Osteoimmunopathology

by Chiappelli, Francesco

• ISBN13: 9781441994943
• ISBN10: 1441994947
• Format: Hardcover
• Copyright: 2011-06-03
• Publisher: Springer Verlag

Summary

Osteoimmunology pertains to the study of the relationship between the bones, particularly the bone marrow, and the immune system. This monograph pursues the best available evidence, by means of research synthesis, for the characterization of the physiological relevance and pathological implications of the inter-connectedness between the skeletal and the immune system. Research will be discussed that highlights the associated role of the circulatory, nervous and endocrine systems, as well as proteomic and genomic pathways and signatures. Emphasis is given that domain of medicine that relates to the oral cavity, its diseases and their systemic sequelae. This monograph arises from observations that have suggested that the skeletal system and the immune system are intimately intertwined. Chronic inflammatory reactions subsequent to an excessive immune reaction can damage the bones, as in rheumatoid arthritis (RA), osteoporosis, patients seropositive for the human immunodeficiency virus (HIV)-1 and with signs and symptoms of the acquired immune deficiency syndrome (AIDS), and bone cancer. Bones #xE2;#xAC;#x1C; in particular the bone marrow #xE2;#xAC;#x1C; are one of the primary locations in which cells of the immune system mature. In brief, this monograph begins to answer a range of questions, such as, what is osteoimmunology all about?, does the immune system and its components affect bone development?, how do stress hormones impact upon the pathophysiology of bone-immune interactions?, can the scientific process of research synthesis, obtain the best available evidence for treatment of diseases involving the bone-immune entity (i.e., osteo immunopathologies) means of evidence-based clinical decision-making directed at the treatment of osteoimmune pathologies?

Table of Contents

Osteoimmunology: The Bone-Immune Crosstalk	p. 1
Historical Background	p. 1
Physiology	p. 3
The Bone Talks to the Immune System	p. 3
The Immune System Talks to the Bone	p. 16
The Osteoblastic Niche for Immunogenesis	p. 23
Implication for Stomatology	p. 25
Facial Osteology	p. 25
The Temporomandibular Joint	p. 32
Immuno-Biology of Facial Bony Structures	p. 35
Osteoimmunopathology	p. 39
Inflammatory Processes	p. 39
Osteoarthritis	p. 39
Osteoporosis in HIV- and HIV+ Persons	p. 40
Ankylosing Spondylitis	p. 50
Bone Tumors and Necroses	p. 55
Osteochondroma	p. 55
Bone Malignancies	p. 56
Osteonecrosis	p. 58
Stomatological Osteoimmunopathology	p. 59
Osteonecrosis of the Jaw	p. 59
Temporomandibular Disorders	p. 61
Fanconi Anemia	p. 66
Translational Evidence-Based Interventions in Osteoimmunology	p. 69
The State of the Art	p. 69
Research Synthesis	p. 69
Example of Existing Systematic Reviews in Osteoimmunology	p. 78
Clinical Decision-Making	p. 89
Directions for the Future	p. 91
Translational Evidence-Based Interventions: Toward a Novel Model	p. 91
Perfecting the Protocol for Getting the Best Available Evidence	p. 92
Implications for Stomatology	p. 99
Summary and Conclusion	p. 101
Glossary	p. 103
Notes	p. 113
References	p. 119
Index	p. 133
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