The Osteoporosis Primer

by Edited by Janet E. Henderson , David Goltzman

• ISBN13: 9780521644464
• ISBN10: 0521644461
• Format: Paperback
• Copyright: 2000-08-28
• Publisher: Cambridge University Press

Summary

Osteoporosis is one of the leading causes of morbidity and mortality amongst the elderly. The rationale for The Osteoporosis Primer is to provide an introductory text that relates the clinical presentation of osteoporosis to its molecular biochemical basis. The text has been organised into four sections that deal with the molecular/cellular components of bone, the development of peak bone mass, the pathophysiology of aging bone and, finally, how all of these relate to the prevention, diagnosis and treatment of osteoporosis. The international team of authors includes many leading clinicians and scientists who have provided the reader with a concise, yet comprehensive, synopsis of bone development and skeletal homeostasis. This will be an essential introduction for individuals working on osteoporosis including students and doctors considering a career related to metabolic bone disease, physicians in general practice, geriatricians, rheumatologists, and endocrinologists.

Table of Contents

List of contributors	viii
Preface	xiii
Part 1 Molecular and cellular environment of bone
Endochondral bone formation and development in the axial, and appendicular skeleton	3	(15)
A. Robin Poole
Sheila Laverty
Fackson Mwale
The role of osteoblasts	18	(18)
Jane E. Aubin
Osteoclasts: characteristics and regulation of formation and activity	36	(10)
Johan N. M. Heersche
Morris F. Manolson
Bone matrix proteins	46	(18)
Marc D. McKee
Jaro Sodek
Local regulators of bone turnover	64	(9)
Lawrence J. Fraher
Patricia H. Watson
The PTH/PTHrP system and calcium homeostasis	73	(15)
Geoffrey N. Hendy
Vitamin D metabolism	88	(14)
Marielle Gascon-Barre
Sodium-dependent phosphate transport in kidney, bone and intestine	102	(12)
Harriet S. Tenenhouse
Molecular genetic analysis of growth factor signaling in bone	114	(17)
Janet E. Henderson
David Goltzman
Part 2 Determinants of peak bone mass
Genetic determinants of osteoporosis	131	(16)
Millan S. Patel
Laurence A. Rubin
David E. C. Cole
Non-genetic determinants of peak bone mass	147	(23)
Velimir Matkovic
John D. Landoll
Bone mineral acquisition during childhood and adolescence: physical exercise as a preventative measure	170	(16)
Heather A. McKay
Karim M. Khan
Osteoporosis in children	186	(13)
Frank Rauch
Francis H. Glorieux
Part 3 Pathophysiology of the aging skeleton
Consequences of alterations in bone remodeling	199	(12)
Karen M. Prestwood
Lawrence G. Raisz
The role of parathyroid hormone and hyperparathyroidism in osteoporosis	211	(14)
Pierre D'Amour
Senile osteoporosis	225	(14)
Patrick M. Doran
Sundeep Khosla
Part 4 Clinical aspects of osteoporosis
Biochemical markers of bone turnover	239	(14)
David A. Hanley
Radiologic assessment of osteoporosis	253	(9)
Jacqueline C. Hodge
Bone mineral density measurements	262	(15)
Paul D. Miller
Carol Zapalowski
Hormone replacement therapy	277	(14)
Jonathan D. Adachi
Alexandra Papaioannou
Selective estrogen receptor modulators	291	(13)
Felicia Cosman
Robert Lindsay
Bisphosphonate therapy of osteoporosis	304	(14)
Frederick R. Singer
Payam Minoofar
The action of fluoride on bone	318	(13)
Marc D. Grynpas
Debbie Chachra
Hardy Limeback
PTH peptides as anabolic agents in bone	331	(16)
Anthony B. Hodsman
Vitamin D and vitamin D analogs as therapeutic agents	347	(17)
Richard Kremer
Index	364