Myofibrillogenesis

by Dube, Dipak K.; Markwald, Roger R.

• ISBN13: 9780817642266
• ISBN10: 0817642269
• Format: Hardcover
• Copyright: 2001-11-01
• Publisher: Birkhauser

Summary

Myofibrillogenesis has been studied extensively over the last 100 years. Until recently, we have not had a comprehensive understanding of this fundamental process. The emergence of new technologies in molecular and cellular biology, combined with classical embryology, have started to unravel some of the complexities of myofibril assembly in striated muscles. In striated muscles, the contractile proteins are arranged in a highly ordered three dimensional lattice known as the sarcomere. The assembly of a myofibril involves the precise ordering of several proteins into a linear array of sarcomeres. Multiple isoforms in many of these proteins further complicate the process, making it difficult to define the precise role of each component. This volume has been compiled as a comprehensive reference on myofibrillogenesis. In addition, the book includes reviews on myofibrillar disarray under various pathological conditions, such as familial hypertrophic cardiomyopathy (FHC), and incorporates a section on the conduction system in the heart. Much of the information in this volume has not been described elsewhere. Presented in a manner to be of value to students and teachers alike, "Myofibrillogenesis" will be an invaluable reference source for all in the fields of muscle biology and heart development.

Table of Contents

Contributors	vii
Series Preface	xi
Roger R. Markwald
Foreword	xiii
Roger R. Markwald
Preface	xv
PART I: ASSEMBLY OF MYOFIBRILLAR PROTEINS IN STRIATED MUSCLE	1	(70)
Myofibrillogenesis in Cardiac Muscle	3	(18)
Joseph W. Sanger
Jean M. Sanger
Dynamics of Contractile Proteins Constituting Myofibrils in Living Muscle Cells	21	(20)
Yutaka Shimada
Tin Moe Nwe
Fukuko Hasebe-Kishi
Homare Suzuki
Emergence of the First Myofibrils and Targeting Mechanisms Directing Sarcomere Assembly in Developing Cardiomyocytes	41	(18)
Elisabeth Ehler
Jean-Claude Perriard
Tropomodulin: An Important Player in Cardiac Myofibrillogenesis	59	(12)
Catherine McLellan
Carol C. Gregorio
PART II: MAINTENANCE AND MANIPULATION OF MYOFIBRILLAR ORGANIZATION	71	(30)
Maintaining the Fully Differentiated Cardiac Sarcomere	73	(14)
Daniel E. Michele
Joseph M. Metzger
Manipulation of Myofibrillogenesis in Whole Hearts	87	(14)
Robert W. Zajdel
Matthew D. McLean
Christopher R. Denz
Syamalima Dube
Larry F. Lemanski
Dipak K. Dube
PART III: REGULATION OF EXPRESSION OF MYOFIBRILLAR PROTEINS	101	(78)
Molecular Regulation of Cardiac Myofibrillogenesis: Roles of Serum Response Factor, Nkx2-5, and GATA-4	103	(26)
Robert J. Schwartz
Jorge Sepulveda
Narasimhaswamy S. Belaguli
Regulation and Organization of Human Troponin Genes	129	(14)
Paul J.R. Barton
Kimberley A. Dellow
Pankaj K. Bhavsar
Martin E. Cullen
Antony J. Mullen
Nigel J. Brand
Signal Transduction in Myofibrillogenesis, Cell Growth, and Hypertrophy	143	(10)
M.A.Q. Siddiqui
Michael Wagner
Eduardo Mascareno
Saiyid Shafiq
Cytoskeletal Gene Expression in the Developing Cardiac Conduction System	153	(26)
Robert E. Welikson
Takashi Mikawa
PART IV: HEART DEVELOPMENT AND MYOFIBRILLAR ORGANIZATION	179	(44)
Onset of a Cardiac Phenotype in the Early Embryo	181	(26)
Leonard M. Eisenberg
Carol A. Eisenberg
Cellular, Molecular, and Developmental Studies on Heart Development in Normal and Cardiac Mutant Axolotls, Ambystoma mexicanum	207	(16)
Larry F. Lemanski
Xupei Huang
Robert W. Zajdel
Sharon L. Lemanski
Chi Zhang
Fanyin Meng
Dalton Foster
Qing Li
Dipak K. Dube
PART V: CARDIOMYOPATHY AND MYOFIBRILLAR ORGANIZATION	223	(42)
The Function of Normal and Familial Hypertrophic Cardiomyopathy-Associated Tropomyosin	225	(12)
Rethinasamy Prabhakar
Kathy Pieples
Ganapathy Jagatheesan
Stephanie Burge
David F. Wieczorek
Cardiomyopathies and Myofibril Abnormalities	237	(28)
Jeffrey A. Towbin
Neil E. Bowles
Index	265