Neglected Factors in Pharmacology and Neuroscience Research: Biopharmaceutics, Animal Characteristics, Maintenance, Testing Conditions

by Claassen, Volkert

• ISBN13: 9780444818713
• ISBN10: 0444818715
• Format: Hardcover
• Copyright: 1994-09-01
• Publisher: Elsevier Science Ltd

Summary

The objective of this book is to indicate those variables which in gen eral may need a better control. Examples, gathered from the literature , are presented to illustrate the impact that those neglected variable s may have on various characteristics. The book presents a series of r epresentative studies from a broad field of interest so that insight c an be obtained about the potential effects of these parameters in expe riemental outcome. In this way, an impetus should be given to the crit ical consideration of test design and limitations of conclusions from experimental results.

Table of Contents

Introduction: reproducibility of animal experiments	p. 1
Biopharmaceutics	p. 3
Intravenous drug administration	p. 5
Intramuscular drug administration	p. 23
Subcutaneous drug administration	p. 35
Intraperitoneal drug administration	p. 46
Oral drug administration	p. 59
Animal Characteristics	p. 117
Inbred strains and outbred stocks	p. 119
Male - female differences	p. 154
Changes during development and aging	p. 184
Maintenance of Experimental Animals	p. 223
Housing conditions	p. 225
Food composition	p. 251
Food and water intake	p. 267
Testing Conditions	p. 289
Fasting	p. 290
Food restriction	p. 321
Circadian and other rhythms	p. 343
Anaesthesia	p. 382
Stress	p. 422
Import of Experimental Results	p. 461
Index	p. 471
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