia Ragheb
Robert P. Lisak
Use of Peptide: HLA Class II Complexes to Study Specific T Cells in Autoimmune Myasthenia Gravis
339(4)
Uday Kishore
Wei Zhang
Louise Corlett
Patrick Waters
Nicolas Glaichenhaus
Nick Willcox
Pathogenesis of Myositis and Myasthenia Associated with Titin and Ryanodine Receptor Antibodies
343(8)
Geir Olve Skeie
Fredrik Romi
Johan A. Aarli
Pal Tore Bentsen
Nils Erik Gilhus
Antibodies in Sera of Patients with Late-Onset Myasthenia Gravis Recognize the PEVK Domain of Titin
351(5)
Mirta Mihovilovic
Emma Ciafaloni
Jennifer Butter Worth-Robinette
Jian-Ping Jin
Janice Massey
Donald B. Sanders
Identification of Disease-Specific Autoantibodies in Seronegative Myasthenia Gravis
356(3)
Emanuela Bartoccioni
Mariapaola Marino
Amelia Evoli
Marcus A. Ruegg
Flavia Scuderi
Carlo Provenzano
Muscle and Neuronal Autoantibody Markers of Thymoma: Neurological Correlations
359(3)
Steven Vernino
Vanda A. Lennon
Susceptibility of Ocular Tissues to Autoimmune Diseases
362(13)
Henry J. Kaminski
Zhuyi Li
Chelliah Richmonds
Robert L. Ruff
Linda Kusner
Part IX. Immunology of Postsynaptic Autoimmune Disorders: Antigenic Targets and Experimental Myasthenia
Induction of Myasthenia Gravis in HLA Transgenic Mice by Immunization with Human Acetylcholine Receptors
375(4)
Huan Yang
Elzbieta Goluszko
Chella David
David K. Okita
Bianca Conti-Fine
Teh-Sheng Chan
Mathilde A. Poussin
Premkumar Christadoss
Production and Characterization of a T Cell Receptor Transgenic Mouse Recognizing the Immunodominant Epitope of the Torpedo californica Acetylcholine Receptor
379(5)
Alexei Miagkov
Adrian A. Lobito
Bingzhi Yang
Marcela F. Lopes
Robert N. Adams
Gregory R. Palardy
Michele M. Johnson
Hugh I. McFarland
Michael J. Lenardo
Daniel B. Drachman
Epitope Repertoire of Th1 and Th2 Cells Reactive with the Mouse Muscle AChR α Subunit in C57B1/6 Mice
384(4)
Wei Wang
Monica Milani
David Okita
Norma Ostlie
Bianca M. Conti-Fine
Epitope Spreading to Hidden Cytoplasmic Regions of the Acetylcholine Receptor in Experimental Autoimmune Myasthenia Gravis
388(3)
Tali Feferman
Sin-Hyeog Im
Sara Fuchs
Miriam C. Souroujon
Immunization with Rat-, but Not Torpedo-Derived 97--116 Peptide of the AChR α-Subunit Induces Experimental Myasthenia Gravis (EAMG) in Lewis Rat
391(4)
Fulvio Baggi
Andrea Annoni
Federica Ubiali
Renato Longhi
Monica Milani
Renato Mantegazza
Ferdinando Cornelio
Carlo Antozzi
Effect on T Cell Recognition and Immunogenicity of Alanine-Substituted Peptides Corresponding to 97--116 Sequence of the Rat AChR α-Subunit
395(4)
Fulvio Baggi
Andrea Annoni
Federica Ubiali
Renato Longhi
Renato Mantegazza
Ferdinando Cornelio
Carlo Antozzi
Characterization of a Fully Human IgG1 Reconstructed from an Anti-AChR Fab
399(2)
Maurice H. W. Stassen
Barbie M. Machiels
Efrosini Fostieri
Socrates J. Tzartos
Sonia Berrih-Aknin
Eugene Bosmans
Paul W. H. I. Parren
Marc H. De Baets
Roles of Complex Gangliosides at the Neuromuscular Junction
401(3)
R. W. M. Bullens
G. M. O'Hanlon
E. Wagner
P. C. Molenaar
Koichi Furukawa
Keiko Furukawa
J. J. Plomp
H. J. Willison
Role of Munc 18-1 in Synaptic Plasticity at the Myasthenic Neuromuscular Junction
404(3)
M. S. Sons
M. Verhage
J. J. Plomp
Part X. Epidemiology and Measurements in Myasthenia Gravis
The Epidemiology of Myasthenia Gravis
407(6)
Lawrence H. Phillips II
Myasthenia Gravis (MG): Epidemiological Data and Prognostic Factors
413(11)
Renato Mantegazza
Fulvio Baggi
Carlo Antozzi
Paolo Confalonieri
Lucia Morandi
Pia Bernasconi
Francesca Andreetta
Ornella Simoncini
Angela Campanella
Ettore Beghi
Ferdinando Cornelio
Myasthenia Gravis in Individuals over Forty
424(8)
Johan A. Aarli
Fredrik Romi
Geir Olve Skeie
Nils Erik Gilhus
Standards of Measurements in Myasthenia Gravis
432(8)
Richard J. Barohn
A Simple Manual Muscle Test for Myasthenia Gravis: Validation and Comparison with the QMG Score
440(5)
Donald B. Sanders
Bernadette Tucker-Lipscomb
Janice M. Massey
Standards of Measurements in Myasthenia Gravis
445(8)
P. Gajdos
T. Sharshar
S. Chevret
Part XI. Current Diagnosis and Treatment: Pre- and Postsynaptic Immune Syndromes
Three Forms of Immune Myasthenia
453(4)
Mark A. Agius
David P. Richman
Robert H. Fairclough
Johan Aarli
Nils Erik Gilhus
Fredrik Romi
Treatment Principles in the Management of Autoimmune Myasthenia Gravis
457(16)
David P. Richman
Mark A. Agius
Development of a Thymectomy Trial in Nonthymomatous Myasthenia Gravis Patients Receiving Immunosuppressive Therapy
473(8)
Gil I. Wolfe
Henry J. Kaminski
Alfred Jaretzki III
Anthony Swan
John Newsom-Davis
Thymectomy and Antimuscle Antibodies in Nonthymomatous Myasthenia Gravis
481(10)
Fredrik Romi
Nils E. Gilhus
Jan E. Varhaug
Andreas Myking
Geir O. Skeie
Johan A. Aarli
Prognostic Factors of Thymectomy in Patients with Myasthenia Gravis: A Cohort of 132 Patients
491(3)
Jose Francisco Tellez-Zenteno
Jose Maria Remes-Troche
Guillermo Garcia-Ramos
Bruno Estanol
Juan Garduno-Espinoza
Mycophenolate Mofetil for Myasthenia Gravis: A Double-Blind, Placebo-Controlled, Pilot Study
494(6)
Matthew N. Meriggioli
Julie Rowin
Judith G. Richman
Sue Leurgans
Lambert-Eaton Myasthenic Syndrome: Diagnosis and Treatment
500(9)
Donald B. Sanders
Abnormal Single-Fiber Electromyography in Patients Not Having Myasthenia: Risk for Diagnostic Confusion?
509(3)
Rudy Mercelis
Part XII. Future Therapies in Myasthenia
Treatment of Autoimmune Disease by Adoptive Cellular Gene Therapy
512(8)
Ingo H. Tarner
Anthony J. Slavin
Jacqueline McBride
Alenka Levicnik
Richard Smith
Garry P. Nolan
Christopher H. Contag
C. Garrison Fathman
Specific Immunotherapy of Experimental Myasthenia by Genetically Engineered APCs: The ``Guided Missile'' Strategy
520(13)
D. B. Drachman
J-M. Wu
A. Miagkov
M. A. Williams
R. N. Adams
B. Wu
Suppression of Myasthenia Gravis by Antigen-Specific Mucosal Tolerance and Modulation of Cytokines and Costimulatory Factors
533(4)
Miriam C. Souroujon
Prasanta K. Maiti
Tali Feferman
Sin-Hyeog Im
Lily Raveh
Sara Fuchs
Suppression of EAMG in Lewis Rats by IL-10-Exposed Dendritic Cells
537(2)
H. Link
Y. Huang
B. Xiao
Future Therapeutic Strategies in Autoimmune Myasthenia Gravis
539(10)
Loukia Psaridi-Linardaki
Avgi Mamalaki
Socrates J. Tzartos
Index of Contributors 549

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