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  • Edition: 3rd
  • Format: Hardcover
  • Copyright: 2012-12-28
  • Publisher: Oxford University Press

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Neuroglia, the third edition, is the long-awaited revision of the most highly regarded reference volume on glial cells. This indispensable edition has been completely revised, greatly enlarged, and enhanced with four-color figures throughout, all in response to the tremendous amount of new information that has accumulated since the previous edition seven years ago. Glial cells are, without doubt, the new stars in the neuroscience and neurology communities. Neglected in research for years, it is now evident that the brain only functions in a concerted action of all the cells, namely glia and neurons. Seventy one chapters comprehensively discuss virtually every aspect of normal glial cell anatomy, physiology, biochemistry and function, and consider the central roles of these cells in neurological diseases including stroke, Alzheimer disease, multiple sclerosis, Parkinson's disease, neuropathy, and psychiatric conditions. More than 20 new chapters have been added to accommodate the unprecedented growth of knowledge about the basic biology of glia and the sophisticated manner in which they partner with neurons in the course of normal brain function. Lavishly illustrated and meticulously edited, the third edition remains the most convenient and maximally useful reference available. This new edition is an essential reference for both newcomers to the field as well as established investigators. Neuroglia belongs on every neuroscientist's bookshelf and will be a great asset for educators and neurological clinicians as well.

Author Biography

Helmut Kettenmann, PhD, Research Group Leader, Cellular Neurosciences, Max-Delbrück-Centrum for Molecular Neuroscience, Berlin, Germany.

Bruce R. Ransom, MD, PhD, Warren and Jermaine Magnuson Professor and Chair, Department of Neurology, University of Washington School of Medicine, Seattle, WA

Table of Contents

Foreword to Ed. 3Introduction
Properties of Neuroglial Cells
Evolution of glial cells: insights from invertebrate glia
Evolution of glial cells
Invertebrate glia
Non-mammalian, vertebrate glia
Morphology, Ultrastructure and Identification
Astrocyctes and Ependymal Glia
Radial glial cells
Structure and Function of Oligodendrocytes
Schwann cells and myelin
Microglial Cells
Pericytes of the central nervous system
NG2 Cells (Polydendrocytes)
Glial Cells in autonomic and sensory ganglia
Lineage and development
Astrocyte Development
Lineage and development: Oligodendrocytes
The Schwann Cell Lineage: Cellular Transitions During Development and After Injury
Microglia Lineage and Development
Physiological Properties
Physiology of astrocytes: Ion channels and ion transporters
Release of gliotransmitters and transmitter receptors in astrocytes
Storage and release of non-transmitter signaling molecules from macroglia
Physiology of microglia
Physiology of Oligodendrocytes
Physiological Properties of NG2+ Glial Cells
Cytokine, chemokine and growth factor receptors and signaling
Lipids, lipid mediators and other signaling molecules
Gap Junctions and Hemichannels
Purinergic Mechanisms in Glial Cells
Calcium signalling in neuroglia
The Central Role of Astrocytes in Neuroenergetics
Genomic Profiles
The Astrocyte Transcriptome
Gene expression patterns of oligodendrocyte progenitor cells and oligodendroglia
Functions of Neuroglial Cells
Outer Subventricular Zone Radial Glial Cells
Glial control of synaptogenesis
Neuron Migration and Axon Guidance
The Role of Glia in the Formation and Function of the Blood-Brain Barrier
Control of the extracellular ionic environment and volume
Amino Acid Neurotransmitter Synthesis and Removal
Glycogen and Energy Metabolism
Astrocyte regulation of neurovascular control
Modulation of synaptic function and network activity
Astrocytic modulation of mammalian synapses circuits and behaviors
Adult neurogenesis
Modulation of neuroendocrine systems
Oligodendrocytes/Schwann cells
Myelin, Impulse Conduction, and the Pathophysiology of Demyelination
Transcription factors in myelinating cells
Factors controlling myelin formation
Regulation of Myelination by Functional Activity
Iron and Glia
Role of microglia in the normal brain
Factors controlling microglial activation
Roles of activated microglia
Immune functions of microglia
Role of glial cells in disease
Mechanisms of glial injury
Astrocyte Responses to CNS Injury and Disease
Metabolic injury of oligodendrocytes and myelin
Interaction of microglia with neurons and astrocytes under lesioned neuronal conditions
Schwann cells and injury
Recovery of Neural Function
Nerve Regeneration in the Peripheral Nervous System
Nerve fibre regeneration in the CNS of higher vertebrates
Glial Cell Transplantation for CNS Repair
Focal cerebral ischemia: The multifaceted role of glial cells
Malignant Glioma
Glial tumors in Neurofibromatosis and Tuberous Sclerosis Complex
Demyelinating diseases
Multiple Sclerosis
Genetic mutations affecting myelin formation
Neurodegenerative Diseases
Amyotrophic Lateral Sclerosis (ALS)
Alzheimer's disease
Huntington disease, Parkinson disease and other neurodegenerative diseases
Infectious diseases
Glia in Bacterial and Viral CNS Infections
Miscellaneous diseases
Neuroglia in Hepatic Encephalopathy
Microglia and Pain
Genetic disorders affecting astrocytes
Psychiatric Disorders
Table of Contents provided by Publisher. All Rights Reserved.

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