Neuroimaging in Developmental Clinical Neuroscience

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  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2009-03-23
  • Publisher: Cambridge University Press

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Modern neuroimaging offers tremendous opportunities for gaining insights into normative development and a wide array of developmental neuropsychiatric disorders. Focusing on ontogeny, this text covers basic processes involved in both healthy and atypical maturation, and also addresses the range of neuroimaging techniques most widely used for studying children. This book will enable you to understand normative structural and functional brain maturation and the mechanisms underlying basic developmental processes; become familiar with current knowledge and hypotheses concerning the neural bases of developmental neuropsychiatric disorders; and learn about neuroimaging techniques, including their unique strengths and limitations. Coverage includes normal developmental processes, atypical processing in developmental neuropsychiatric disorders, ethical issues, neuroimaging techniques and their integration with psychopharmacologic and molecular genetic research approaches, and future directions. This comprehensive volume is an essential resource for neurologists, neuropsychologists, psychiatrists, pediatricians, and radiologists concerned with normal development and developmental neuropsychiatric disorders.

Table of Contents

List of Contributorsp. vii
Forewordp. xiii
Prefacep. xvii
p. 1
Introduction to Section 1p. 3
Morphological development of the brain: what has imaging told us?p. 5
Neural correlates of the development of cognitive controlp. 22
Neurobiology of emotion regulation in children and adultsp. 38
Goal-directed behavior: evolution and ontogenyp. 53
Charting brain mechanisms for the development of social cognition Kevin A. Pelphreyp. 73
Language and the developing brain: insights from neuroimaging Kristin McNealy, Mirella Dapretto and Susan Bookheimerp. 91
Atypical processes in developmental neuropsychiatric disordersp. 109
Introduction to Section 2p. 111
A pathophysiology of attention deficit/hyperactivity disorder: clues from neuroimagingp. 113
Brain imaging of autism spectrum disordersp. 130
Neuroimaging of schizophrenia and its developmentp. 147
Cortico-limbic development in bipolar disorder: a neuroimaging viewp. 161
Anxiety and depressive disordersp. 183
Disturbances of fronto-striatal circuits in Tourette syndrome and obsessive-compulsive disorderp. 199
From genes to brain to behavior: the case of fragile X syndromep. 217
Alcohol exposure and the developing human brain James M. Bjorkp. 229
Neuroimaging as a tool for unlocking developmental pathophysiology in anorexia and bulimia nervosap. 245
Ethical issuesp. 259
Introduction to Section 3p. 261
Legal and ethical considerations in pediatric neuroimaging researchp. 263
Techniques and integration with other research approachesp. 277
Introduction to Section 4p. 279
Bold fMRI: an update with emphasis on pediatric applicationsp. 281
Magnetic resonance spectroscopy: methods and applications in developmental clinical neurosciencep. 296
Diffusion tensor imaging in developmental clinical neurosciencep. 314
Arterial spin labeling perfusion magnetic resonance imaging in developmental neurosciencep. 326
Neuroimaging of treatment effects in developmental neuropsychiatric disordersp. 344
Functional alleles, neuroimaging and intermediate phenotypes in the deconstruction of complex behavioral variation David Goldman, Beata Buzas and Ke Xup. 365
Progress and future directionsp. 383
Introduction to Section 5p. 385
Neuroimaging in developmental clinical neuroscience todayp. 387
Functional MRI educational resources and softwarep. 401
Neuroinformatics and neuroethics resourcesp. 403
Glossaryp. 407
Indexp. 437
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